TY - JOUR A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Ploska, Ute T1 - Rapid resorbable, glassy crystalline materials on the basis of calcium alkali orthophosphates KW - Keramik KW - Material kristallin, glasartig KW - Resorbtion KW - Knochenersatz PY - 1995 SN - 0142-9612 VL - 16 SP - 1241 EP - 1248 PB - Elsevier CY - Oxford AN - OPUS4-622 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Berger, Georg A1 - Gildenhaar, Renate T1 - Resorbierbarer Knochenersatz auf der Basis von Calciumphosphaten N2 - Neben Hydroxylapatit (HAp) findet verstärkt auch Tricalciumphosphat (TCP) Anwendung als Knochenersatzmaterial. In der Literatur finden sich widersprüchliche Angaben zur Löslichkeit von TCP. Bedingt durch unterschiedliche Darstellungsverfahren ergeben sich verschiedenartige Materialbeschaffenheiten, die sich erst nach der Implantation durch ein differenziertes Resorptions-verhalten dokumentieren (partikulärer Abbau, chemischer Lösungsprozeß). Zur Klärung derartiger Zusammenhänge in vitro wurden 2 Methoden zur Bestimmung des Lösungsverhaltens untersucht. Dafür wurden TCP-Proben aus verschiedenen Rohstoffen dargestellt, nach unterschiedlichen Temperaturregimen behandelt und/oder einer Nachbehandlung mit Phosphorsäure unterzogen. Diese Materialien wurden vor allem mittels Röntgenpulverdiffraktometrie und Rasterelektronenmikroskopie charakterisiert. In anschließenden Löslichkeitsuntersuchungen wurden die optimalen Versuchsparameter (Lösungsmittel, Konzentration, Verhältnis Lösungsmittelmenge zur Lösungsoberfläche usw.) sowie geeignete Meßgrößen (Masseverlust, Ionenkonzentration) ermittelt. Die In-vitro-Löslichkeit erwies sich bei sorgfältiger Auswahl der Versuchsbedingungen als sehr wirkungsvolle Charakterisierungsmöglichkeit, die auf synthesebedingte chemische und morphologische Unterschiede sehr empfindlich reagiert. Translated Abstract Resorbable bone substitution on the basis of calcium phosphates Besides hydroxyapatite (HAp), tricalcium phosphate is increasingly being used as bone substitution material. In literature there are contradictory claims of the TCP solubility. As a result of are contradictory claims of the TCP solubility. As a result of different manufacturing processes there are altered material properties, which are documented by different resorption behaviour especielly after implantation (particle separation, chemical solvatation). To clarify of such in vitro connections two methods for determining the solubility were investigated. Especially for this case, TCP samples prepared from different raw materials were synthesized. These samples were given different heat treatments and/or posttreatments with phosphoric acid. The materials were characterized above all by using X-ray powder diffraction method and scanning electron microscopy. Following investigations of the solubility lead to optimized testing parameters (solvent, concentration, ratio of solvent's quantity to sample surface, etc.) as well as qualified test parameters (lost of weight, ion concentration). When the test conditions were carefully selected, the in vitro solubillity was proved to be a very effective possibility of materials characterisation which is also very sensitive regarding chemical differences caused by synthesizing or morphological differences. KW - Knochenersatz KW - Calciumphosphat PY - 1995 DO - https://doi.org/10.1002/mawe.19950260711 SN - 0933-5137 SN - 1521-4052 VL - 26 IS - 7 SP - 379 EP - 385 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-623 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Knabe, C. A1 - Gildenhaar, Renate A1 - Berger, R. A1 - Ostapowicz, W. A1 - Fitzner, R. A1 - Radlanski, R. A1 - Gross, U. A1 - Siebert, G. T1 - In vitro examination of novel calcium phosphates using osteogenic cultures T2 - 5th World Biomaterials Congress CY - Toronto, Canada DA - 1996-05-29 KW - In-vitro Untersuchung KW - Kalzium-Phosphat KW - Zahnersatz KW - Knochen PY - 1996 VL - 1 SP - 890 CY - Toronto AN - OPUS4-672 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Ploska, Ute ED - Wilson, J. ED - Hench, L. T1 - Rapidly Resorbable Materials Based On A New Phase - CA2KNA(PO4)2 T2 - 8th International Symposium on Ceramics in Medicine CY - Ponte Vedra, FL, USA DA - 1995-11-01 KW - Material, resorbierbar KW - Knochensubstitut KW - Biomaterial PY - 1995 SN - 0-08-042677-8 VL - 8 SP - 453 EP - 456 PB - Elsevier Science CY - Oxford AN - OPUS4-603 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, Christine A1 - Adel-Khattab, Doaa A1 - Rezk, Mohamed A1 - Cheng, Jia A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Wilbig, Janka A1 - Günster, Jens A1 - Rack, Alexander A1 - Heiland, Max A1 - Knauf, Tom A1 - Stiller, Michael T1 - Osteogenic Effect of a Bioactive Calcium Alkali Phosphate Bone Substitute in Humans N2 - (1) Background: The desire to avoid autograft harvesting in implant dentistry has prompted an ever-increasing quest for bioceramic bone substitutes, which stimulate osteogenesis while resorbing in a timely fashion. Consequently, a highly bioactive silicon containing calcium alkali orthophosphate (Si-CAP) material was created, which previously was shown to induce greater bone cell maturation and bone neo-formation than β-tricalcium phosphate (β-TCP) in vivo as well as in vitro. Our study tested the hypothesis that the enhanced effect on bone cell function in vitro and in sheep in vivo would lead to more copious bone neoformation in patients following sinus floor augmentation (SFA) employing Si-CAP when compared to β-TCP. (2) Methods: The effects of Si-CAP on osteogenesis and Si-CAP resorbability were evaluated in biopsies harvested from 38 patients six months after SFA in comparison to β-TCP employing undecalcified histology, histomorphometry, and immunohistochemical analysis of osteogenic marker expression. (3) Results: Si-CAP as well as β-TCP supported matrix mineralization and bone formation. Apically furthest away from the original bone tissue, Si-CAP induced significantly higher bone formation, bone-bonding (bone-bioceramic contact), and granule resorption than β-TCP. This was in conjunction with a higher expression of osteogenic markers. (4) Conclusions: Si-CAP induced higher and more advanced bone formation and resorbability than β-TCP, while β-TCP’s remarkable osteoconductivity has been widely demonstrated. Hence, Si-CAP constitutes a well-suited bioactive graft choice for SFA in the clinical arena. KW - Silicon release KW - Bioceramics KW - Calcium alkali orthophosphate materials KW - Bioactive bone grafting material KW - Bioactivity KW - Osteogenesis KW - Bone regeneration KW - Sinus floor augmentation PY - 2023 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-591015 DO - https://doi.org/10.3390/bioengineering10121408 VL - 10 IS - 12 SP - 1 EP - 15 PB - MDPI AN - OPUS4-59101 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Lopez-Heredia, M.A. A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Linow, Ulf A1 - Wirth, Cynthia A1 - Günster, Jens A1 - Houshmand, A. A1 - Stiller, M. A1 - Knabe-Ducheyne, C. T1 - Effect of stressed and unstressed cell culture environments on the viability of MC3T3 cells with calcium phosphates T2 - ISACB-6 - International symposium on apatite and correlative biomaterials CY - Nantes, France DA - 2013-06-05 KW - Cell culture media KW - Fetal bovine serum KW - Stressed KW - Unstressed KW - Calcium alkaline orthophosphates PY - 2013 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-299387 DO - https://doi.org/10.4172/2090-5025.S1-002 SN - 2090-5017 SN - 2090-5025 N1 - Geburtsname von Wirth, Cynthia: Gomes, C. M. - Birth name of Wirth, Cynthia: Gomes, C. M. SP - 1 EP - 3(?) PB - Ashdin AN - OPUS4-29938 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Symietz, Christian A1 - Lehmann, Erhard A1 - Gildenhaar, Renate A1 - Hackbarth, Andreas A1 - Berger, Georg A1 - Krüger, Jörg T1 - Mechanical stability of Ti6Al4V implant material after femtosecond laser irradiation N2 - The surface of a titanium alloy (Ti6Al4V) implant material was covered with a bioactive calcium alkali phosphate ceramic with the aim to accelerate the healing and to form a stronger bond to living bone tissue. To fix the ceramic powder we used a femtosecond laser, which causes a thin surface melting of the metal. It is a requirement to prove that the laser irradiation would not reduce the lifetime of implants. Here we present the results of mechanical stability tests, determined by the rotating bending fatigue strength of sample rods. After describing the sample surfaces and their modifications caused by the laser treatment we give evidence for an unchanged mechanical stability. This applies not only to the ceramic fixation but also to a comparatively strong laser ablation. KW - Aluminium alloys KW - Bending strength KW - Bioceramics KW - Bone KW - Calcium compounds KW - Fatigue KW - Fatigue testing KW - High-speed optical techniques KW - Laser ablation KW - Melting KW - Orthopaedics KW - Prosthetics KW - Rods (structures) KW - Surface treatment KW - Titanium alloys KW - Vanadium alloys PY - 2012 DO - https://doi.org/10.1063/1.4737576 SN - 0021-8979 SN - 1089-7550 VL - 112 IS - 2 SP - 1 EP - 5 PB - American Institute of Physics CY - Melville, NY AN - OPUS4-26200 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Dreßler, Martin A1 - Dombrowski, Felix A1 - Simon, Ulla A1 - Börnstein, Julian A1 - Hodoroaba, Vasile-Dan A1 - Feigl, Michael A1 - Grunow, Sabrina A1 - Gildenhaar, Renate A1 - Neumann, Martin T1 - Influence of gelatine coatings on compressive strength of porous hydroxyapatite ceramics N2 - Porous ceramics prepared by the foam replication technique have a high porosity and low mechanical stability. It has been reported that coating such porous ceramics with gelatin allows for an improved compressive strength. Little details regarding the influence of important gelatin parameters such as concentration, temperature and drying conditions as well as bloom number which is a measure of the gel rigidity, on this toughening effect are available. This paper investigates the influence of these parameters on compressive strength of gelatin coated porous hydroxyapatite ceramics. It was found that concentration in the gelatin sols has a marked impact whereas sol temperature, bloom number and differing conditions during subsequent drying have only little influence on the compressive strength of the coated ceramics. KW - Films KW - Composites KW - Strength KW - Apatite KW - Biomedical application PY - 2011 DO - https://doi.org/10.1016/j.jeurceramsoc.2010.11.004 SN - 0955-2219 SN - 1873-619X VL - 31 IS - 4 SP - 523 EP - 529 PB - Elsevier Ltd. CY - Oxford AN - OPUS4-23216 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -