TY - JOUR A1 - Bernstein, A. A1 - Berger, Georg A1 - Brandt, J. A1 - Wenkel, R. A1 - Gildenhaar, Renate A1 - Zielezinski, T. A1 - Nöbel, D. T1 - Calciumtitanat (Ca4Ti3O10) - ein neues Material für Implantatbeschichtungen KW - Implantatbeschichtung KW - Calciumtitanat KW - Bioaktivität KW - Knochenkontakt KW - Biomaterial-bone-coating of an implant PY - 2004 SN - 1616-0177 SN - 0011-8656 VL - 5 IS - 4 SP - 242 EP - 248 PB - Verl. Neuer Merkur CY - München AN - OPUS4-6010 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, C. A1 - Howlett, C. R. A1 - Markovic, B. A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Zreiqat, H. T1 - The Functional Expression of Osteoblasts Grown on Rapid Resorbable Calcium Phosphates T2 - 15th International Symposium on Ceramics in Medicine ; 15th Annual meeting of the International Society for Ceramics in Medicine ; 15th Bioceramics CY - Sydney, NSW, Australia DA - 2002-12-04 KW - Guided bone regeneration KW - Calcium alkali orthophosphates KW - Osteoblasts KW - Cell differentiation PY - 2003 SN - 1013-9826 VL - 240-242 SP - 679 EP - 682 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-2115 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Bernstein, A. A1 - Hein, W. T1 - In-Vitro Surface Reactions of Plasma Sprayed Bioceramics T2 - International Symposium "Interface Biology of Implants" CY - Rostock, Germany DA - 2003-05-15 PY - 2003 SN - 1616-0177 SN - 0011-8656 VL - 4 IS - 2 SP - 106 PB - Verl. Neuer Merkur CY - München AN - OPUS4-2595 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bernstein, A. A1 - Gildenhaar, Renate A1 - Nöbel, D. A1 - Berger, Georg T1 - Biocompatibility screening of different calcium phosphate ceramics PY - 2003 SN - 1616-0177 SN - 0011-8656 VL - 4 IS - 2 SP - 89 PB - Verl. Neuer Merkur CY - München AN - OPUS4-2596 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gross, U. A1 - Müller-Mai, C. A1 - Knabe, C. A1 - Berger, Georg A1 - Ploska, Ute A1 - Gildenhaar, Renate ED - Vincenzini, P. T1 - Animal experiments with biomaterials for direct bone contact displaying higher or lower solubility in comparison to TCP and HA products T2 - 10th International Ceramics Congress ; 3rd Forum on New Materials ; 10th CIMTEC 2002 CY - Florence, Italy DA - 2002-07-14 PY - 2004 SP - 369 EP - 376 PB - Techna CY - Faenza AN - OPUS4-3500 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, Ch. A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Klar, F. A1 - Zreiqat, H. T1 - The modulation of osteogenesis in vitro by calcium titanium phosphate coatings N2 - Calcium phosphate coated titanium and titanium alloy are widely used as dental and orthopaedic implants. This study examines the effect of novel calcium titanium and calcium titanium zirconium phosphates suitable for plasma-spraying onto titanium substrata on the expression of bone-related genes and proteins by human bone-derived cells (HBDC) and compares this behavior to that on native titanium and hydroxyapatite-coated titanium. Test materials were an acid etched and sand-blasted titanium surface (Ti-DPS), a plasma-sprayed hydroxyapatite coating (HA), and five materials which were created from CaTi4(PO4)6 (CTP) and CaZr4(PO4)6 (CZP): sintered CaTi4(PO4)6 (CTP-S1), sintered 46CaO·23TiO2·31P2O5 (CTP-S2), sintered CaTiZr3(PO4)6, (CTZP-S1), sintered 46CaO·23ZrO2·31P2O5 (CTZP-S2) and sintered 55CaO·20TiO2·31P2O5 (CTP-S3). HBDC were grown on the substrata for 3, 7, 14 and 21 d, counted and probed for various mRNAs and proteins (type I collagen, osteocalcin, osteopontin, osteonectin, alkaline phosphatase and bone sialoprotein). All substrates significantly affected cellular growth and the temporal expression of an array of bone-related genes and proteins. At 14 and 21 d, cells on CTP-S3 displayed significantly enhanced expression of all osteogenic mRNAs. Surfaces of CTP-S1 and CTP-S3 had the most effect on osteoblastic differentiation inducing a greater expression of an array of osteogenic markers than recorded for cells grown on Ti-DPS and HA, suggesting that these novel materials may possess a higher potency to enhance osteogenesis. KW - Calcium phosphate coatings KW - Osteoblast KW - In vitro test KW - In situ hybridization KW - Osteogenesis PY - 2004 DO - https://doi.org/10.1016/j.biomaterials.2004.01.059 SN - 0142-9612 VL - 25 IS - 20 SP - 4911 EP - 4919 PB - Elsevier CY - Oxford AN - OPUS4-3501 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, C. A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Meyer, J. A1 - Howlett, C. A1 - Markovic, B. A1 - Zreiqat, H. T1 - Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro N2 - The use of biodegradable bone substitutes is advantageous for alveolar ridge augmentation because it avoids second-site surgery for autograft harvesting. This study examines the effect of novel, rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins by human bone-derived cells (HBDCs) and compares this behavior to that of tricalciumphosphate (TCP). Test materials were -TCP, two materials with a crystalline phase Ca2KNa(PO4)2 and with a small amorphous portion containing either magnesium potassium phosphate (material denominated GB14) or silica phosphate (material denominated GB9), and a calcium phosphate bone cement (material denominated Biocement D). HBDCs were grown on the substrata for 3, 7, 14, and 21 days, counted, and probed for various mRNAs and proteins (type I collagen, osteocalcin, osteopontin, osteonectin, alkaline phosphatase, and bone sialoprotein). All substrates supported continuous cellular growth for 21 days. In the presence of GB14 and Biocement D specimens cell proliferation was reduced and cell differentiation increased. At day 21, the greatest number of cells was found on GB9 expressing significantly higher levels of bone-related proteins than cells grown on all other surfaces. Because all novel materials facilitated the expression of the osteoblastic phenotype at least as much as TCP and the polystyrene control, these biomaterials can be regarded as excellent candidate bone substitute materials. GB9 induced the highest proliferation and cellular differentiation after 21 days of incubation, suggesting that this material may possess a higher potency for enhancing osteogenesis than TCP. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 69A: 145-154, 2004 KW - Calcium phosphate ceramics KW - Human bone-derived cells KW - Cell-biomaterial interactions KW - Calcium phosphate cements KW - In situ hybridization PY - 2004 DO - https://doi.org/10.1002/jbm.a.20131 SN - 1549-3296 SN - 1552-4965 VL - 69 IS - 1 SP - 145 EP - 154 PB - Wiley CY - Hoboken, NJ AN - OPUS4-3502 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, Ch. A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Howlett, C.R. A1 - Markovic, B. A1 - Zreiqat, H. T1 - The functional expression of human bone-derived cells grown on rapidly resorbable calcium phosphate ceramics N2 - The use of biodegradable bone substitutes is advantageous for alveolar ridge augmentation, since it avoids second-site surgery for autograft harvesting. This study examines the effect of novel, rapidly resorbable calcium phosphates on the expression of bone-related genes and proteins by human bone-derived cells (HBDC) and compares this behavior to that of tricalciumphosphate (TCP). Test materials were a-TCP, and four materials which were created from ß-Rhenanite and its derivatives: R1-ß-Rhenanite (CaNaPO4); R1/M2 composed of CaNaPO4 and MgNaPO4; R1+SiO2 composed of CaNaPO4 and 9% SiO2 (wt%); and R17-Ca2KNa(PO4)2. HBDC were grown on the substrata for 3, 5, 7, 14 and 21 days, counted and probed for various mRNAs and proteins (Type I collagen, osteocalcin, osteopontin, osteonectin, alkaline phosphatase and bone sialoprotein). All substrata supported continuous cellular growth for 21 days. At day 21, surfaces of R1+SiO2 and R17 had the highest number of HBDC. At 14 and 21 days, cells on R1 and on R1+SiO2 displayed significantly enhanced expression of all osteogenic proteins. Since all novel calcium phosphates supported cellular proliferation together with expression of bone-related proteins at least as much as TCP, these ceramics can be regarded as potential bone substitutes. R1 and R1+SiO2 had the most effect on osteoblastic differentiation, thus suggesting that these materials may possess a higher potency to enhance osteogenesis than TCP. KW - Calcium phosphate ceramics KW - Human bone-derived cells KW - Cell-biomaterial interactions KW - Bone substitutes KW - In situ hybridization PY - 2004 DO - https://doi.org/10.1016/S0142-9612(03)00525-8 SN - 0142-9612 VL - 25 IS - 2 SP - 335 EP - 344 PB - Elsevier CY - Oxford AN - OPUS4-2957 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Lehmann, Erhard A1 - Stiller, M. A1 - Koch, C. A1 - Ducheyne, P. A1 - Rack, A. A1 - Seligmann, H. A1 - Jonscher, S. A1 - Knabe, C. T1 - A comparative study of the biodegradability of calcium-alkali-orthophosphate ceramics in vitro and in vivo KW - Calcium-alkali-orthophosphate KW - Solubility KW - Biodegradability PY - 2007 SN - 1013-9826 VL - 330-332 SP - 63 EP - 66 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-14528 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bernstein, A. A1 - Nöbel, D. A1 - Mayr, H.O. A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Ploska, Ute A1 - Brandt, J. T1 - Influence of Calcium Zirconium Phosphate Containing Coatings on Mineralization of Bone KW - Ceramics KW - Coating KW - Biomaterial KW - Bone KW - Biocompatibility KW - Surface reaction PY - 2008 SN - 1013-9826 VL - 361-363 SP - 641 EP - 644 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-15900 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Lehmann, Erhard A1 - Knabe, C. T1 - Development of Alkali Containing Calcium Phosphate Cements KW - Calcium phosphate cement KW - Calcium potassium sodium phosphate KW - Potassium containing apatite KW - Bone substitute materials PY - 2008 SN - 1013-9826 VL - 361-363 SP - 331 EP - 334 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-15902 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gildenhaar, Renate T1 - Development of alkali containing calcium phosphate cements T2 - 20th Int. Symposium of Ceramics in Medicine (Bioceramics 20) CY - Nantes, France DA - 2007-10-24 PY - 2007 AN - OPUS4-15862 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, C. A1 - Houshmand, A. A1 - Berger, Georg A1 - Ducheyne, P. A1 - Gildenhaar, Renate A1 - Kranz, I. A1 - Stiller, M. T1 - Effect of rapidly resorbable bone substitute materials on the temporal expression of the osteoblastic phenotype in vitro N2 - Ideally, bioactive ceramics for use in alveolar ridge augmentation should possess the ability to activate bone formation and, thus, cause the differentiation of osteoprogenitor cells into osteoblasts at their surfaces. Therefore, in order to evaluate the osteogenic potential of novel bone substitute materials, it is important to examine their effect on osteoblastic differentiation. This study examines the effect of rapidly resorbable calcium-alkali-orthophosphates on osteoblastic phenotype expression and compares this behavior to that of β-tricalcium phosphate (TCP) and bioactive glass 45S5. Test materials were three materials (denominated GB14, GB9, GB9/25) with a crystalline phase Ca2KNa(PO4)2 and with a small amorphous portion containing either magnesium potassium phosphate (GB14) or silica phosphate (GB9 and GB9/25, which also contains Ca2P2O7); and a material with a novel crystalline phase Ca10[K/Na](PO4)7 (material denominated 352i). SaOS-2 human bone cells were grown on the substrata for 3, 7, 14, and 21 days, counted, and probed for an array of osteogenic markers. GB9 had the greatest stimulatory effect on osteoblastic proliferation and differentiation, suggesting that this material possesses the highest potency to enhance osteogenesis. GB14 and 352i supported osteoblast differentiation to the same or a higher degree than TCP, whereas, similar to bioactive glass 45S5, GB9/25 displayed a greater stimulatory effect on osteoblastic phenotype expression, indicating that GB9/25 is also an excellent material for promoting osteogenesis. KW - Bone substitute materials KW - Calcium-alkali-orthophosphate ceramics KW - SaOS-2 cells KW - Osteoblast differentiation KW - Bioactive glass PY - 2008 DO - https://doi.org/10.1002/jbm.a.31383 SN - 1549-3296 SN - 1552-4965 VL - 84A IS - 4 SP - 856 EP - 868 PB - Wiley CY - Hoboken, NJ AN - OPUS4-16658 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gildenhaar, Renate T1 - Calcium alkaline phosphate scaffolds for bone regeneration 3D-fabricated by additive manufacturing T2 - 23rd Symp. and Annual Meeting of Intern. Soc. for Ceramics in Medicine (ISCM) CY - Istanbul, Turkey DA - 2011-11-04 PY - 2011 N1 - Geburtsname von Wirth, Cynthia: Gomes, C. M. - Birth name of Wirth, Cynthia: Gomes, C. M. AN - OPUS4-24863 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gildenhaar, Renate A1 - Knabe, C. A1 - Wirth, Cynthia A1 - Linow, Ulf A1 - Houshmand, A. A1 - Berger, Georg T1 - Calcium alkaline phosphate scaffolds for bone regeneration 3D-fabricated by additive manufacturing N2 - Calcium alkaline phosphate granulates can be used for substitution of several bone defects but for the reconstruction of large skeletal parts in the maxillofacial and orthopaedic fields fitted scaffolds are preferable. Within the additive manufacturing methods, the 3D printing process offers exciting opportunities to generate defined porous scaffolds. We used a R1 printer from ProMetal Company, USA, for producing scaffolds directly from a ceramic powder. For this direct free form fabrication technology the powder has to possess a lot of specific properties both for the generation of a stable green body and also for the subsequent sintering preparation. For this printing process we prepared different granules in a fluidized bed process containing Ca2KNa(PO4)2 as main crystalline phase. Granules were characterized by different methods and several sieve fractions were used for preparing disc like and cylindrical parts. The suitability of granules for this printing process was determined by porosity and strength of produced bodies. Next to granules' performance both of these properties can be directly influenced by 3D printing process parameters. With knowledge of suitable process parameters scaffolds with different porosity in a respective desired design can be created. In this study, cylindrical scaffolds with graded porosity were produced for bone regeneration of segmental defects in maxillofacial surgery and dental implantology by tissue engineering. KW - 3D printing KW - Calcium alkaline phosphates KW - Ceramic scaffolds KW - Oral surgery PY - 2012 DO - https://doi.org/10.4028/www.scientific.net/KEM.493-494.849 SN - 1013-9826 N1 - Geburtsname von Wirth, Cynthia: Gomes, C. M. - Birth name of Wirth, Cynthia: Gomes, C. M. VL - 493-494 SP - 849 EP - 854 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-24989 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Quillard, S. A1 - Mellier, C. A1 - Gildenhaar, Renate A1 - Hervelin, J. A1 - Deniard, P. A1 - Berger, Georg A1 - Bouler, J.-M. T1 - Raman and infrared studies of substituted ß-TCP N2 - Several substituted β-tricalcium phosphates have been prepared with different cations (monovalent, divalent and trivalent) and at various levels of substitution. Structural investigations have proved that fewer than ~10% wt substitution, the substituted compounds are isostructural to β-TCP, leading to solid solutions. These samples have been characterized by infrared and Raman spectroscopies. The vibrational spectra show mainly the bands related to the vibrations of PO43- tetrahedrons present in the structure. As Raman scattering and infrared absorption are local probes, the bands are sensitive to the local environment of the distinct tetrahedrons, related to the site of substitution and to the nature of the cations. KW - Tricalcium phosphates KW - Ionic substitution KW - Vibrational spectroscopies PY - 2012 DO - https://doi.org/10.4028/www.scientific.net/KEM.493-494.225 SN - 1013-9826 VL - 493-494 SP - 225 EP - 230 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-24954 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, C. A1 - Howlett, C. A1 - Markovic, B. A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Zreiqat, H. T1 - The functional expression of human osteoblasts grown on resorbable calcium phosphates N2 - The use of biodegradable bone substitutes is advantageous for alveolar ridge augmentation, since it avoids second-site surgery for autograft harvesting. This study examines the effect of novel, rapidly resorbable calcium phosphates on the expression of bone-related genes and proteins by human bone derived cells (HBDC) and compares this behavior to that of tricalciumphosphate (TCP). Test materials were -TCP, a newly synthesized chemical Ca2KNa(PO4)2 (material denominated R17), two glassy crystalline materials with a crystalline phase Ca2KNa(PO4)2 and in addition a small amorphous portion containing either magnesium potassium phosphate (material denominated GB14) or silica phosphate (material denominated GB9). HBDC was grown on the substrates for 3, 5, 7, 14 and 21 days, counted and probed for various mRNAs and proteins (collagen type I, osteocalcin, osteopontin, osteonectin, alkaline phosphatase and bone sialoprotein). All substrates supported continuous cellular growth for 21 days. At day 21, R17, GB9, TCP and GB14. T2 - 15th International Symposium on Ceramics in Medicine CY - Sydney, NSW, Australia DA - 2002-12-04 PY - 2002 DO - https://doi.org/10.4028/www.scientific.net/KEM.240-242.679 SN - 1013-9826 VL - 240-242 SP - 679 EP - 682 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-1891 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Knabe, C. A1 - Howlett, C. A1 - Markovic, B. A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Reif, D. A1 - Zreiqat, H. T1 - The functional expression of human bone derived cells grown on resorbable bioactive glass ceramics T2 - 28th Annual Meeting & Exposition of the Society for Biomaterials CY - Tampa, FL, USA DA - 2002-04-23 PY - 2002 SP - 706 PB - Society for Biomaterials AN - OPUS4-1892 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gross, U. A1 - Müller-Mai, C. A1 - Knabe, C. A1 - Berger, Georg A1 - Ploska, Ute A1 - Gildenhaar, Renate ED - Vincenzini, P. T1 - Animal experiments with biomaterials for direct bone contact which possess in comparison to TCP and HA products higher or lower solubility T2 - 10th International Ceramics Congress ; 3rd Forum on New Materials ; 10th CIMTEC 2002 CY - Florence, Italy DA - 2002-07-14 PY - 2003 PB - Techna CY - Faenza AN - OPUS4-1894 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Knabe, C. A1 - Howlett, C.R. A1 - Markovic, B. A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Zreiqat, H. T1 - Beeinflussung der Gen- und Proteinexpression von Osteoblasten durch bioaktive resorbierbare Glaskeramiken T2 - Bericht der 2. gemeinsamen Jahrestagung der Deutschen Gesellschaft für Implantologie im Zahn-, Mund- und Kieferbereich, der Österreichischen Gesellschaft für orale Chirurgie und Implantologie sowie der Schweizerischen Gesellschaft für orale Implantologie CY - München, Deutschland DA - 2002-12-05 PY - 2002 AN - OPUS4-1898 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Knabe, C. A1 - Howlett, C. A1 - Markovic, B. A1 - Klar, F. A1 - Zreiqat, H. T1 - The Effect of Different Dental Titanium and Calcium Phosphate Implant Surfaces on the Expression of Bone-Related Genes and Proteins in vitro T2 - 6th World Biomaterials Congress CY - Kamuela, Big Island, HI, USA DA - 2000-05-15 KW - Dental Implant Surfaces PY - 2000 VL - 1 SP - 238 PB - Society for Biomaterials CY - Minneapolis, Minn. AN - OPUS4-869 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Knabe, C. A1 - Howlett, C. A1 - Markovic, B. A1 - Reif, D. A1 - Zreiqat, H. T1 - The Functional Expression of Human Bone Derived Cells Grown on Rapidly Resorbable Calcium Phosphate Ceramics T2 - 6th World Biomaterials Congress CY - Kamuela, Big Island, HI, USA DA - 2000-05-15 KW - Calcium Phosphate Ceramics PY - 2000 SP - 970 PB - Society for Biomaterials CY - Minneapolis, Minn. AN - OPUS4-870 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Ploska, Ute T1 - Rapid resorbable, glassy crystalline materials on the basis of calcium alkali orthophosphates KW - Keramik KW - Material kristallin, glasartig KW - Resorbtion KW - Knochenersatz PY - 1995 SN - 0142-9612 VL - 16 SP - 1241 EP - 1248 PB - Elsevier CY - Oxford AN - OPUS4-622 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Berger, Georg A1 - Gildenhaar, Renate T1 - Resorbierbarer Knochenersatz auf der Basis von Calciumphosphaten N2 - Neben Hydroxylapatit (HAp) findet verstärkt auch Tricalciumphosphat (TCP) Anwendung als Knochenersatzmaterial. In der Literatur finden sich widersprüchliche Angaben zur Löslichkeit von TCP. Bedingt durch unterschiedliche Darstellungsverfahren ergeben sich verschiedenartige Materialbeschaffenheiten, die sich erst nach der Implantation durch ein differenziertes Resorptions-verhalten dokumentieren (partikulärer Abbau, chemischer Lösungsprozeß). Zur Klärung derartiger Zusammenhänge in vitro wurden 2 Methoden zur Bestimmung des Lösungsverhaltens untersucht. Dafür wurden TCP-Proben aus verschiedenen Rohstoffen dargestellt, nach unterschiedlichen Temperaturregimen behandelt und/oder einer Nachbehandlung mit Phosphorsäure unterzogen. Diese Materialien wurden vor allem mittels Röntgenpulverdiffraktometrie und Rasterelektronenmikroskopie charakterisiert. In anschließenden Löslichkeitsuntersuchungen wurden die optimalen Versuchsparameter (Lösungsmittel, Konzentration, Verhältnis Lösungsmittelmenge zur Lösungsoberfläche usw.) sowie geeignete Meßgrößen (Masseverlust, Ionenkonzentration) ermittelt. Die In-vitro-Löslichkeit erwies sich bei sorgfältiger Auswahl der Versuchsbedingungen als sehr wirkungsvolle Charakterisierungsmöglichkeit, die auf synthesebedingte chemische und morphologische Unterschiede sehr empfindlich reagiert. Translated Abstract Resorbable bone substitution on the basis of calcium phosphates Besides hydroxyapatite (HAp), tricalcium phosphate is increasingly being used as bone substitution material. In literature there are contradictory claims of the TCP solubility. As a result of are contradictory claims of the TCP solubility. As a result of different manufacturing processes there are altered material properties, which are documented by different resorption behaviour especielly after implantation (particle separation, chemical solvatation). To clarify of such in vitro connections two methods for determining the solubility were investigated. Especially for this case, TCP samples prepared from different raw materials were synthesized. These samples were given different heat treatments and/or posttreatments with phosphoric acid. The materials were characterized above all by using X-ray powder diffraction method and scanning electron microscopy. Following investigations of the solubility lead to optimized testing parameters (solvent, concentration, ratio of solvent's quantity to sample surface, etc.) as well as qualified test parameters (lost of weight, ion concentration). When the test conditions were carefully selected, the in vitro solubillity was proved to be a very effective possibility of materials characterisation which is also very sensitive regarding chemical differences caused by synthesizing or morphological differences. KW - Knochenersatz KW - Calciumphosphat PY - 1995 DO - https://doi.org/10.1002/mawe.19950260711 SN - 0933-5137 SN - 1521-4052 VL - 26 IS - 7 SP - 379 EP - 385 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-623 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -