TY - JOUR A1 - Kubeil, M. A1 - Zarschler, K. A1 - Pietzsch, J. A1 - Kraus, Werner A1 - Comba, P. A1 - Stephan, H. T1 - Copper(II) cyclam complexes with N-propionic acid pendant arms JF - European journal of inorganic chemistry N2 - Four cyclam (1,4,8,11-tetraazacyclotetradecane) ligands with different numbers of N-substituted propionic acid groups lead to pentacoordinate copper(II) complexes that adopt trans-I configurations (4+1 geometry), that is, the complexes have a dx2-y2 ground state with significant rhombic distortion. From the structural data (X-ray diffraction analysis and electron paramagnetic resonance, UV/Vis and IR spectroscopy), as the number of secondary amine groups of the macrocyclic ring substituted with propionic acid groups increases, the distortion from square pyramidal to trigonal bipyramidal increases, and this is expected to lead to relatively low complex stabilities. This is confirmed by in vitro studies with superoxide dismutase (SOD) and human serum challenge experiments as well as by biodistribution data with the 64Cu-labelled complexes. The 64Cu-labelled complexes with cyclam monopropionic and dipropionic acid show high in vitro and in vivo stabilities, and the latter provides a comparable biodistribution profile to that of 64Cu–TETA (TETA = 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid). KW - Copper KW - Chelates KW - Macrocyclic ligands KW - Radiopharmaceuticals KW - Diagnostic and therapy KW - Copper complexes PY - 2015 DO - https://doi.org/10.1002/ejic.201500510 SN - 1434-1948 SN - 1099-0682 IS - 24 SP - 4013 EP - 4023 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-33993 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -