TY - CONF A1 - Apel, Andreas A1 - Wille, Frank A1 - Moutarde, M. A1 - Sert, G. A1 - Caillard-Lizot, M.-T. A1 - Eckert, B. A1 - Konnai, A. A1 - Pstrak, D. A1 - Harvey, J. A1 - Desnoyers, B. A1 - Purcell, P. A1 - Fiaccabrino, V. T1 - Stowage during transport: a proposal for harmonization T2 - Tagungsband PATRAM 2016 N2 - For stowage and retention during transport, the International Atomic EnergyAgency (IAEA) Transport regulations (SSR-6) only require that the package shall be securely stowed. Additional information is given in the IAEA guidance material (SSG-26), that includes specific load factors that should be considered in the safety demonstrations. Nevertheless, applicants commonly use other load factors to justify the design of the packaging attachment points. In particular, acceleration values vary between different countries and this may lead to difficulties during the validation of foreign approval certificates. Discussions with applicants identified that the load factors presented in the IAEA guidance material are not necessarily relevant for the different transport modes. For some modes, the load factors are representative of situations occurring in routine conditions of transport. For other modes, the load factors are more representative of situations occurring in normal or accident conditions of transport. Furthermore, the origins of the specified values are not clear. In this context, some IAEA TRANSSC members decided to review the stowage guidance. An international working group was constituted in 2013, including representatives of competent authorities, technical support organizations, and transport stakeholders. Several topics were discussed and many questions were raised during the two year review. For example, some discussions focused on Paper No.1031 2 the conditions which have to be considered for stowage design, both as relevant to the load factors used for strength and fatigue analysis, as well as the criteria which have to be considered for the package attachment points. In addition, related questions on operational aspects were also discussed. Overall, the working group concluded that new guidance material was warranted as input into SSG-26. As a result of those discussions, the international working group produced new guidance material for stowage in transport, addressing each of these topics. The proposal to modify the IAEA guidance material (SSG-26, Appendix IV), presented by France to the TRANSSC in the 2015 initiated Review cycle of the Regulations, was unanimously accepted and will be implemented in the next edition of the guidance material. T2 - PATRAM 2016 CY - Kobe, Japan DA - 18.09.2016 KW - Packages for radioactive material KW - IAEA regulations (SSR-6, SSG-26) KW - Tie-down and stowage KW - Load cases for transport KW - Design of the packaging attachment points PY - 2016 SP - Paper 1031, 1 EP - 8 AN - OPUS4-38644 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Martynenko, Irina A1 - Litvin, A.P. A1 - Purcell-Milton, F. A1 - Baranov, A. V. A1 - Fedorov, A.V. A1 - GunĀ“ko, Y.K. T1 - Application of semiconductor quantum dots in bioimaging and biosensing JF - Journal of Materials Chemistry B N2 - In this review we present new concepts and recent progress in the application of semiconductur quantum dots (QD) as labels in two important areas of biology, bioimaging and biosensing. We analyze the biologically relevant properties of QDs focusing on the following topics: QD surface treatment and stability labeling of cellular structures and receptors with QDs, incorporation of QDs in living cells, cytotoxicity of QDs and influence of the biolocical environment on the biological and optical properties of QDs. Initially, we consider utilization of QDs as agants in high-resolution bioimaging techniques that can provide information at the molecular levels. The deverse range of modern live-cell QD-based imaging techniques with resolution far beyond the diffraction limit of light is examined. In each technique, we discuss the pros and cons of QD use and deliberate how QDs can be further engineered to facilitate their application in the respective imaging techniques and to produce significant improvements in resolution. Then we review QD-based point-of-care bioassays, bioprobes, and biosensors designed in different formats ranging from analytic biochemistry assays and ELISA, to novel point-of-care smartphone integrated QD-based biotests. Here, a wide range of QD-based fluorescence bioassays with optical transduction, electrochemiluminescence and photoelectrochemical assays are discussedc. Finally, this review provides an analysis of the prospects of application of QDs in selected important Areas of biology. KW - Fluorescence KW - Semiconductor quantum dot KW - Imaging KW - Quantification KW - Nanoparticle KW - NIR KW - IR KW - Quantum yield KW - Method KW - Microscopy KW - Assay KW - Bioconjugate PY - 2017 DO - https://doi.org/10.1039/c7tb01425b VL - 5 IS - 33 SP - 6701 EP - 6727 PB - Royal Society of Chemistry AN - OPUS4-43027 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -