TY - CONF A1 - Elert, Anna Maria A1 - Meyer, Lena A1 - Brunner, Nanine A1 - Melzer, Micheal A1 - Koch, Claudia T1 - Advancing Digital Quality Infrastructure: Transforming Laboratory Processes for Enhanced Efficiency and Reliability N2 - The digital Quality Infrastructure (QI) holds significant potential for ensuring and enhancing the accuracy, reliability, and efficiency of laboratory processes. Establishing digital QI tools and processes and the integration into the larger digital QI ecosystem however comes with many technical and organizational challenges at the laboratory but also larger system level. This paper presents solutions of a digital QI tool set that are being developed within the German initiative QI-Digital, our own experiences in the implementation of Digital Calibration Certificates (DCCs) as eAttestation in our laboratory, as well as the structured process we have been establishing to engage with the laboratory community to support adoption of the digital QI. T2 - 2025 IMEKO TC-6 International Conference of Metrology and Digital Transformation - M4DConf CY - Benevento, Italy DA - 03.09.2025 KW - Digital Calibration Certificate KW - Digitalization KW - Laboratories KW - Quality Inflastructure PY - 2025 VL - 2025 SP - 1 EP - 6 AN - OPUS4-64283 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Meyer, Lena A1 - Elert, Anna Maria A1 - Koch, Claudia T1 - A digital Quality Infrastructure for testing and calibration laboratories: from theory to practice N2 - The digital Quality Infrastructure (QI) offers significant potential to enhance the technical excellence and efficiency of laboratory operations. By leveraging tools and processes of a digital QI laboratories, their customers, authorities and other stakeholders can enhance efficiency foster trust and generate added value. This paper introduces the digital QI toolset and ecosystem as developed in the German initiative QI Digital, and explores concrete Scenarios for their implementation in laboratories Successful rollout not only requires technical development but also intense stakeholder engagement . Consequently, this paper shares insights and outcomes from a structured stakeholder dialogue with the laboratory community, and outlines the establishment of the digital LabHub' as a pivotal step to drive digital transformation and facilitate the widespread Adoption of digital QI within laboratories and their broader ecosystem. T2 - 2025 IMEKO Joint Conference TC8 -TC11 - TC24 CY - Turin, Italy DA - 14.09.2025 KW - Quality Infrastructure KW - Digitalization KW - Laboratories PY - 2025 SP - 1 EP - 6 AN - OPUS4-64282 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Teutenberg, Thorsten A1 - Blöth, Anton A1 - Bolling, Janina A1 - Kuch, Susanne A1 - Meyer, Lena A1 - Rösch, Richard T1 - Auf dem Weg in die digitale Transformation N2 - Die Digitalisierung in der Laborbranche stellt eine komplexe Herausforderung dar – nicht zuletzt aufgrund zahlreicher Einzelprojekte und vieler proprietärer Insellösungen. Um eine konsequente und wirkungsvolle Labordigitalisierung und Prozessautomatisierung zu erreichen, braucht es eine übergreifende Sichtbarkeit und Vernetzung bestehender Initiativen. Diese Notwendigkeit haben verschiedene Akteure der Laborbranche erkannt und, angestoßen durch die Initiative QI-Digital, den Digital LabHub ins Leben gerufen. Ziel ist es, eine Plattform für Wissensaustausch und -transfer, gegenseitige Unterstützung und praxisnahe Umsetzung zu schaffen – offen für Labore aller Branchen und Anwendungsfelder. Der Digital LabHub soll gezielte Hilfestellung beim Einstieg in die Digitalisierung bieten, Labore zukunftssicher aufstellen und dabei helfen, regulatorische Anforderungen zu erfüllen. KW - Digitale Transformation KW - Digitalisierung KW - Kalibrierlabor KW - Prüflabor KW - QI-Digital KW - Qualitätsinfrastruktur PY - 2025 UR - https://analyticalscience.wiley.com/content/article-do/auf-dem-weg-die-digitale-transformation SP - 1 EP - 3 PB - Wiley Analytical Science CY - Weinheim AN - OPUS4-64482 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Blöth, Anton A1 - Bolling, Janina A1 - Teutenberg, Thorsten A1 - Meyer, Lena T1 - Digital LabHub - Gemeinsam die digitale Transformation der Laborbranche vorantreiben N2 - Als zentrale Drehscheibe für Information und Vernetzung begleitet der Digital LabHub Labore auf dem Weg der digitalen Transformation: praxisnah, kollaborativ und zukunftsorientiert. Die Drehscheibe bietet Orientierung, fördert den Austausch und macht bestehende Initiativen sichtbar. Der Digital LabHub bringt Akteure aus der und um die Laborbranche zusammen, um Wissen zu teilen, Synergien zu schaffen und Innovationen voranzutreiben. T2 - QI-Digital Forum 2025 CY - Berlin, Germany DA - 08.10.2025 KW - Digitale Transformation KW - Digitalisierung KW - Kalibrierlabor KW - Prüflabor KW - QI-Digital KW - Qualitätsinfrastruktur PY - 2025 AN - OPUS4-64481 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Fliehe, Marc A1 - Steinke, Ingo A1 - Koch, Claudia A1 - Elert, Anna Maria A1 - Meyer, Lena T1 - Konformität digital nachweisen: Maschinenlesbare Zertifikate für mehr Vertrauen und Effizienz N2 - Die fortschreitende Digitalisierung und die Komplexität globaler Lieferketten erfordern ein Umdenken in der Qualitätsinfrastruktur (QI). Papierbasierte Prozesse werden den Anforderungen der digitalen Wirtschaft nicht mehr gerecht. Um wettbewerbsfähig zu bleiben und Handelshemmnisse abzubauen, müssen diese Strukturen modernisiert werden. Digitale, maschinenlesbare Zertifikate ermöglichen eine Neugestaltung der Qualitätssicherung entlang globaler Wertschöpfungsketten. Sie bieten Verbraucher*innen, Wirtschaft und Behörden erhebliche Vorteile, erleichtern die Automatisierung von Konformitätsprüfungen und unterstützen die Einhaltung komplexer regulatorischer Anforderungen. KW - Digitale Zertifikate KW - Maschinenlesbare Zertifikate KW - Digitale Transformation KW - Digitalisierung KW - Qualitätsinfrastruktur KW - Konformitätsbewertung PY - 2024 SP - 1 EP - 16 CY - Berlin AN - OPUS4-62043 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Koch, Claudia A1 - Elert, Anna Maria A1 - Meyer, Lena T1 - Vertrauen stärken und Innovation ermöglichen: Eine digitale Qualitätsinfrastruktur für ein modernes Made-in-Germany N2 - Produktion und Handel in immer komplexeren Wertschöpfungsnetzwerken, die fortschreitende digitale und grüne Transformation sowie technologische Innovationen sind in hohem Maße auf die verlässliche Sicherung und den effizienten Nachweis der Qualität, Sicherheit und Nachhaltigkeit von Waren, Dienstleistungen und Prozessen angewiesen. Unverzichtbar dafür ist eine moderne und leistungsfähige Qualitätsinfrastruktur (QI). Der Artikel stellt die Initiative QI-Digital, ihre Ziele und Aktivitäten für die digitale Transformation der QI vor. KW - Qualitätsinfrastruktur KW - Qualitätssicherung KW - Digitalisierung KW - digitale Transformation KW - Smart Standard KW - Digitales Zertifikat KW - DPP PY - 2024 UR - https://www.dgq.de/fachbeitraege/vertrauen-staerken-und-innovation-ermoeglichen-eine-digitale-qualitaetsinfrastruktur-fuer-ein-modernes-made-in-germany/ SP - 1 EP - 5 AN - OPUS4-60345 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Meyer, Lena T1 - From status quo to first perspectives of laboratories in a digital quality infrastructure N2 - The future of an efficient quality infrastructure (QI) will depend not only on suitable digital tools but also on well-equipped laboratories. An international study conducted by BAM reveals significant variation in digitalization among Germany's conformity assessment bodies (https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/59765). While laboratories see digitalization as an opportunity, most are still in the early stages of digital maturity, facing challenges such as: complexity, costs, staff, and lack of uniform interfaces and standards. To better understand expectations, needs, and experiences, QI-Digital held workshops with over 100 participants and first results are available in this publication. This ongoing dialogue is vital to ensuring that digital QI evolves in a way that is both practical and aligned with the dynamic needs of the industry. As laboratories navigate the diverse challenges of innovation, digital transformation becomes not just an option, but a powerful opportunity to stay ahead in a market that thrives on new, innovative, and digitally driven competitors. T2 - Materials Science and Engineering Congress 2024 CY - Darmstadt, Germany DA - 24.09.2024 KW - Digital Transformation KW - Quality Infrastructure KW - Conformity Assessment KW - Accreditation KW - Quality Assurance PY - 2024 AN - OPUS4-61127 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Srivastava, Priyanka A1 - Tavernaro, Isabella A1 - Scholtz, Lena A1 - Genger, C. A1 - Welker, P. A1 - Schreiber, Frank A1 - Meyer, Klas A1 - Resch-Genger, Ute T1 - Dual color pH probes made from silica and polystyrene nanoparticles and their performance in cell studies N2 - Ratiometric green–red fluorescent nanosensors for fluorometrically monitoring pH in the acidic range were designed from 80 nm-sized polystyrene (PS) and silica (SiO2) nanoparticles (NPs), red emissive reference dyes, and a green emissive naphthalimide pH probe, analytically and spectroscopically characterized, and compared regarding their sensing performance in aqueous dispersion and in cellular uptake studies. Preparation of these optical probes, which are excitable by 405 nm laser or LED light sources, involved the encapsulation of the pH-inert red-fuorescent dye Nile Red (NR) in the core of self-made carboxylated PSNPs by a simple swelling procedure and the fabrication of rhodamine B (RhB)-stained SiO2-NPs from a silane derivative of pH-insensitive RhB. Subsequently, the custom-made naphthalimide pH probe, that utilizes a protonation-controlled photoinduced electron transfer process, was covalently attached to the carboxylic acid groups at the surface of both types of NPs. Fluorescence microscopy studies with the molecular and nanoscale optical probes and A549 lung cancer cells confirmed the cellular uptake of all probes and their penetration into acidic cell compartments, i.e., the lysosomes, indicated by the switching ON of the green naphthalimide fluorescence. This underlines their suitability for intracellular pH sensing, with the SiO2-based nanosensor revealing the best performance regarding uptake speed and stability. KW - Sensors KW - Silica and polystyrene nanoparticles KW - pH probe KW - Fluorescence spectroscopy KW - Cell studies KW - Dye KW - Particle synthesis PY - 2023 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-569198 DO - https://doi.org/10.1038/s41598-023-28203-0 SN - 2045-2322 VL - 13 IS - 1 SP - 1321 EP - 1336 PB - Nature CY - London AN - OPUS4-56919 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Ginés-Palomares, Juan Carlos A1 - Fateri, Miranda A1 - Kalhöfer, Eckhard A1 - Schubert, Tim A1 - Meyer, Lena A1 - Kolsch, Nico A1 - Brandic Lipinska, Monica A1 - Davenport, Robert A1 - Imhof, Barbara A1 - Waclavicek, René A1 - Sperl, Matthias A1 - Makaya, Advenit A1 - Günster, Jens T1 - Laser melting manufacturing of large elements of lunar regolith simulant for paving on the Moon N2 - The next steps for the expansion of the human presence in the solar system will be taken on the Moon. However, due to the low lunar gravity, the suspended dust generated when lunar rovers move across the lunar soil is a significant risk for lunar missions as it can affect the systems of the exploration vehicles. One solution to mitigate this problem is the construction of roads and landing pads on the Moon. In addition, to increase the sustainability of future lunar missions, in-situ resource utilization (ISRU) techniques must be developed. In this paper, the use of concentrated light for paving on the Moon by melting the lunar regolith is investigated. As a substitute of the concentrated sunlight, a high-power CO2 laser is used in the experiments. With this set-up, a maximum laser spot diameter of 100 mm can be achieved, which translates in high thicknesses of the consolidated layers. Furthermore, the lunar regolith simulant EAC-1A is used as a substitute of the actual lunar soil. At the end of the study, large samples (approximately 250 × 250 mm) with interlocking capabilities were fabricated by melting the lunar simulant with the laser directly on the powder bed. Large areas of lunar soil can be covered with these samples and serve as roads and landing pads, decreasing the propagation of lunar dust. These manufactured samples were analysed regarding their ineralogical composition, internal structure and mechanical properties. KW - Regolith KW - ISRU KW - Moon KW - Laser KW - Additive manufacturing PY - 2023 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-585985 DO - https://doi.org/10.1038/s41598-023-42008-1 SN - 2045-2322 VL - 13 SP - 1 EP - 10 PB - Springer AN - OPUS4-58598 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Meyer, Lena T1 - Additive Fertigung unter Mikrogravitationsbedingungen für Anwendungen im Weltraum N2 - Präsentation der Aktivitäten an der BAM im Bereich Additive Fertigung unter Mikrogravitationsbedingungen für Anwendungen im Weltraum beim Arbeitsgruppentreffen der AG Werkstoffe & Prozesse vom Netzwerk Space2Motion. T2 - Arbeitsgruppentreffen beim Netzwerk Space2Motion CY - Online meeting DA - 09.11.2022 KW - Additive Fertigung KW - Mikrogravitation PY - 2022 AN - OPUS4-56353 LA - mul AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -