TY - JOUR A1 - Guitton-Spassky, Tiffany A1 - Schade, Boris A1 - Zoister, Christian A1 - Veronese, Eleonora A1 - Rosati, Marta A1 - Baldelli Bombelli, Francesca A1 - Cavallo, Gabriella A1 - Thünemann, Andreas A1 - Ghermezcheshme, Hassan A1 - Makki, Hesam A1 - Netz, Roland R. A1 - Ludwig, Kai A1 - Metrangolo, Pierangelo A1 - Singh, Abhishek Kumar A1 - Haag, Rainer T1 - Fluorinated Hexosome Carriers for Enhanced Solubility of Drugs N2 - Designing nanomaterials for drug encapsulation is a crucial, yet challenging, aspect for pharmaceutical development. An important step is synthesizing amphiphiles that form stable supramolecular systems for efficient drug loading. In the case of fluorinated drugs, these have superior properties and also a tendency toward reduced water solubility. For the first time, we report here fluorinated hexosome carriers made from nonionic dendritic amphiphiles, capable of encapsulating the fluorinated drug Leflunomide with high efficiency (62 ± 3%) and increasing its solubility by 12-fold. We synthesized amphiphiles with varying tail groups (fluorinated/alkylated), and their supramolecular self-assembly was investigated using cryogenic transmission electron microscopy and small-angle X-ray scattering. Furthermore, Leflunomide and its equivalent nonfluorinated counterpart were encapsulated within fluorinated and nonfluorinated assemblies. Self-assembly and encapsulation mechanisms were well supported by coarse-grained molecular simulations, yielding a fundamental understanding of the new systems. KW - PEFAS KW - Small-angle X-ray scattering KW - SAXS KW - Reference method PY - 2025 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-632002 DO - https://doi.org/10.1021/jacsau.5c00198 SN - 2691-3704 VL - 5 IS - 5 SP - 2223 EP - 2236 PB - American Chemical Society (ACS) CY - Washington, DC AN - OPUS4-63200 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -