TY - JOUR A1 - Fischer, Franziska A1 - Joester, Maike A1 - Rademann, K. A1 - Emmerling, Franziska T1 - Survival of the fittest: competitive co-crystal reactions in the ball mill N2 - The driving forces triggering the formation of co-crystals under milling conditions were investigated by using a set of multicomponent competitive milling reactions. In these reactions, different active pharmaceutical ingredients were ground together with a further compound acting as coformer. The study was based on new co-crystals including the coformer anthranilic acid. The results of the competitive milling reactions indicate that the formation of co-crystals driven by intermolecular recognition are influenced and inhibited by kinetic aspects including the formation of intermediates and the stability of the reactants. PY - 2015 DO - https://doi.org/10.1002/chem.201500925 SN - 0947-6539 SN - 1521-3765 VL - 21 IS - 42 SP - 14969 EP - 14974 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-34861 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -