TY - JOUR A1 - Ploska, Ute A1 - Kraus, Werner A1 - Berger, W. A1 - Lugscheider, E. A1 - Nyland, A. T1 - Calcium phosphate-containing materials in the system cati4(PO4)6-CaZr4(PO4)6 for using as coatings on titanium substrates JF - Bioceramics KW - Calciumphosphat KW - Beschichtung KW - Titanträgermaterial PY - 1996 VL - 9 SP - 353 EP - 356 AN - OPUS4-1333 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Kraus, Werner T1 - Pflicht zur Qualität JF - Gefährliche Ladung KW - BAM GGR 001 KW - Rekonditionierung KW - Regelmäßige Wartung und Reparatur an Großpackmitteln PY - 2004 SN - 0016-5808 VL - 49 IS - 7 SP - 8 EP - 9 PB - Storck CY - Hamburg AN - OPUS4-3739 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Hennig, C. A1 - Reck, Günter A1 - Reich, T. A1 - Roßberg, A. A1 - Kraus, Werner A1 - Sieler, J. T1 - EXAFS and XRD investigations of zeunerite and meta-zeunerite JF - Zeitschrift für Kristallographie N2 - In this paper EXAFS was used to determine bond lengths in the structures of zeunerite and meta-zeunerite. The atomic distances between heavy and light scatterers observed using EXAFS in meta-zeunerite deviate approximately 0.1 Å from literature data of single-crystal X-ray diffraction measurements. Because this difference is significant higher than the error limits of EXAFS measurements, the complete crystal structure of meta-zeunerite, Cu[UO2AsO4]2·8 H2O, is revised by X-ray structure analysis. The bond length determinations by EXAFS and the revised XRD data agree within the experimental error limits. In this study EXAFS spectroscopy has proven to be an useful tool for determining precise local bond lengths in the environment of heavy atoms. Moreover, the crystal structure of zeunerite, Cu[UO2AsO4]2·12 H2O, hitherto not been described in the literature, was investigated. Reflex broadening effects and intergrowth relationship between zeunerite and meta-zeunerite show that meta-zeunerite grows in nature due to dehydration of zeunerite. The structural transition from zeunerite to meta-zeunerite is connected with a change in the uranyl arsenate layer arrangement and the crystal water content. PY - 2003 DO - https://doi.org/10.1524/zkri.218.1.37.20776 SN - 0044-2968 VL - 218 IS - 1 SP - 37 EP - 45 PB - Oldenbourg CY - München AN - OPUS4-2291 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Kraus, Werner A1 - Stephan, H. A1 - Reck, Günter T1 - Käfigstrukturen für den Einschluss von Pertechnetat und Perrhenat JF - Zeitschrift für Kristallographie / Supplement issue PY - 2004 SN - 0930-486X VL - 21 SP - 70 PB - Oldenbourg CY - München AN - OPUS4-3489 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Grote, M. A1 - Noll, S. A1 - Noll, B. A1 - Johannsen, B. A1 - Kraus, Werner T1 - Syntheses of novel modified acyclic purine and pyrimidine nucleosides as potential substrates of herpes simplex virus type-1 thymidine kinase for monitoring gene expression JF - Canadian journal of chemistry = Revue canadienne de chimie N2 - Suicide gene therapy with the herpes simplex virus type-1 thymidine kinase gene (HSV-1 tk) is considered to be a promising approach to the treatment of cancer. Making use of the lower specificity of the viral enzyme compared to human thymidine kinase, the therapy involves the administration of antiviral agents (e.g., ganciclovir) as prodrugs to induce enzymatic cell death in those cells that express the transferred gene. 18F-labelled derivatives have been described for monitoring location, duration, and magnitude of the viral kinase enzyme activity by positron emission tomography (PET). Since an optimal radiotracer has not been developed, novel substances were synthesized for monitoring gene expression. A group of 13 nucleoside analogues were synthesized, among them N1-methyl-9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (5) and N1-methyl-9-[(4-hydroxy)-3-hydroxymethylbutyl]guanine (7) as methyl analogues of ganciclovir and penciclovir and their related fluoro compounds (6, 8). Further novel derivatives include N6-methyl-9-[(1,3-dihydroxy-2-propoxy)methyl]-, N6-methyl-9-[(4-hydroxy)-3-hydroxymethylbutyl]adenine (9, 10), as well as the uracil derivatives 5-hydroxy-1-[(1,3-dihydroxy-2-propoxy)methyl]uracil (11), 6-methyl-1-[(1,3-dihydroxy-2-propoxy)-methyl]uracil (12), and its 3-fluoro-derivative (13). KW - Fluorinated nucleoside analogues KW - Gene therapy KW - PET KW - Thymidine kinase PY - 2004 DO - https://doi.org/10.1139/v04-005 SN - 0008-4042 SN - 1480-3291 VL - 82 SP - 513 EP - 523 PB - National Research Council of Canada CY - Ottawa, Ont. AN - OPUS4-3490 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Kniess, T. A1 - Fernandes, C. A1 - Santos, I. A1 - Kraus, Werner A1 - Spies, H. T1 - Silylated mixed-ligand rhenium complexes with the [PNS/S] donor atom set JF - Inorganica Chimica Acta N2 - New oxorhenium complexes with 2-(diphenylphosphanyl)-N-(2-thioethyl)benzamide (H2PNS) and trimethyl-, triethyl- and triphenyl-hydroxyl silylated monodentate thiols are reported. These new complexes have been prepared by reacting [NnBu4][Re(O)Cl4] with the tridentate H2PNS and the corresponding silylated thiol at room temperature. The characterization of the complexes involved elemental analysis, 31P and 1H NMR spectroscopies and X-ray crystallographic analysis for the triethyl-silylated Re complex. KW - Crystal structure KW - Rhenium oxo mixed-ligands complexes PY - 2003 DO - https://doi.org/10.1016/S0020-1693(02)01486-X SN - 0020-1693 SN - 1873-3255 VL - 348 SP - 237 EP - 241 PB - Elsevier Sequoia CY - Lausanne AN - OPUS4-2552 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Jung, C. M. A1 - Kraus, Werner A1 - Leibnitz, Peter A1 - Pietzsch, H.-J. A1 - Kropp, J. A1 - Spies, H. T1 - Synthesis and First Crystal Structure of Rhenium Complexes derived from omega-Functionalized Fatty Acids as Model Compounds of Technetium Tracers for Myocardial Metabolism Imaging JF - European journal of inorganic chemistry N2 - In an attempt to develop new technetium-based radiopharmaceuticals for the noninvasive diagnosis of myocardial metabolism, we have synthesized three examples of novel metal-containing fatty acid derivatives according to the 3+1 mixed-ligand and the Schiff base/tricarbonyl design. The chelates contain the metal core in the oxidation states +5 and +1, respectively, and are attached to the end-position of a fatty acid chain. The complex formation was accomplished by ligand-exchange reactions with three different rhenium precursors, whereas the inactive rhenium metal was utilized as a surrogate of the technetium radionuclide. The molecular structures of the fatty acid complexes 7, 10 and 14 were determined by single-crystal X-ray diffraction analyses and impressively show a general problem in technetium tracer research, namely the significant structural alterations of bioactive molecules by coordination even to small metal chelates. KW - Rhenium KW - Technetium KW - Fatty acids KW - Drug research KW - Radiopharmaceuticals PY - 2002 DO - https://doi.org/10.1002/1099-0682(200205)2002:5<1219::AID-EJIC1219>3.0.CO;2-N SN - 1434-1948 SN - 1099-0682 VL - 2002 IS - 5 SP - 1219 EP - 1225 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-1552 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Drews, A. A1 - Pietzsch, H.-J. A1 - Syhre, R. A1 - Seifert, S. A1 - Varnäs, K. A1 - Hall, H. A1 - Halldin, C. A1 - Kraus, Werner A1 - Karlsson, P. T1 - Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT1A receptor and the alpha-1-adrenergic receptor JF - Nuclear medicine and biology N2 - Tc(III) and Re(III) complexes [M(NS3)(CNR)] (M = Re, 99mTc, NS3 = 2,2?,2?-nitrilotris(ethanethiol), CNR = functionalized isocyanide bearing a derivative of WAY 100635) have been synthesized and characterized. Re was used as Tc surrogate for chemical characterization and in vitro receptor-binding studies. For two representatives subnanomolar affinities for the 5-HT1A as well as for the alpha1-adrenergic receptor were reached. Biodistribution studies in rats of the 99mTc complexes showed brain uptakes between 0.3 and 0.5% ID/organ (5 min p.i.). In vitro autoradiography of one 99mTc representative in sections of post mortem human brain indicate its accumulation in 5-HT1A receptor-rich brain regions. However, addition of the specific 5-HT1A receptor agonist 8-OH-DPAT as well as the alpha1-adrenoceptor antagonist prazosin could not substantially block this tracer accumulation. A preliminary SPET study in a monkey showed negligible brain uptake. KW - 5-HT1A receptor KW - Alpha 1-adrenergic receptor KW - Technetium-99m KW - Rhenium KW - Autoradiography KW - SPET PY - 2002 DO - https://doi.org/10.1016/S0969-8051(02)00296-2 SN - 0883-2897 VL - 29 IS - 4 SP - 389 EP - 398 PB - Elsevier Science Inc. CY - New York, NY AN - OPUS4-1553 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Heimbold, I. A1 - Drews, A. A1 - Kretzschmar, M. A1 - Varnäs, K. A1 - Hall, H. A1 - Halldin, C. A1 - Syhre, R. A1 - Kraus, Werner A1 - Pietzsch, H.-J. T1 - Synthesis, Biological and Autoradiographic Evaluation of a Novel Tc-99m Radioligand derived from WAY 100635 with High Affinity for the 5-HT1A Receptor and the alpha1-Adrenergic Receptor JF - Nuclear medicine and biology N2 - This paper reports the synthesis, biological evaluation, in vitro and ex vivo autoradiography of the first Tc-99m ligand with subnanomolar affinity for the 5-HT1A receptor and a remarkably high affinity for the alpha1-adrenergic receptor. The neutral “3+1” mixed-ligand complex combines 4-(6-mercaptohexyl)-1-(2-methoxyphenyl)piperazine as monodentate and 3-(N-methyl)azapentane-1,5-dithiol as tridentate unit with oxotechnetium(V). The analogous rhenium complex was synthesized for complete structural characterization and used in receptor binding assays. In competition experiments both complexes display subnanomolar affinity for the 5-HT1A receptor (IC500.24 nM for Re, 0.13 nM for Tc) but also very high affinities for the alpha1-adrenergic receptor (IC50 0.05 nM for Re, 0.03 nM for Tc). Biodistribution studies show a brain uptake in rat of 0.22% ID five minutes post injection. In vitro autoradiographic studies in rat brain and postmortem human brain indicate accumulation of the Tc-99m complex in brain areas which are rich in 5-HT1A receptors or in alpha1-adrenergic receptors. This in vitro enrichment can be blocked respectively by the 5-HT1A receptor agonist 8-OH-DPAT or by prazosin hydrochloride, an alpha1-adrenergic receptor antagonist. Ex vivo autoradiographic studies in rats show a slight accumulation of the Tc-99m complex in 5-HT1A receptor-rich areas of the brain, which could not be blocked, as well as in regions rich in alpha1-adrenergic receptors, which could be blocked by prazosin hydrochloride. KW - Serotonin-5-HT1A receptor KW - Tc-99m receptor ligand KW - WAY100635 analogue KW - Ligand synthesis KW - In vitro and ex vivo autoradiography KW - Receptor binding assay PY - 2002 DO - https://doi.org/10.1016/S0969-8051(01)00313-4 SN - 0883-2897 VL - 29 SP - 375 EP - 387 PB - Elsevier Science Inc. CY - New York, NY AN - OPUS4-1554 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Adam, Karin A1 - Kraus, Werner T1 - Untersuchung zur Korrosion von Quecksilberamalgamspiegeln JF - Berichte der Deutschen Mineralogischen Gesellschaft PY - 2002 SN - 0935-123X VL - 14 SP - 9 PB - Schweizerbart CY - Stuttgart AN - OPUS4-1559 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -