TY - JOUR A1 - Koch, J. A1 - Wilrich, Cordula A1 - Gebel, T. T1 - New GHS-Regulation - Implementation of the GHS (Globally Harmonized System) in the EU - What are the changes? KW - GHS KW - Dangerous chemicals KW - Classification PY - 2008 VL - 1 SP - 10 EP - 11 PB - Vogel CY - Würzburg AN - OPUS4-17123 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gebel, T. A1 - Koch, J. A1 - Wilrich, Cordula T1 - Global harmonisiert in Europa KW - GHS KW - Chemikalien KW - Einstufung KW - CLP-Verordnung PY - 2009 SN - 1439-9598 SN - 1521-3854 VL - 57 IS - 4 SP - 417 EP - 418 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-19413 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Beckmann, Jörg A1 - Richter, Heike A1 - Zscherpel, Uwe A1 - Ewert, Uwe A1 - Weinzierl, J. A1 - Schmidt, L.-P. A1 - Rutz, F. A1 - Koch, M. A1 - Richter, H. A1 - Hübers, H.-W. T1 - Imaging Capability of Terahertz and Millimeter-Wave Instrumentations for NDT of Polymer Materials T2 - 9th European Conference on NDT CY - Berlin, Germany DA - 2006-09-25 KW - Time domain spectroscopy KW - Air coupled ultrasound KW - Pulsed THz radiation system KW - Pulse compression KW - THz imaging PY - 2006 SN - 3-931381-86-2 SP - 1(?) EP - 9(?) PB - European Federation for Non-Destructive Testing CY - Berlin AN - OPUS4-13875 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gschwind, S. A1 - Flamigni, L. A1 - Koch, J. A1 - Borovinskaya, O. A1 - Groh, S. A1 - Niemax, Kay A1 - Günther, D. T1 - Capabilities of inductively coupled plasma mass spectrometry for the detection of nanoparticles carried by monodisperse microdroplets N2 - Recently, first analyses of single sub-micrometre particles, embedded in liquid droplets, by inductively coupled plasma optical emission spectrometry (ICP-OES) with a size-equivalent detection limit of several hundred nanometres were reported.1,2 To achieve lower detection limits which might allow for the analysis of particles in the nanometre size range a more sensitive technique such as mass spectrometry (MS) is required. Various modifications of particle delivery and data acquisition systems commonly used were carried out to install a setup adequate for ICP-MS detection. These modifications enabled us to supply droplets generated by a commercial microdroplet generator (droplet size: 30–40 µm) with nearly 100% efficiency and high uniformity to the ICP. Analyses were performed using both standard solutions of dissolved metals at concentrations of 1 (Ag), 2 (Au), 5 (Au), or 10 (Cu) mg L-1 and highly diluted suspensions of gold and silver nanoparticles with sizes below 110 nm. In doing so, detection efficiencies of 10-6 counts per atom could be achieved while size-related limits of quantification were found to be 21 nm and 33 nm for gold and silver, respectively. Furthermore, the advantages of utilizing microdroplet generators vs. conventional nebulizers for nanoparticle analyses by ICP-MS are discussed. PY - 2011 DO - https://doi.org/10.1039/c0ja00249f SN - 0267-9477 SN - 1364-5544 VL - 26 IS - 6 SP - 1166 EP - 1174 PB - Royal Society of Chemistry CY - London AN - OPUS4-25606 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Traub, Heike A1 - Wälle, M. A1 - Koch, J. A1 - Panne, Ulrich A1 - Matschat, Ralf A1 - Kipphardt, Heinrich A1 - Günther, D. T1 - Evaluation of different calibration strategies for the analysis of pure copper and zinc samples using femtosecond laser ablation ICP-MS N2 - Solution-doped metal powder pellets as well as aspirated liquids were used as calibration samples to analyze pure copper and zinc certified reference materials (CRMs) by femtosecond laser ablation ICP-MS. It was demonstrated that calibration by copper pellets resulted in relative deviations up to 20%, whereas fs-LA-ICP-MS among copper-based CRMs led to inaccuracies in the same range unless nominal mass fractions were chosen to be <3 mg/kg. Calibration by zinc pellets generally provided better accuracy. Depending on the analyte considered, deviations below 10% were obtained even for mass fractions close to the limit of quantification. Our data, therefore, indicate solution-doped metal powder pellets to be suitable as calibration samples for fs-LA-ICP-MS of metals. Furthermore, the utilization of liquid standards for calibration was found to result in stronger deviations of up to 50% for both copper and zinc samples which, in addition, turned out to be dependent on the plasma conditions. KW - Laser ablation KW - ICP-MS KW - Calibration KW - Copper KW - Zinc KW - Metal PY - 2009 DO - https://doi.org/10.1007/s00216-009-3061-9 SN - 1618-2642 SN - 1618-2650 VL - 395 IS - 5 SP - 1471 EP - 1480 PB - Springer CY - Berlin AN - OPUS4-20402 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Drzymala, Sarah A1 - Binder, J. A1 - Brodehl, Antje A1 - Penkert, M. A1 - Rosowski, M. A1 - Garbe, L.-A. A1 - Koch, Matthias T1 - Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone N2 - Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, α-cis-zearalenol and β-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone. KW - Zearalenone KW - Mycotoxin KW - MCF-7 KW - E-screen assay KW - Estrogenicity KW - Isomerization PY - 2015 DO - https://doi.org/10.1016/j.toxicon.2015.08.027 SN - 0041-0101 SN - 1879-3150 VL - 105 SP - 10 EP - 12 PB - Elsevier CY - Oxford [u.a.] AN - OPUS4-34167 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Kuner, Maximilian A1 - Lisec, Jan A1 - Mauch, Tatjana A1 - Konetzki, J. A1 - Haase, H. A1 - Koch, Matthias T1 - Quantification of Ergot Alkaloids via Lysergic Acid Hydrazide—Development and Comparison of a Sum Parameter Screening Method N2 - Ergot alkaloids are a group of mycotoxins occurring in products derived from various grasses (e.g., rye) and have been regulated in the EU recently. The new maximum levels refer to the sum of the six most common ergot alkaloids in their two stereoisomeric forms in different food matrices. Typically, these twelve compounds are individually quantified via HPLC-MS/MS or -FLD and subsequently summed up to evaluate food safety in a time-consuming process. Since all these structures share the same ergoline backbone, we developed a novel sum parameter method (SPM) targeting all ergot alkaloids simultaneously via lysergic acid hydrazide. After extraction and clean-up, in analogy to the current European standard method EN 17425 (ESM) for ergot alkaloid quantitation, the samples were derivatized by an optimized hydrazinolysis protocol, which allowed quantitative conversion after 20 min at 100 °C. The new SPM was evaluated against another established HPLC-FLD-based method (LFGB) and the HPLC-MS/MS-based ESM using six naturally contaminated rye and wheat matrix reference materials. While the SPM provided comparable values to the ESM, LFGB showed deviating results. Determined recovery rates, limits of detection and quantification of all three employed methods confirm that the new SPM is a promising alternative to the classical approaches for ergot alkaloid screening in food. KW - Ergot alkaloids KW - Sum Parameter KW - Mycotoxins KW - Derivatization KW - Hydrazinolysis PY - 2023 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-573968 DO - https://doi.org/10.3390/molecules28093701 SN - 0015-2684 VL - 28 IS - 9 SP - 3701 PB - MDPI CY - Basel AN - OPUS4-57396 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Koch, Matthias A1 - Gebauer, J. T1 - Total Synthesis of (+-)-Trichodiene T2 - 1st European Conference on Natural Products CY - Frankfurt am Main, Germany DA - 2013-09-22 PY - 2013 AN - OPUS4-29483 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Weiz, S. A1 - Marten, S. A1 - Heinze, J. A1 - Drzymala, Sarah A1 - Koch, Matthias T1 - Unpolarer Analyt, unpolare Matrix: das Mykotoxin Zearalenon in Öl N2 - Mit einer automatisierten Online-Festphasenextraktion ist das Schimmelpilzgift Zearalenon in Speiseöl mit HPLC direkt bestimmbar. Die Probenvorbereitung ist hochselektiv und eignet sich für die Routinekontrolle des EU-Grenzwerts. KW - Mykotoxine KW - HPLC KW - Online-SPE KW - Hydrazine PY - 2013 SN - 1439-9598 SN - 1521-3854 VL - 61 IS - Dezember SP - 1241 EP - 1243 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-29811 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Sebald, M. A1 - Gebauer, J. A1 - Koch, Matthias T1 - Concise Synthesis of Alternariol and Alternariol-9-monomethyl ether as well as their D3-Isotopologues N2 - Abstract Alternariol (AOH) and alternariol-9-monomethyl ether (AME) are two secondary metabolites of Alternaria fungi which can be found in various foodstuff like tomatoes, nuts, and grains. Due to their toxicity and potential mutagenic activity the need for the development of high-throughput methods for the supervision of AOH- and AME-levels is of increasing interest. As the availability of both native and labeled AOH and AME analytical standards is very limited we herein wish to present a novel concise approach towards their synthesis employing a ruthenium-catalyzed ortho-arylation as the key step. Finally, we demonstrate their suitability as internal standards in stable-isotope dilution assay (SIDA)-HPLC-MS/MS analysis commonly used for the quantification of the natural products in food and feed. KW - Mycotoxins KW - Food Analysis KW - Emerging contaminants PY - 2021 DO - https://doi.org/10.1055/a-1698-8328 SN - 0039-7881 VL - 54 IS - 19 SP - 4285 EP - 4293 PB - Thieme AN - OPUS4-53994 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gebauer, J. A1 - Werneburg, Martina A1 - Koch, Matthias T1 - Improved synthesis of (+-)-trichodiene - a volatile marker for trichothecene mycotoxins N2 - Trichodiene is the first and only volatile intermediate in the biosynthesis of Fusarium mycotoxins and its detection in the gas-phase might therefore be of potential interest as a marker for food safety analysis. We herein present an improved diastereoselective synthesis of trichodiene which can be used as an analytical standard for a headspace gas chromatography / mass spectrometry method to be developed. KW - Trichodiene KW - Trichothecenes KW - Mycotoxins KW - Fusarium KW - Food safety KW - Synthesis PY - 2014 SN - 1934-578X SN - 1555-9475 VL - 9 IS - 6 SP - 741 EP - 744 PB - NPC CY - Westerville, Ohio, USA AN - OPUS4-30909 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -