TY - CONF A1 - Karrasch, S. A1 - Jörres, R. A1 - Ehret, M. A1 - Herbig, B. A1 - Schierl, R. A1 - Seeger, Stefan A1 - Langner, J. A1 - Nowak, D. ED - Hildenbrandt, Sibylle ED - Rieger, Monika A. T1 - Untersuchung möglicher gesundheitlicher Gefährdungen durch Drucker- und Kopierer-Emissionen Teil 1 und 2 N2 - Teil 1: In der Öffentlichkeit werden immer wieder mögliche gesundheitliche Auswirkungen von Laserdruckeremissionen diskutiert. Um diese möglichen Auswirkungen genauer zu analysieren, wurden die Effekte 75-minütiger Expositionen von sogenannten Low-Emittern (LE, Untergrund 2000-4000 UFP/cm3) gegenüber High-Emittern (HE, 100.000 UFP/cm3) untersucht. Teil 2: Mögliche gesundheitliche Auswirkungen von Laserdruckeremissionen sind immer wieder Gegenstand öffentlicher Aufmerksamkeit. Die dabei auftretenden potenziellen psychologischen Aspekte, wurden in einem standardisierten Szenario mittels 75-minütiger Expositionen gegenüber Low-Emittern (LE, Untergrund 2000-4000 UFP/cm3) und High-Emittern (HE, 100.000 UFP/cm3) untersucht. T2 - 55. Jahrestagung der DGAUM 2015 CY - Munich, Germany DA - 18.03.2015 KW - Gesundheitsgefährdung KW - Laserdrucker KW - Bürogeräte KW - Partikel KW - Emissionen PY - 2015 SN - 978-3-9817007-1-8 SP - 357 EP - 489 PB - Geschäftsstelle der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e. V. CY - München AN - OPUS4-38751 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Herbig, B. A1 - Jörres, R. A. A1 - Schierl, R. A1 - Simon, M. A1 - Langner, Jeanette A1 - Seeger, Stefan A1 - Nowak, D. A1 - Karrasch, S. T1 - Psychological and cognitive effects of laser printer emissions: A controlled exposure study N2 - The possible impact of ultrafine particles from laser printers on human health is controversially discussed although there are persons reporting substantial symptoms in relation to these emissions. A randomized, single-blinded, cross-over experimental design with two exposure conditions (high-level and low-level exposure) was conducted with 23 healthy subjects, 14 subjects with mild asthma, and 15 persons reporting symptoms associated with laser printer emissions. To separate physiological and psychological effects, a secondary physiologically based categorization of susceptibility to particle effects was used. In line with results from physiological and biochemical assessments, we found no coherent, differential, or clinically relevant effects of different exposure conditions on subjective complaints and cognitive performance in terms of attention, short-term memory, and psychomotor performance. However, results regarding the psychological characteristics of participants and their situational perception confirm differences between the participants groups: Subjects reporting symptoms associated with laser printer emissions showed a higher psychological susceptibility for adverse reactions in line with previous results on persons with multiple chemical sensitivity or idiopathic environmental intolerance. In conclusion, acute psychological and cognitive effects of laser printer emissions were small and could be attributed only to different participant groups but not to differences in exposure conditions in terms of particle number concentrations. KW - Cognitive performance KW - Exposure KW - Idiopathic environmental intolerance KW - Laser printer emission KW - Multiple chemical sensitivity KW - Subjective complaints PY - 2018 DO - https://doi.org/10.1111/ina.12429 SN - 1600-0668 SN - 0905-6947 VL - 28 IS - 1 SP - 112 EP - 124 PB - John Wiley & Sons, Inc. CY - 111 RIVER ST, HOBOKEN 07030-5774, NJ USA AN - OPUS4-43945 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Karrasch, Stefan A1 - Simon, M. A1 - Herbig, Britta A1 - Langner, Jeanette A1 - Seeger, Stefan A1 - Kronseder, A. A1 - Peters, S. A1 - Dietrich-Gümperlein, G. A1 - Schierl, R. A1 - Nowak, D. A1 - Jörres, R.A. ED - Nazaroff, William T1 - Health effects of laser printer emissions: a controlled exposure study N2 - Ultrafine particles emitted from laser printers are suspected to elicit adverse health effects. We performed 75-minute exposures to emissions of laser printing devices (LPDs) in a standardized, randomized, cross- over manner in 23 healthy subjects, 14 mild, stable asthmatics, and 15 persons reporting symptoms associated with LPD emissions. Low-level exposures (LLE) ranged at the particle background (3000 cm−3) and High-level exposures (HLE) at 100 000 cm−3. Examinations before and after exp sures included spirometry, body plethysmography, transfer factors for CO and NO (TLCO, TLNO), bronchial and alveolar NO, cytokines in serum and nasal secretions (IL-1β, IL-5, IL-6, IL-8, GM-CSF, IFNγ, TNFα), serum ECP, and IgE. Across all participants, no statistically significant changes occurred for lung mechanics and NO. There was a decrease in volume-related TLNO that was more pronounced in HLE, but the difference to LLE was not significant. ECP and IgE increased in the same way after exposures. Nasal IL-6 showed a higher increase after LLE. There was no coherent pattern regarding the responses in the participant subgroups or single sets of variables. In conclusion, the experimental acute responses to short but very high-level LPD exposures were small and did not indicate clinically relevant effects compared to low particle number concentrations. KW - Emission KW - Exposure KW - Laser printer KW - Lung function KW - Respiratory health KW - Ultrafine particles PY - 2017 DO - https://doi.org/10.1111/ina.12366 SN - 1600-0668 VL - 27 IS - 4 SP - 753 EP - 765 PB - John Wiley & Sons Ltd. CY - London AN - OPUS4-42593 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - RPRT A1 - Seeger, Stefan A1 - Langner, Jeanette A1 - Nowak, D. A1 - Jörres, R.A. A1 - Karrasch, S. A1 - Ehret, M. A1 - Herbig, B. A1 - Schierl, R. T1 - Untersuchung möglicher gesundheitlicher Gefährdungen durch Drucker- und Kopierer-Emissionen KW - Bürogeräte KW - Laserdrucker KW - Partikelemission KW - Aerosol KW - Gesundheitliche Gefährdung KW - In-vivo-Studie PY - 2014 UR - http://www.dguv.de/Projektdatenbank/0294A/3228509v1.pdf SP - 1 EP - 238 CY - Berlin ET - Abschlussbericht der Projektpartner zum DGUV-Projekt (Kennziffer FP 294) AN - OPUS4-31335 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Jörres, R. A1 - Ehret, M. A1 - Karrasch, S. A1 - Herbig, B A1 - Schierl, R. A1 - Seeger, Stefan A1 - Langner, J. A1 - Nowak, D. T1 - Respiratorische Effekte von Drucker- und Kopierer-Emissionen – eine kontrollierte Expositionsstudie N2 - Die möglichen gesundheitlichen Auswirkungen von Laserdruckeremissionen sind immer wieder Gegenstand von Aufmerksamkeit. Wir untersuchten die Effekte 75-minütigerExpositionen gegenüber Low-Emittern (LE, Untergrund 2000 – 4000 UFP/cm3) und High-Emittern (HE, 100.000 UFP/cm3). T2 - 56. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. CY - Berlin, Germany DA - 18.03.2015 KW - Expositionsstudie in-vivo KW - Bürogeräte KW - Emissionen KW - Partikel PY - 2015 DO - https://doi.org/10.1055/s-0035-1544873 VL - 69-V516 SP - V516 PB - Thieme CY - Stuttgart AN - OPUS4-38752 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Karrasch, Andrea T1 - Festkörper-NMR Untersuchungen an flammgeschützten Polymeren T2 - Seminar "Festkörper-NMR-Methoden und Anwendungen in der Materialforschung", Universität Tübingen CY - Bad Hindelang, Germany DA - 2008-07-13 PY - 2008 AN - OPUS4-17899 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Karrasch, Andrea A1 - Jäger, Christian A1 - Karakawa, M. A1 - Nakatsubo, F. A1 - Potthast, A. A1 - Rosenau, T. T1 - Solid-state NMR studies of methyl celluloses. Part 1: regioselectively substituted celluloses as standards for establishing an NMR data basis N2 - Three methyl celluloses with completely uniform substitution pattern, 2-O-methyl cellulose (1), 3-O-methyl cellulose (2) and 6-O-methyl cellulose (3), were prepared according to the cationic ring opening polymerization approaches starting from substituted 1,2,4-orthopivalate derivatives of D-glucose. These samples allowed for the first time to sort out the methyl substitution effects on solid-state NMR chemical shifts and relaxation. Dipolar dephasing experiments allowed the detection and assignment (1H, 13C) of the methyl groups. In 1 and 2, these resonances overlapped with those of C-6, whereas in 3, the methyl signal experienced a low-field shift into the region of C-2,3,5. 13C T1 experiments were used to verify different relaxation behavior of the carbon sites, particularly the short relaxation time of at the carbon substitution site next to the methyl groups. This effect was used to unambiguously identify the 13C chemical shifts of the carbons carrying the methoxyl substituent, although they overlap with all resonances in the C-2,3,5 region. The data obtained for the standard samples with uniform substitution will now be used as the basis for determining methylation patterns and substitution degree in commercial methyl celluloses. KW - Methyl cellulose KW - Solid-state NMR KW - CPMAS NMR KW - Substituent distribution KW - Substitution pattern KW - Cationic ring opening polymerization KW - Methylation PY - 2009 DO - https://doi.org/10.1007/s10570-008-9247-z SN - 0969-0239 SN - 1572-882X VL - 16 SP - 129 EP - 137 PB - Chapman & Hall CY - London AN - OPUS4-18913 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Karrasch, Andrea A1 - Jäger, Christian A1 - Saake, B. A1 - Potthast, A. A1 - Rosenau, T. T1 - Solid-state NMR studies of methyl celluloses. Part 2: Determination of degree of substitution and O-6 vs. O-2/O-3 substituent distribution in commercial methyl cellulose samples N2 - Solid state NMR spectroscopy was applied to determine the overall degree of substitution (DS) and the degrees of substitution at C-6 (DSC-6) and C-2/3 (DSC-2/3). Four commercial methyl cellulose samples were used, having a DS between 0.51 and 1.96 as determined by wet-chemical analysis. The strategy and optimization of the NMR data acquisition as well as the data evaluation procedures are explained in detail. Optimization of the approach mainly comprised (a) maximizing the signal by choice of NMR probe, MAS spinning frequency and B0 field, (b) minimizing the measurement time by a Torchia-type experiment and (c) suppressing probe background by rotor-synchronized echo detection. Data evaluation used simply the integration of three different spectral ranges in the 13C NMR spectrum. The results of the experiments were in good agreement with the wet-chemical data. The NMR approach takes about the same analysis time as the conventional hydrolysis/chromatography analysis. However, it is a generally applicable and simple alternative without need for an extended sample preparation which is most useful if wet-chemical/chromatographic analyses are undesired or unavailable. Further studies have to concentrate on the validation of the analytical method and application to a larger sample array. KW - Methyl cellulose KW - Solid-state NMR KW - 13C CPMAS NMR KW - Rotor-synchronized echo sequence KW - Substituent distribution KW - Substitution pattern KW - Degree of substitution PY - 2009 DO - https://doi.org/10.1007/s10570-009-9304-2 SN - 0969-0239 SN - 1572-882X VL - 16 IS - 6 SP - 1159 EP - 1166 PB - Chapman & Hall CY - London AN - OPUS4-21130 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Karrasch, Andrea A1 - Jäger, Christian T1 - Thermal decomposition of PDMS in flame-retarded bisphenol-A polycarbonate: A solid-state NMR investigation T2 - GDCh-Tagung Magnetische Resonanz 2008 CY - Regensburg, Germany DA - 2008-09-22 PY - 2008 AN - OPUS4-17831 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Karrasch, Andrea A1 - Jäger, Christian T1 - Solid-state NMR Studies of Methyl Celluloses T2 - The Alpine Conference on Solid-State NMR CY - Chamonix, France DA - 2009-09-13 PY - 2009 AN - OPUS4-19372 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CHAP A1 - Pikacz, E. A1 - Seefeldt, Henrik A1 - Schartel, Bernhard A1 - Braun, Ulrike A1 - Karrasch, Andrea A1 - Jäger, Christian T1 - Flame retardancy in PC/Silicone rubber blends using BDP and additional additives T2 - 20th Annual conference on recent advances in flame retardancy of polymeric materials CY - Stamford, CT, USA DA - 2009-06-01 KW - Flame retardancy KW - PC blend KW - Aryl phosphate PY - 2009 SN - 1-59623-509-8 VL - 20 IS - Chapter IV-B SP - 236 EP - 246 CY - Wellesley, MA, USA AN - OPUS4-20703 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Jäger, Christian A1 - Maltsev, Sergey A1 - Karrasch, Andrea T1 - Progress of Structural Elucidation of Amorphous Calcium Phosphate (ACP) and Hydroxyapatite (HAp): Disorder and Surfaces as Seen by Solid State NMR KW - Hydroxyapatite KW - Amorphous calcium phosphate KW - Structural investigation KW - Surface KW - NMR PY - 2006 VL - 18 IS - 1 SP - 69 EP - 72 AN - OPUS4-11008 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Jäger, Christian A1 - Maltsev, Sergey A1 - Malz, Frank A1 - Karrasch, Andrea A1 - Altenburg, Wolfgang T1 - Nanoskalige Calciumphosphate, Oberflächenstrukturen und Wechselwirkung mit organischen Molekülen: Was kann die NMR? PY - 2005 SN - 1616-0177 SN - 0011-8656 VL - 6 IS - 3 SP - 232 PB - Verl. Neuer Merkur CY - München AN - OPUS4-11609 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Karrasch, Andrea T1 - Thermal decomposition of PDMS in flame-retarded Bisphenol-a Polycarbonate: a solid-state NMR investigation T2 - GDCh Tagung Magnetische Resonanz 2009 CY - Dresden, Germany DA - 2009-09-21 PY - 2009 AN - OPUS4-20005 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -