TY - CONF A1 - Mielke, Johannes A1 - Hodoroaba, Vasile-Dan T1 - Evaluation and selection of techniques and methodologies to support the implementation of the EC recommendation for a definition of nanomaterial T2 - Synergy Workshop NanoDefine with other NSC (Nano Safety Cluster) Projects CY - Copenhagen, Denmark DA - 2014-06-06 PY - 2014 AN - OPUS4-30958 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - RPRT A1 - Hodoroaba, Vasile-Dan A1 - Mielke, Johannes T1 - Templates for nanomaterial characterisation of tier 1 and tier 2 measurement methods N2 - The EU FP7 NanoDefine project was launched in November 2013 and will run until October 2017. The Project is dedicated to support the implementation of the EU Recommendation on the Definition of Nanomaterial by the provision of the required analytical tools and respective guidance. Main goal is to develop a novel tiered approach consisting of (i) rapid and cost-efficient screening methods and (ii) confirmatory measurement methods. The "NanoDefiner" eTool will guide potential end-users, such as concerned industries and regulatory bodies as well as enforcement and contract laboratories, to reliably classify if a material is nano or not. To achieve this objective, a comprehensive inter-laboratory evaluation of the performance of current characterisation techniques, instruments and software is performed. Instruments, software and methods are further developed. Their capacity to reliably measure the size of particulates in the size range 1-100 nm and above (according to the EU definition) is validated. Technical reports on project results are published to reach out to relevant stakeholders, such as policy makers, regulators, industries and the wider scientific community, to present and discuss our goals and results, to ensure a continuous exchange of views, needs and experiences obtained from different fields of expertise and application, and to finally integrate the resulting feedback into our ongoing work on the size-related classification of nanomaterials. KW - Nanomaterial KW - Measurement method KW - Screening methods KW - Confirmatory methods PY - 2014 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-389827 UR - http://www.nanodefine.eu/index.php/downloads/nanodefine-technical-reports SP - 1 EP - 74 PB - The NanoDefine Consortium CY - Wageningen, The Netherlands AN - OPUS4-38982 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Mielke, Johannes A1 - Hodoroaba, Vasile-Dan T1 - The Project NanoDefine T2 - International summer workshop "NANOSCIENCE meets METROLOGY" CY - Erice, Italy DA - 2015-07-27 PY - 2015 AN - OPUS4-33892 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Mielke, Johannes A1 - Hodoroaba, Vasile-Dan A1 - Ullmann, Ch. A1 - Babick, F. A1 - Weigel, St. T1 - Evaluation and Comparison of Particle Sizing Techniques within the EC/FP7 Project NanoDefine T2 - International summer workshop "NANOSCIENCE meets METROLOGY" CY - Erice, Italy DA - 2015-07-27 PY - 2015 AN - OPUS4-33893 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Mielke, Johannes A1 - Babick, F. A1 - Wohlleben, W. A1 - Ullmann, C. A1 - Hodoroaba, Vasile-Dan T1 - NanoDefine, Work package 3: The methods evaluation hub T2 - EuoNanoForum 2015 CY - Riga, Lativa DA - 2015-06-10 PY - 2015 AN - OPUS4-33401 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Mielke, Johannes A1 - Rades, Steffi A1 - Ortel, Erik A1 - Wirth, Thomas A1 - Salge, T. A1 - Unger, Wolfgang A1 - Hodoroaba, Vasile-Dan T1 - Advanced analytical scanning electron microscopy for the characterization of nanoparticles T2 - EuoNanoForum 2015 CY - Riga, Lativa DA - 2015-06-10 PY - 2015 AN - OPUS4-33402 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Mielke, Johannes A1 - Babick, F. A1 - Ullmann, Ch. A1 - Hodoroaba, Vasile-Dan T1 - Evaluierung der Messmethoden zur Implementierung der EU-Empfehlung zur Definition von Nanomaterialien im Projekt "NanoDefine" T2 - Workshop von Bundesbehörden/VCI/VdMi "Messstrategien und Messmethoden für Nanomaterialien" CY - Berlin, Germany DA - 2015-09-08 PY - 2015 AN - OPUS4-34064 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - RPRT A1 - Hodoroaba, Vasile-Dan A1 - Mielke, Johannes T1 - Techniques evaluation report for selection of characterisation methods N2 - This report is the result of a comprehensive study on the available CMs which come potentially in question for the reliable analysis of the number based size distribution of a nanomaterial according to the EC recommendation for a definition of nanomaterial. Based on the performance criteria already established in NanoDefine the potential CMs are evaluated according to studies available in the literature as well as following the expertise of the NanoDefine consortium partners. The specific advantages and disadvantages of each method with respect to its applicability to the scope of NanoDefine are particularly highlighted. An CM evaluation table is produced so that the mostly suited CMs with respect to the EC definition can be grouped and recommended to the corresponding NanoDefine work packages for further specific development (improvement and adaption), or for direct validation and standardisation, respectively. The actual evaluation report including the recommended CMs will be revised and, if necessary, eventually updated at the mid time of the project. The update will be jointly discussed in the NanoDefine consortium on the basis of the results of testing the methods on the NanoDefine real world materials. KW - Nanomaterial KW - Characterization method KW - EC definition PY - 2015 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-389473 UR - http://www.nanodefine.eu/publications/reports/NanoDefine_TechnicalReport_D3.1.pdf SP - D3.1, 1 EP - 57 CY - Wageningen, The Netherlands AN - OPUS4-38947 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - RPRT A1 - Rauscher, H. A1 - Mech, A. A1 - Gaillard, C. A1 - Stintz, M. A1 - Wohlleben, W. A1 - Weigel, St. A1 - Ghanem, A. A1 - Hodoroaba, Vasile-Dan A1 - Babick, F. A1 - Mielke, Johannes T1 - Recommendations on a Revision of the EC Definition of Nanomaterial Based on Analytical Possibilities N2 - In October 2011 the European Commission (EC) published a "Recommendation on the definition of nanomaterial" (2011/696/EU), to promote consistency in the interpretation of the term "nanomaterial" for legislative and policy purposes in the EU. The EC NM Definition includes a commitment to its review in the light of experience and of scientific and technological developments. This review is ongoing in 2015 and as a contribution to the review the Joint Research Centre of the European Commission (JRC) has already developed a series of three scientific-technical reports with the title: “Towards a review of the EC Recommendation for a definition of the term nanomaterial” which provides to the EC policy services science-based options on how the definition could be revised or supported with additional guidance. The overarching nature and wide scope of the EC NM Definition, as it does not exclude a priori any particulate material regardless the state, form and size, creates many analytical challenges in its imple-mentation for all stakeholders, including enterprises and regulators. The NanoDefine project has as core objective to support the implementation of the EC NM Definition. In this report key aspects of the EC NM Definition are addressed, with the goal to improve the implement-ability of the EC NM Definition. These aspects are presented and discussed based on the results of two years of research performed within the framework of the project. As a result this report assesses how well the requirements of the EC NM Definition can be fulfilled with currently available analytical possi-bilities. It presents recommendations and options on a revision of the EC NM Definition to improve the implementability of the definition based on currently available analytical possibilities, according to the state of the art of mid-2015. Of the technical issues considered in this report, the following seem to deserve the most attention in terms of clarification of the definition and/or provision of additional implementation guidance:  The term ‘external dimension’. A clear definition of 'External dimension' should be included in the text of the EC NM definition and more precise guidance on what is considered as an external dimension and how to properly character-ise it should be provided.  The ‘number based particle size distribution‘. The EC NM Definition uses a threshold related to the number based size distribution of particles. Yet most of the easily available techniques provide a mass-, volume- or scattered light intensity-based size distribution which needs to be converted into a number based distribution to be used for regulatory pur-poses. A specific guidance on the conditions under which these methods can be used to identify a na-nomaterial by employing appropriate quantity or metrics conversion should be provided.  The ‘polydispersity‘ and ‘upper size limit‘ Polydispersity is a challenge for the measurement of particle size distribution for the EC NM definition, specifically for materials with high polydispersity index and broad size distribution especially when the volume or mass of the fraction containing particles below 100 nm is very small. Therefore a dedicated guidance should be provided that allows applying an upper size limit in measurements and particle statistics. KW - Nanomaterial KW - EU Definition of nanomaterial KW - Nanoparticles PY - 2015 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-432339 UR - http://www.nanodefine.eu/publications/reports/NanoDefine_TechnicalReport_D7.10.pdf SP - 1 EP - 68 PB - The NanoDefine Consortium CY - Wageningen, The Netherlands AN - OPUS4-43233 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Mielke, Johannes A1 - Dohányosová, P. A1 - Lopez, S. A1 - Hodoroaba, Vasile-Dan T1 - Electrospray deposition of nanoparticles on TEM grids N2 - The authors have tested the prototype of an electrospray deposition system developed by the company RAMEM under its trademark IONER. To test the prototype and assess its performance, several materials have been sprayed onto TEM grids and the resulting particle distributions were compared to more traditional sample preparation strategies like the “drop on grid” method. Operation parameters such as the sample flow-rate, capillary – substrate distance, electric field strength and sampling period length have been optimized. It was found that the particles deposited by electrospray generally show a much more homogeneous spatial distribution on the substrate and a substantial increase of the number of single particles, which are much better suited to an automatic image evaluation procedure than the agglomerated particles observed otherwise. The applicability of the technique to a broad range of materials is demonstrated by various examples, but also the influence of the substrate, the choice of the particular TEM grid, on the obtained spatial particle distribution is assessed. KW - Electrspray deposition KW - Electron microscopy KW - Nanoparticles KW - Sample preparation PY - 2016 UR - https://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/electrospray-deposition-of-nanoparticles-on-tem-grids/459E634B7F74D474A19E15E69DA82E5D DO - https://doi.org/10.1017/S1431927616010072 SN - 1431-9276 SN - 1435-8115 VL - 22 IS - Suppl 3 SP - 1846 EP - 1847 PB - Cambridge AN - OPUS4-38436 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -