TY - GEN A1 - Gunella, F. A1 - Kunisch, E. A1 - Maenz, S. A1 - Horbert, V. A1 - Xin, L. A1 - Mika, J. A1 - Borowski, J. A1 - Bischoff, S. A1 - Schubert, H. A1 - Sachse, A. A1 - Illerhaus, Bernhard A1 - Günster, Jens A1 - Bossert, J. A1 - Jandt, K. D. A1 - Plöger, F. A1 - Kinne, R. W. A1 - Brinkmann, O. A1 - Bungartz, M. ED - Carragee, T1 - The GDF5 mutant BB-1 enhances the bone formation induced by an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia N2 - BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic Proteins (eg, GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty and kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and to support complete bone regeneration. The biologically optimized GDF5 Mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming CPC containing low-dose BB-1 in a sheep lumbar osteopenia model. STUDY DESIGN/ SETTING: This is a prospective experimental animal study. METHODS: Bone defects (diameter 5 mm) were generated in aged, osteopenic female sheep and were filled with fiber-reinforced CPC alone (L4; CPC+fibers) or with CPC containing different dosages. KW - Bone morphogenetic protein; KW - Bone regeneration; KW - Micro-Computed-Tomography; KW - Calcium phosphate cement; KW - GDF-5 mutant; KW - Large animal model sheep; KW - Osteoporotic vertebral fracture PY - 2018 U6 - https://doi.org/10.1016/j.spinee.2017.10.002 SN - 1529-9430 SN - 1878-1632 VL - 18 IS - 2 SP - 357 EP - 369 PB - Elsevier CY - New York AN - OPUS4-44561 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Zerbst, Uwe A1 - Madia, Mauro A1 - Schork, B. A1 - Kaffenberger, M. A1 - Oechsner, M. A1 - Kucharzcyk, P. A1 - Hensel, J. A1 - Bernhard, J. A1 - Tchuindjang, D. T1 - The effect of the local and global weld geometry as well as material defects on crack initiation and fatigue strength N2 - The paper provides an application of the IBESS approach to the investigation of the influence of various parameters of the global and local weld geometry as well as material defects on the fatigue strength of weldments. For this purpose, the global weld parameters, such as the weld toe radius, the flank angle, the excess weld metal, local secondary notches (in the present study as a measure of surface imperfections) and inclusions sizes have been determined as statistical distributions for different joint types and geometries and two steels of different strengths. The results are in line with literature data and reveal the potential of the theoretical approach to predict the correct trends. The combination with an advanced weld quality system has been demonstrated to be possible. KW - Weldments KW - Fatigue strength KW - Fracture mechanics KW - Weld geometry KW - Inclusions KW - Multiple crack initiation PY - 2018 U6 - https://doi.org/10.1016/j.engfracmech.2017.07.001 SN - 0013-7944 SN - 1873-7315 VL - 198 SP - 103 EP - 122 PB - Elsevier AN - OPUS4-46858 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Velencoso, M. M. A1 - Battig, Alexander A1 - Markwart, J. C. A1 - Schartel, Bernhard A1 - Wurm, F. R. T1 - Molecular firefighting – How modern phosphorus chemistry can help solve the challenge of flame retardancy N2 - The ubiquity of polymeric materials in daily life Comes with an increased fire risk, and sustained research into efficient flame retardants is key to ensuring the safety of the populace and material goods from accidental fires. Phosphorus, a versatile and effective element for use in flame retardants, has the potential to supersede the halogenated variants that are still widely used today: current formulations employ a variety of modes of action and methods of implementation, as additives or as reactants, to solve the task of developing flameretarding polymeric materials. Phosphorus-based flame retardants can act in both the gas and condensed phase during a fire. This Review investigates how current phosphorus chemistry helps in reducing the flammability of polymers, and addresses the future of sustainable, efficient, and safe phosphorus-based flame-retardants from renewable sources. KW - Flame retardant KW - Phosphorus KW - Halogen-free PY - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:b43-457009 SN - 1433-7851 SN - 1521-3773 VL - 57 IS - 33 SP - 10450 EP - 10467 PB - Wiley VHC AN - OPUS4-45700 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -