TY - JOUR A1 - Bavendiek, K. A1 - Heike, U. A1 - Kosanetzky, J.M. A1 - Ewert, Uwe A1 - Zscherpel, Uwe T1 - Best energy selection for different applications with digital detector arrays from 20 to 600 keV KW - ZfP KW - Radiographie KW - Bildqualität KW - Digitale Detektoren PY - 2012 SN - 0025-5327 VL - 70 IS - 8 SP - 965 EP - 974 PB - Society for Nondestructive Testing CY - Columbus, Ohio AN - OPUS4-26700 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Yang, Q.-C. A1 - Jochum, K.P. A1 - Stoll, B. A1 - Weis, U. A1 - Kuzmin, D. A1 - Wiedenbeck, M. A1 - Traub, Heike A1 - Andreae, M. O. T1 - BAM-S005 type A and B: new silicate reference glasses for microanalysis N2 - To test whether the silicate reference glasses BAM-S005-A and BAM-S005-B from BAM (The Federal Institute for Materials Research and Testing, Germany) are suitable materials for microanalysis, we investigated the homogeneity of these reference glasses using the microanalytical techniques EPMA, LA-ICP-MS and SIMS. Our study indicated that all major and most trace elements are homogeneously distributed at micrometre sampling scale in both types of glass. However, some trace elements (e.g., Cs, Cl, Cr, Mo and Ni) seem to be inhomogeneously distributed. We also determined the composition of BAM-S005-A and BAM-S005-B. The EPMA data of major elements confirmed the information values specified by the certificate. With the exception of Sr, Ba, Ce and Pb, our trace element data by LA-ICP-MS were also in agreement with the certified values within the stated uncertainty limits. The reasons for the discrepancy in these four elements are still unclear. In addition, we report new data for twenty-two further trace elements, for which the concentrations were not certified. Based on our investigation, we suggest that both of these materials are suitable for many microanalytical applications. KW - BAM-S005 KW - Microanalysis KW - Reference glasses KW - Homogeneity KW - Characterisation KW - Laser ablation ICP-MS KW - EPMA KW - SIMS KW - Glass KW - Reference material PY - 2012 DO - https://doi.org/10.1111/j.1751-908X.2012.00171.x SN - 1639-4488 SN - 1751-908X VL - 36 IS - 3 SP - 301 EP - 313 PB - Blackwell CY - Oxford AN - OPUS4-26563 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - RPRT A1 - Traub, Heike A1 - Koch, Matthias A1 - Lück, Detlef A1 - Win, Tin A1 - Lehnik-Habrink, Petra A1 - Schultze, Karin A1 - Saring, U. A1 - Plagemann, R. T1 - Evaluierung von Verfahren für die Untersuchung von Böden nach § 8 Bundes-Bodenschutzgesetz (BBodSchG) (Forschungsbericht 299 71 224 / UBA-FB 000303) N2 - Evaluation of methods for the analysis of soils according to § 8 of the German Federal Soil Protection Act (BBodSchG) The German Federal Soil Protection Act establishes the conditions for effective soil protection and remediation of contaminated sites. In the German Federal Soil Protection and Contaminated Sites Ordinance (BBodSchV) limiting values and methods for the determination of environmentally harmful substances in soils are fixed. The aim of this project was to evaluate selected methods by comparative investigations and proficiency testing schemes. New methods for the determination of inorganic and organic pollutants should be developed and compared with the existing standard methods. Despite the widespread use of ICP-OES up to now no national or international standard is available for the determination of heavy metals in soil extracts with this analytical method. The influence of spectral and non spectral interferences on the accuracy of the results was systematically investigated, especially based on aqua regia soil extracts. Analyte concentration equivalents were determined, too. Based on these results a proposal for a standard was submitted to the corresponding working group of ISO TC 190.[...] KW - Evaluierung von Analyseverfahren KW - ICP-OES KW - Chrom(VI) KW - Cyanide KW - Säulenelution KW - Bodenluft KW - Vor-Ort-Analytik KW - PAK KW - OCP KW - PCB KW - PCP KW - Referenzmaterialien KW - Messunsicherheit PY - 2002 UR - http://www.umweltbundesamt.de/publikationen/evaluierung-von-verfahren-fuer-untersuchung-von SN - 1862-4804 SN - 0722-186X IS - 32 SP - 1 EP - 339 PB - Umweltbundesamt CY - Dessau-Roßlau AN - OPUS4-1760 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Kader, A. A1 - Brangsch, J. A1 - Reimann, C. A1 - Kaufmann, Jan Ole A1 - Mangarova, D. B. A1 - Moeckel, J. A1 - Adams, L. C. A1 - Zhao, J. A1 - Saatz, Jessica A1 - Traub, Heike A1 - Buchholz, R. A1 - Karst, U. A1 - Hamm, B. A1 - Makowski, M. R. T1 - Visualization and Quantification of the Extracellular Matrix in Prostate Cancer Using an Elastin Specific Molecular Probe N2 - One of the most commonly diagnosed cancers in men is prostate cancer (PCa). Understanding tumor progression can help diagnose and treat the disease at an early stage. Components of the extracellular matrix (ECM) play a key role in the development and progression of PCa. Elastin is an essential component of the ECM and constantly changes during tumor development. This article visualizes and quantifies elastin in magnetic resonance imaging (MRI) using a small molecule probe. Results were correlated with histological examinations. Using an elastin-specific molecular probe, we were able to make predictions about the cellular structure in relation to elastin and thus draw conclusions about the size of the tumor, with smaller tumors having a higher elastin content than larger tumors. Human prostate cancer (PCa) is a type of malignancy and one of the most frequently diagnosed cancers in men. Elastin is an important component of the extracellular matrix and is involved in the structure and organization of prostate tissue. The present study examined prostate cancer in a xenograft mouse model using an elastin-specific molecular probe for magnetic resonance molecular imaging. Two different tumor sizes (500 mm3 and 1000 mm3) were compared and analyzed by MRI in vivo and histologically and analytically ex vivo. The T1-weighted sequence was used in a clinical 3-T scanner to calculate the relative contrast enhancement before and after probe administration. Our results show that the use of an elastin-specific probe enables better discrimination between tumors and surrounding healthy tissue. Furthermore, specific binding of the probe to elastin fibers was confirmed by histological examination and laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS). Smaller tumors showed significantly higher signal intensity (p > 0.001), which correlates with the higher proportion of elastin fibers in the histological evaluation than in larger tumors. A strong correlation was seen between relative enhancement (RE) and Elastica–van Gieson staining (R2 = 0.88). RE was related to inductively coupled plasma–mass spectrometry data for Gd and showed a correlation (R2 = 0.78). Thus, molecular MRI could become a novel quantitative tool for the early evaluation and detection of PCa. KW - Magnetic resonance imaging KW - MRI KW - Molecular imaging KW - Cancer KW - LA-ICP-MS PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-538410 DO - https://doi.org/10.3390/biology10111217 VL - 10 IS - 11 SP - 1 EP - 14 PB - MDPI CY - Basel AN - OPUS4-53841 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Kader, A. A1 - Kaufmann, Jan Ole A1 - Mangarova, D. B. A1 - Moeckel, J. A1 - Brangsch, J. A1 - Adams, L. C. A1 - Zhao, J. A1 - Reimann, C. A1 - Saatz, Jessica A1 - Traub, Heike A1 - Buchholz, R. A1 - Karst, U. A1 - Hamm, B. A1 - Makowski, M. R. T1 - Iron Oxide Nanoparticles for Visualization of Prostate Cancer in MRI N2 - Prostate cancer (PCa) is one of the most common cancers in men. For detection and diagnosis of PCa, non-invasive methods, including magnetic resonance imaging (MRI), can reduce the risk potential of surgical intervention. To explore the molecular characteristics of the tumor, we investigated the applicability of ferumoxytol in PCa in a xenograft mouse model in two different tumor volumes, 500 mm3 and 1000 mm3. Macrophages play a key role in tumor progression, and they are able to internalize iron-oxide particles, such as ferumoxytol. When evaluating T2*-weighted sequences on MRI, a significant decrease of signal intensity between pre- and post-contrast images for each tumor volume (n = 14; p < 0.001) was measured. We, furthermore, observed a higher signal loss for a tumor volume of 500 mm3 than for 1000 mm3. These findings were confirmed by histological examinations and laser ablation inductively coupled plasma-mass spectrometry. The 500 mm3 tumors had 1.5% iron content (n = 14; sigma = 1.1), while the 1000 mm3 tumors contained only 0.4% iron (n = 14; sigma = 0.2). In vivo MRI data demonstrated a correlation with the ex vivo data (R2 = 0.75). The results of elemental analysis by inductively coupled plasma-mass spectrometry correlated strongly with the MRI data (R2 = 0.83) (n = 4). Due to its long retention time in the blood, biodegradability, and low toxicity to patients, ferumoxytol has great potential as a contrast agent for visualization PCa. KW - Imaging KW - Nanoparticle KW - Cancer KW - Iron oxide KW - ICP-MS KW - Magnetic resonance imaging PY - 2022 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-550075 DO - https://doi.org/10.3390/cancers14122909 VL - 14 IS - 12 SP - 1 EP - 13 PB - MDPI CY - Basel, Switzerland AN - OPUS4-55007 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -