TY - JOUR A1 - Wieczorek, S. A1 - Schwaar, Timm A1 - Senge, M. O. A1 - Börner, H.G. T1 - Specific drug formulation additives: Revealing the impact of architecture and block length ratio N2 - Combining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG–peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles of difficult small molecule drugs. The tailored peptide segments provide sequence-specific, noncovalent drug binding, and the hydrophilic PEG block renders the complexes water soluble. On the basis of a peptide sequence known to bind the photosensitizer m-tetra(hydroxyphenyl)chlorin (m-THPC) for photodynamic cancer therapy, a set of different conjugate architectures is synthesized and studied. Variations in PEG block length and amplification of the peptidic binding domain of PEG–peptide conjugates are used to fine tune critical parameters for hosting m-THPC, such as drug payload capacities, aggregation sizes, and drug release and activation kinetics. PY - 2015 DO - https://doi.org/10.1021/acs.biomac.5b00961 SN - 1525-7797 VL - 16 IS - 10 SP - 3308 EP - 3312 PB - ACS Publ. CY - Washington, DC, USA AN - OPUS4-35037 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Stutz, C. A1 - Bilecka, I. A1 - Thünemann, Andreas A1 - Niederberger, M. A1 - Börner, H.G. T1 - Superparamagnetic core-shell nanoparticles as solid supports for peptide synthesis N2 - Functional superparamagnetic core–shell nanoparticles are synthesized by a microwave assisted route and can be used as colloidal supports for peptide synthesis in 'quasi solution'. KW - Nanotechnology KW - Small-angle X-ray scatering KW - SAXS PY - 2012 DO - https://doi.org/10.1039/c2cc33492e SN - 0022-4936 SN - 0009-241x SN - 1359-7345 SN - 1364-548x VL - 48 IS - 57 SP - 7176 EP - 7178 PB - Royal Society of Chemistry CY - Cambridge AN - OPUS4-26116 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Choi, Ching-Yi A1 - Lossada, F. A1 - Walter, K. A1 - Fleck-Kunde, T. A1 - Behrens, S. A1 - Meinelt, T. A1 - Falkenhagen, Jana A1 - Hiller, M. A1 - Oschkinat, H. A1 - Dallmann, A. A1 - Taden, A. A1 - Börner, H.G. T1 - Organic transformation of lignin into mussel-inspired glues: next-generation 2K adhesive for setting corals under saltwater N2 - The 2-methoxyphenol units (G-units) in lignin are modified by demethylation and oxidation to provide the activated lignin as one part of an advanced biobased two-component (2K) adhesive system, which exhibits promising shear strengths in dry and underwater applications. The activation of lignin is straightforward and generates quinones via demethylation and periodate oxidation. These act as Michael acceptors and react smoothly with multi-thiol-star polymers to yield thiol-catechol connectivities (TCCs). The mussel-inspired material platform acts as a very robust and versatile adhesive, combining low-cost and readily available lignin with multi-thiols to achieve outstanding adhesion strengths of up to 15 MPa in dry application. In particular, the 2K system is compatible with the marine biological environment and shows no acute toxicity to sensitive organisms such as fish eggs. Thus, one possible application of this material could be an adhesive for setting temperature-resistant corals in damaged reefs. KW - Lignin modification KW - Mussel-inspired adhesive systems PY - 2023 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-594588 DO - https://doi.org/10.1039/d3gc03680d SN - 1463-9270 SP - 1 EP - 15 PB - RSC CY - Cambridge AN - OPUS4-59458 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -