TY - GEN A1 - Gunella, F. A1 - Kunisch, E. A1 - Maenz, S. A1 - Horbert, V. A1 - Xin, L. A1 - Mika, J. A1 - Borowski, J. A1 - Bischoff, S. A1 - Schubert, H. A1 - Sachse, A. A1 - Illerhaus, Bernhard A1 - Günster, Jens A1 - Bossert, J. A1 - Jandt, K. D. A1 - Plöger, F. A1 - Kinne, R. W. A1 - Brinkmann, O. A1 - Bungartz, M. ED - Carragee, T1 - The GDF5 mutant BB-1 enhances the bone formation induced by an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia N2 - BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic Proteins (eg, GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty and kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and to support complete bone regeneration. The biologically optimized GDF5 Mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming CPC containing low-dose BB-1 in a sheep lumbar osteopenia model. STUDY DESIGN/ SETTING: This is a prospective experimental animal study. METHODS: Bone defects (diameter 5 mm) were generated in aged, osteopenic female sheep and were filled with fiber-reinforced CPC alone (L4; CPC+fibers) or with CPC containing different dosages. KW - Bone morphogenetic protein; KW - Bone regeneration; KW - Micro-Computed-Tomography; KW - Calcium phosphate cement; KW - GDF-5 mutant; KW - Large animal model sheep; KW - Osteoporotic vertebral fracture PY - 2018 DO - https://doi.org/10.1016/j.spinee.2017.10.002 SN - 1529-9430 SN - 1878-1632 VL - 18 IS - 2 SP - 357 EP - 369 PB - Elsevier CY - New York AN - OPUS4-44561 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gunella, F. A1 - Kunisch, E. A1 - Bungartz, M. A1 - Maenz, S. A1 - Horbert, V. A1 - Xin, L. A1 - Mika, J. A1 - Borowski, J. A1 - Bischoff, S. A1 - Schubert, H. A1 - Hortschansky, P. A1 - Sachse, A. A1 - Illerhaus, Bernhard A1 - Günster, Jens A1 - Bossert, J. A1 - Jandt, K. D. A1 - Plöger, F. A1 - Kinne, R. W. A1 - Brinkmann, O. T1 - Low-dose BMP-2 is sufficient to enhance the bone formation induced by an injectable, PLGA fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia N2 - BACKGROUND CONTEXT: Bioresorbable calcium phosphate cement (CPC) may be suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures. However, additional targeted de- livery of osteoinductive bone morphogenetic Proteins (BMPs) in the CPC may be required to counteract the augmented local bone catabolism and support complete bone regeneration. PURPOSE: This study aimed at testing an injectable, poly (l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement (CPC) containing low-dose bone morphogenetic Protein BMP-2 in a sheep lumbar osteopenia model. STUDY DESIGN/ SETTING: This is a prospective experimental animal study. METHODS: Bone defects (diameter 5 mm) were generated in aged, osteopenic female sheep and filled with fiber-reinforced CPC alone (L4; CPC+ fibers) or with CPC containing different dosages of BMP-2 (L5; CPC+ fibers + BMP-2; 1, 5, 100, and 500g BMP-2; n=5 or 6 each). The results were compared with those of untouched controls (L1). Three and 9 months after the operation, structural and functional effects of the CPC (±BMP-2) were analyzed ex vivo by measuring (1) bone Mineral density (BMD); (2) bone structure, that is, bone volume/total volume (assessed by micro-computed tomography [micro-CT] and histomorphometry), trabecular thickness, and trabecular number; (3) bone formation, that is, osteoid volume/bone volume, osteoid surface/bone surface, osteoid thickness, mineralizing surface/bone surface, mineral Apposition rate, and bone formation rate/bone surface; (4) bone resorption, that is, eroded surface/bone surface; and (5) compressive strength. RESULTS: Compared with untouched controls (L1), CPC+ fibers (L4) and/or CPC+ fibers + BMP-2(L5) significantly improved all parameters of bone formation, bone resorption, and bone structure. These effects were observed at 3 and 9 months, but were less pronounced for some parameters at 9 months. Compared with CPC without BMP-2, additional significant effects of BMP-2 were demonstrated for bone structure (bone volume/total volume, trabecular thickness, trabecular number) and formation (osteoid surface/bone surface and mineralizing surface/bone surface), as well as for the compressive strength. The BMP-2 effects on bone Formation at 3 and 9 months were dose-dependent, with 5–100g as the optimal dosage. CONCLUSIONS: BMP-2 significantly enhanced the bone formation induced by a PLGA fiber-reinforced CPC in sheep lumbar osteopenia. A single local dose as low as ≤100g BMP-2 was sufficient to augment middle to long-term bone formation. The novel CPC+ BMP-2 may thus represent an alternative to the bioinert, supraphysiologically stiff polymethylmethacrylate cement presently used to treat osteoporotic vertebral fractures by vertebroplasty/kyphoplasty. KW - Bone regeneration KW - Computed tomography KW - Calcium phosphat cement KW - Large animal model sheep KW - Osteoporotic vertebral fracture PY - 2017 DO - https://doi.org/10.1016/j.spinee.2017.06.005 SN - 1529-9430 SN - 1878-1632 VL - 17 IS - 11 SP - 1699 EP - 1711 PB - Elsevier Inc. AN - OPUS4-43237 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bungartz, M. A1 - Kunisch, E. A1 - Maenz, S. A1 - Horbert, V. A1 - Xin, L. A1 - Gunella, F. A1 - Mika, J. A1 - Borowski, J. A1 - Bischoff, S. A1 - Schubert, H. A1 - Sachse, A. A1 - Illerhaus, Bernhard A1 - Günster, Jens A1 - Bossert, J. A1 - Jandt, K. D. A1 - Plöger, F. A1 - Kinne, R. W. A1 - Brinkmann, O. T1 - GDF5 significantly augments the bone formation induced by an injectable, PLGA fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia N2 - BACKGROUND CONTEXT: Biodegradable calcium phosphate cement (CPC) represents a promising option for the surgical treatment of osteoporotic vertebral fractures. Because of augmented local bone catabolism, however, additional targeted delivery of bone morphogenetic proteins with the CPC may be needed to promote rapid and complete bone regeneration. PURPOSE: In the present study, an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement (CPC) containing the bone morphogenetic Protein GDF5 was tested in a sheep lumbar osteopenia model. STUDY DESIGN/SETTING: This is a prospective experimental animal study METHODS: Defined bone defects (diameter 5 mm) were placed in aged, osteopenic female sheep. Defects were treated with fiber-reinforced CPC alone (L4; CPC+ fibers) or with CPC containing different dosages of GDF5 (L5; CPC+ fibers + GDF5; 1, 5, 100, and 500g GDF5; n = 5 or 6 each). The results were compared with those of untouched controls (L1). Three and 9 months postoperation, structural and functional effects of the CPC (±GDF5) were assessed ex vivo by measuring (1) bone mineral density (BMD); (2) bone structure, that is, bone volume/total volume (assessed by micro-computed tomography and histomorphometry), trabecular thickness, and trabecular number; (3) bone formation, that is, osteoid volume/bone volume, osteoid surface/bone surface, osteoid thickness, mineralized surface/bone surface, mineral apposition rate, and bone formation rate/bone surface; (4) bone resorption, that is, eroded surface/bone surface; and (5) compressive strength. RESULTS: Compared with untouched controls (L1), both CPC+ fibers (L4) and CPC+ fibers + GDF5 (L5) numerically or significantly improved all parameters of bone formation, bone resorption, and bone structure. These significant effects were observed both at 3 and 9 months, but for some parameters they were less pronounced at 9 months. Compared with CPC without GDF5, additional significant effects of CPC with GDF5 were demonstrated for BMD and parameters of bone formation and structure (bone volume/total volume, trabecular thickness, and trabecular number, as well as mineralized surface/bone surface). The GDF5 effects were dose-dependent (predominantly in the 5–100g range) at 3 and 9 months. CONCLUSIONS: GDF5 significantly enhanced the bone formation induced by a PLGA fiber-reinforced CPC in sheep lumbar osteopenia. The results indicated that a local dose as low as ≤100g GDF5 may be sufficient to augment middle to long-term bone formation. The novel CPC+ GDF5 combination may thus qualify as an alternative to the bioinert, supraphysiologically stiff poly-(methyl methacrylate) cement currently applied for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures. KW - Bone regeneration KW - Computed tomography KW - Large animal model sheep KW - Osteoporotic vertebral fracture PY - 2017 DO - https://doi.org/10.1016/j.spinee.2017.06.007 SN - 1529-9430 SN - 1878-1632 VL - 17 IS - 11 SP - 1685 EP - 1698 PB - Elsevier Inc. AN - OPUS4-43239 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Lausch, Regine A1 - Wiggenhauser, Herbert A1 - Schubert, F. T1 - Geometrieeffekte und Hüllrohrortung bei der Impaktecho-Prüfung von Betonbauteilen - Experimentelle und modelltheoretische Ergebnisse N2 - Zusammenfassung Bei der Errichtung von Spannbetonbauwerken und der Verwendung immer leistungsfähigerer Betone werden die Anforderungen an eine hochwertige und fehlerlose Bauausführung stetig höher. Zur Vermeidung von Baumängeln und damit zur Sicherung der Tragfähigkeit, sowie zur Erhöhung der Lebensdauer eines Bauwerks ist eine Qualitätsüberwachung bzw. - kontrolle notwendig. Die Hüllrohrortung und die Bestimmung des Verpresszustandes ist demzufolge eine Aufgabe, der im Bauwesen eine wachsende Bedeutung zukommt. An einem Betonprobekörper mit drei Hüllrohren mit unterschiedlichen Verpresszuständen wurden Messungen durchgeführt, mit dem Ziel, diese zu orten und Aussagen über den Verfüllzustand zu machen. Die Position der Hüllrohre im Betonprobekörper konnte eindeutig bestimmt werden. Es war nicht möglich, die Tiefenlage zu ermitteln. Nach der Einbringung und Verpressung eines Stabstahles in eines der Hüllrohre waren signifikante Veränderungen im Impaktechogramm zu erkennen, so dass die beiden Verfüllzustande voneinander zu unterscheiden waren. Gerade bei begrenzter Probekörpergeometrie ist zu beobachten, dass die Impaktechogramme mit regelmäßigen Mustern überlagert werden (Geometrieeffekte). Diese werden hauptsächlich durch die an den seitlichen Bauteilbegrenzungen reflektierten Wellenanteile ausgelöst, erkennbar in den EFIT-Simulationen, welche qualitativ sehr gut mit den experimentellen Befunden übereinstimmen. T2 - Jahrestagung Zerstörungsfreie Materialprüfung 2002 CY - Weimar, Deutschland DA - 2002-05-06 KW - Impaktecho KW - FOR384 KW - Geometrieeffekte KW - Numerische Simulation KW - Hüllrohr PY - 2002 UR - http://www.ndt.net/article/dgzfp02/papers/p34/p34.htm SN - 3-931381-39-0 N1 - Serientitel: Berichtsband / Deutsche Gesellschaft für zerstörungsfreie Prüfung e. V. – Series title: Berichtsband / Deutsche Gesellschaft für zerstörungsfreie Prüfung e. V. IS - 80-CD PB - DGZfP CY - Berlin AN - OPUS4-2214 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Köhler, B. A1 - Schubert, F. A1 - Algernon, Daniel A1 - Gardei, André A1 - Mielentz, Frank A1 - Krause, Martin ED - Thompson, D. O. T1 - Experimental study of elastic waves in concrete for NDE in civil engineering N2 - Laser vibrometric contactless sound field measurements at a concrete test block are presented. Both excitation by an ultrasonic probe and by an impactor were used. The wave modes can be identified by their geometric wave forms and propagation velocities. Additionally, numerical simulation of the experimental situation is used to support this interpretation. Possible applications of the presented technique are discussed. ©2005 American Institute of Physics T2 - 31th Annual Review of Progress in Quantitative Nondestructive Evaluation CY - Golden, CO, USA DA - 2004-07-25 KW - Ultraschall KW - Impact-Echo KW - Wellenausbreitung KW - Visualisierung KW - Modellierung PY - 2005 SN - 0-7354-0245-0 DO - https://doi.org/10.1063/1.1916840 SN - 0743-0760 SN - 0094-243X N1 - Serientitel: AIP conference proceedings – Series title: AIP conference proceedings IS - 760 SP - 1439 EP - 1445 PB - American Institute of Physics CY - Melville, NY AN - OPUS4-5480 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Eschricht, N. A1 - Hoinkis, E. A1 - Mädler, F. A1 - Schubert-Bischoff, P. A1 - Röhl-Kuhn, Barbara T1 - Knowledge-based reconstruction of random porous media N2 - An evolutionary optimization technique is used to reconstruct digitized material models of 3003 nm3 size for mesoporous two-phase systems. The models are adapted to the two-point probability (TPP) and to a volume-based pore-size distribution (PSD) which were derived from SANS and adsorption experiments and which carry statistical information about morphology and topology of the pore system. To avoid extreme update-costs, the bulk of mutations are assessed by means of a suitable approximation of the PSD; it is demonstrated that a sporadic insertion of the PSD suffices to drive the algorithm towards satisfactory models in acceptable time. Our approach is knowledge-based in the sense that (i) the mutations are restricted to expedient exchanges of phase-voxels by a heuristic rule, and (ii) the sporadic calculation of the PSD from the current state of the model, in essence, provides an efficient self-control for the evolutionary process. We applied the method to reconstruct periodic models of the xerogel Gelsil 200. Such reconstructs of real mesoporous solids could be utilized, for instance, to verify theories of adsorption and capillary condensation. KW - Knowledge-based reconstruction KW - Evolutionary optimization KW - SANS KW - Pore size distribution KW - Two-point correlation KW - Porous media KW - Xerogel PY - 2005 DO - https://doi.org/10.1016/j.jcis.2005.05.004 SN - 0021-9797 SN - 1095-7103 VL - 291 IS - 1 SP - 201 EP - 213 PB - Elsevier CY - Orlando, Fla. AN - OPUS4-12522 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Schubert, F. A1 - Wiggenhauser, Herbert A1 - Lausch, Regine T1 - On the accuracy of thickness measurements in impact-echo testing of finite concrete specimens - numerical and experimental results N2 - In impact-echo testing of finite concrete structures, reflections of Rayleigh and body waves from lateral boundaries significantly affect time-domain signals and spectra. In the present paper we demonstrate by numerical simulations and experimental measurements at a concrete specimen that these reflections can lead to systematic errors in thickness determination. These effects depend not only on the dimensions of the specimen, but also on the location of the actual measuring point and on the duration of the detected time-domain signal. KW - Impact-echo testing KW - Concrete KW - Thickness measurements KW - Time-domain simulations PY - 2004 DO - https://doi.org/10.1016/j.ultras.2004.01.076 SN - 0041-624x VL - 42 IS - 1-9 SP - 897 EP - 901 PB - Elsevier CY - Amsterdam AN - OPUS4-11050 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Algernon, Daniel A1 - Gräfe, Boris A1 - Mielentz, Frank A1 - Köhler, B. A1 - Schubert, F. T1 - Imaging of the Elastic Wave Propagation in Concrete Using Scanning Techniques: Application for Impact-Echo and Ultrasonic Echo Methods N2 - Acoustic NDT methods like ultrasonic echo and impact-echo are successfully used for NDT of concrete structures. This paper describes useful techniques for a detailed experimental study of the elastic wave propagation, which is highly relevant for the interpretation of the results obtained from practical measurement applications. By using a scanning laser vibrometer it becomes possible to obtain a 2D visualization of the elastic waves propagating along the surfaces of concrete specimens. Time slices are prepared so that the wave field becomes apparent. In order to visualize especially the surface wave propagation a similar technique using a scanning system with a piezoelectric sensor is applied. The results obtained provide an appropriate basis for the comparison with numerical results from 3-D Elastodynamic finite integration technique (EFIT) calculations, which is demonstrated here. Examples are presented for the application with phased array ultrasonic echo, air-coupled ultrasonic echo and impact-echo. KW - Ultrasonic-echo KW - Impact-echo KW - Laser vibrometer KW - Visualization of wave propagation KW - Elastodynamic finite integration technique (EFIT) PY - 2008 UR - http://www.springerlink.com/content/v739785102l6367x/fulltext.pdf DO - https://doi.org/10.1007/s10921-008-0034-4 SN - 0195-9298 SN - 1573-4862 VL - 27 IS - 1-3 SP - 83 EP - 97 PB - Plenum Press CY - New York, NY AN - OPUS4-18031 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Algernon, Daniel A1 - Schubert, F. A1 - Wiggenhauser, Herbert T1 - Impact-Echo: Experimental and Numerical Study of Acoustic Wave Propagation T2 - NDE Conference on Civil Engineering CY - St. Louis, Missouri, USA DA - 2006-08-14 KW - Impact-Echo KW - Nondestructive Testing KW - Geometry Effects KW - EFIT PY - 2006 SN - 1-57117-148-7 SP - 215 EP - 222 PB - ASTM CY - St. Louis AN - OPUS4-14123 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Algernon, Daniel A1 - Wiggenhauser, Herbert A1 - Schubert, F. T1 - A new approach for the investigation of geometry effects in impact-echo measurements - experimental results and numerical simulations N2 - Impact-Echo (IE) measurements on concrete structures with compact dimensions are influenced by geometry effects, i.e. reflections especially of the surface waves at the boundaries of the test object, which in fact can lead to misinterpretation of the results. In contrast to the normal reflection arrangement, in which the excitation and the measuring sensor are placed on the same side of the specimen, measurements were carried out in a transmission arrangement, where the impactor and the measuring sensor are placed opposite to each other. This serves to reduce the influence of surface waves, and to investigate further their responsibility for the existence of geometry effects. Results obtained from laboratory specimens with smooth surfaces were still seriously affected by geometry effects. Numerical simulations led to the conclusion that surface waves travel around the edges of the specimen, thus creating geometry effects even on the opposite side. Measurements on a specimen, which was cut out from a bridge structure and had irregular connecting planes between the excitation and the measurement side, proved to be remarkably less affected. In order to analyze and visualize the surface wave propagation an arrangement is used, in which the excitation is fixed at a certain point on one plane of the specimen. A transducer scans all planes of the specimen in phase with the excitation. Time slices show the instantaneous wave field on all planes of the specimen. These are compared with numerical simulations. In particular, it can be proved that surface waves indeed travel around the edges of a specimen with smooth connecting planes, thus creating geometry effects even in the transmission arrangement. T2 - 9th European Conference on NDT CY - Berlin, Germany DA - 2006-09-25 KW - Impact-Echo KW - Nondestructive Testing KW - Geometry Effects KW - EFIT PY - 2006 UR - http://www.ndt.net/article/ecndt2006/doc/P19.pdf SN - 3-931381-86-2 SP - 1 EP - 10 PB - European Federation for Non-Destructive Testing CY - Berlin AN - OPUS4-14434 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Große, C. A1 - Wiggenhauser, Herbert A1 - Algernon, Daniel A1 - Schubert, F. A1 - Beutel, R. T1 - Impact-Echo - Stand der Technik und Anwendungen des Verfahrens T2 - DAfStb-Fachtagung 2005 "Zerstörungsfreie Prüfverfahren und Bauwerksdiagnose im Betonbau" CY - Berlin, Deutschland DA - 2005-03-10 PY - 2005 SP - 1 EP - 8 PB - BAM CY - Berlin AN - OPUS4-7366 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gaal, Mate A1 - Bernhardt, Y. A1 - Csaszar, L. A1 - Dengiz, N. A1 - Fuchs, M. A1 - Gautzsch, T. A1 - Gohlke, Dirk A1 - Hahn-Jose, T. A1 - Heckel, Thomas A1 - Hillger, W. A1 - Hufschläger, Daniel A1 - Ilse, D. A1 - Kiel, M. A1 - Labud, P. A1 - Schubert, F. A1 - Sommerhuber, R. A1 - Szewieczek, A. A1 - Waschkies, T. T1 - Richtlinie zur Charakterisierung von luftgekoppelten Ultraschallwandlern N2 - Zur Charakterisierung von luftgekoppelten Ultraschallwandlern werden mehrere verschiedene Methoden und Verfahren angewendet. Durch die unterschiedlichen Herangehensweisen werden oft unterschiedliche Prüfkopfpara-meter und Schallfeldgrößen ermittelt, was einen direkten Vergleich von Datenblättern erschwert. Für die Charakterisierung von Kontakt- und Tauchtechnikprüfköpfen hat sich ISO 22232-2:2021 bereits etabliert, allerdings ist diese Norm nicht auf die luftgekoppelten Wandlertechnologien direkt übertragbar. Daher erkannten Hersteller, Forschungseinrichtungen und Anwender den Bedarf an einer Richtlinie zur einheitlichen Charakterisierung von luftgekoppelten Wandlern. Gemeinsam arbeiten sie aktuell im Rahmen des Unterausschusses „Luftgekoppelte Ultraschallprüfung“ der DGZfP an der Erstellung einer solcher Richtlinie mit dem Anspruch, die bestehende Normung um die luftgekoppelte Prüfung zu erweitern und somit die Vereinheitlichung der Charakterisierung dieser Wandler zu erleichtern. In diesem Beitrag wird ein Überblick über den geplanten Inhalt der Richtlinie und über die Methoden zur akustischen Charakterisierung von luftgekoppelten Ultraschallwandlern gegeben. Insbesondere werden verschiedene Methoden der Ermittlung von wichtigen Wandlerparametern wie z.B. Empfindlichkeit, Mittenfrequenz, Bandbreite, Fokusgröße und Fokusabstand dargestellt und verglichen. T2 - DGZfP-Jahrestagung CY - Kassel, Germany DA - 23.05.2022 KW - Lutgekoppelte Ultraschallprüfung KW - Prüfkopf KW - Charakterisierung KW - Richtlinie PY - 2022 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-552918 SP - 1 EP - 7 AN - OPUS4-55291 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Gaal, Mate A1 - Bernhardt, Y. A1 - Csaszar, L. A1 - Dengiz, N. A1 - Fuchs, M. A1 - Gautzsch, T. A1 - Gohlke, Dirk A1 - Hahn-Jose, T. A1 - Heckel, Thomas A1 - Hillger, W. A1 - Hufschläger, Daniel A1 - Ilse, D. A1 - Kiel, M. A1 - Kornely, M. A1 - Labud, P. A. A1 - Marhenke, T. A1 - Schubert, F. A1 - Sommerhuber, R. A1 - Steinhausen, R. A1 - Szewieczek, A. A1 - Wachter, L. A1 - Waschkies, T. T1 - Guideline US 08 Characterization and verification of air-coupled ultrasonic probes N2 - This guideline was drafted following and complementing the norm ISO 22232-2:2020(E) to include air-coupled ultrasonic transducers. This document specifies the characteristics of probes used for non-destructive air-coupled ultrasonic testing with center frequencies above 20 kHz, with focusing or without focusing means. KW - Air-coupled ultrasound KW - Ultrasonic testing KW - Guideline KW - Probe KW - Characterization PY - 2022 SN - 978-3-947971-26-8 SP - 1 EP - 27 CY - Berlin AN - OPUS4-56228 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bertovic, Marija A1 - Calmon, P. A1 - Carter, L. A1 - Fischer, J. A1 - Forsyth, D. A1 - Holstein, R. A1 - McGrath, B. A1 - Müller, Christina A1 - Pavlovic, Mato A1 - Ronneteg, U. A1 - Rummel, W. A1 - Schubert, F. A1 - Selby, G. T1 - Summary of the "open space technology discussions" on reliability of NDE N2 - Since the beginnings of the European American Workshops (EAW) in 1997, the aim was to gather the experts in NDE reliability and discuss burning topics with the aim of identifying crucial problems and suggesting ways to move forward. This was usually achieved during the so-called break-out sessions, in which predetermined topics were discussed. During the 5th EAW, held in Berlin in 2013, this approach was replaced by an Open Space Technology (OST) approach. The benefit of this approach is seen in the freedom of topic choices, i. e., the topics are not predetermined but rather arise at that moment in that space and by the participants’ choice. The following topics arose: new reliability methods (Bayesian, MAPOD, …), structural health monitoring, definition of requirements of NDE by customer versus provider, what value of POD is good enough?, human factors, manual versus automated inspection, and basic concepts of reliability of NDE. The participants were encouraged to walk from one session to another and openly express their opinions. These were in the end summarized by a chosen group of moderators and presented in this paper. N2 - Seit den Anfängen der europäischen amerikanischen Workshops (EAW) im Jahr 1997 war es das Ziel, Experten auf dem Gebiet der ZfP-Zuverlässigkeit zusammenzuführen und aktuelle Themen zu diskutieren, um wichtige Probleme zu identifizieren und Wege für deren Lösung vorzuschlagen. Dies wurde in der Regel während der sogenannten „Break-out Sessions“ erreicht, in denen vorgegebene Themen diskutiert wurden. Während des 5. EAW, der in Berlin im Jahr 2013 stattfand, wurde dieser Ansatz durch einen Open Space Technology (OST) Ansatz ersetzt. Open Space ist eine Methode der Gruppenmoderation, die sehr gut geeignet ist, um neue Ideen zu entwickeln und selbstständiges Arbeiten zu fördern, d. h. die Themen werden nicht vorgegeben, sondern ergeben sich in diesem Moment in diesem Raum und durch die Wahl der Teilnehmer. Die folgenden Themen wurden herausgearbeitet: neue Zuverlässigkeitsmethoden (Bayes, MAPOD, ...…), Structural Health Monitoring, Definition von Anforderungen der Kunden gegenüber den ZfP-Anbietern, Welcher Wert der POD ist gut genug?, der Einfluss menschlicher Faktoren, manuelle gegenüber automatisierte Prüfung, sowie Grundkonzepte der ZfP-Zuverlässigkeit. Die Teilnehmer wurden aufgefordert, von einer Sitzung zur anderen zu wechseln und offen ihre Meinung zu äußern. Diese Meinungen wurden am Ende von einer ausgewählten Gruppe von Moderatoren zusammengefasst und werden in diesem Beitrag vorgestellt. KW - NDE reliability KW - POD KW - Bayesian approach KW - Structural health monitoring KW - Human factors KW - Open space technology PY - 2014 UR - http://www.hanser-elibrary.com/doi/pdf/10.3139/120.110604 DO - https://doi.org/10.3139/120.110604 SN - 0025-5300 VL - 56 IS - 7-8 SP - 602 EP - 606 PB - Hanser CY - München AN - OPUS4-31269 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertovic, Marija A1 - Calmon, P. A1 - Carter, L. A1 - Fisher, J. A1 - Forsyth, D. A1 - Holstein, R. A1 - McGrath, B. A1 - Müller, Christina A1 - Pavlovic, Mato A1 - Ronneteg, U. A1 - Rummel, W. A1 - Schubert, F. A1 - Selby, G. T1 - Summary of the open space technology discussions T2 - 5th European-American workshop on reliability of NDE CY - Berlin, Germany DA - 2013-10-07 PY - 2013 SN - 978-3-940283-53-5 IS - DGZfP-BB 144 SP - 1 EP - 7(?) CY - Berlin AN - OPUS4-31271 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bungartz, M. A1 - Maenz, S. A1 - Kunisch, E. A1 - Horbert, V. A1 - Xin, L. A1 - Gunella, F. A1 - Mika, J. A1 - Borowski, J. A1 - Bischoff, S. A1 - Schubert, H. A1 - Sachse, A. A1 - Günster, Jens A1 - Illerhaus, Bernhard A1 - Bossert, J. A1 - Jandt, K. D. A1 - Kinne, R. W. A1 - Brinkmann, O. T1 - First-time systematic postoperative clinical assessment of a minimally invasive approach for lumbar ventrolateral vertebroplasty in the large animal model sheep N2 - Large animal models are highly recommended for meaningful preclinical studies, including the optimization of cement augmentation for vertebral body defects by vertebroplasty/kyphoplasty. The aim of this study was to perform a systematic characterization of a strictly minimally invasive in vivo large animal model for lumbar ventrolateral vertebroplasty. This is a prospective experimental animal study. Lumbar defects (diameter 5 mm; depth approximately 14 mm) were created by a ventrolateral percutaneous approach in aged, osteopenic, female sheep (40 Merino sheep; 6–9 years; 68–110 kg). L1 remained untouched, L2 was left with an empty defect, and L3 carried a defect injected with a brushite-forming calcium phosphate cement (CPC). Trauma/functional impairment, surgical techniques (including drill sleeve and working canula with stop), reproducibility, bone defects, cement filling, and functional cement augmentation were documented by intraoperative incision-to-suture time and X-ray, postoperative trauma/impairment scores, and ex vivo osteodensitometry, microcomputed tomography (CT), histology, static/fluorescence histomorphometry, and biomechanical testing. Minimally invasive vertebroplasty resulted in short operation times (28±2 minutes; mean±standard error of the mean) and X-ray exposure (1.59±0.12 minutes), very limited local trauma (score 0.00±0.00 at 24 hours), short postoperative recovery (2.95±0.29 hours), and rapid decrease of the postoperative impairment score to 0 (3.28±0.36 hours). Reproducible defect creation and cement filling were documented by intraoperative X-ray and ex vivo conventional/micro-CT. Vertebral cement augmentation and osteoconductivity of the CPC was verified by osteodensitometry (CPC>control), micro-CT (CPC>control and empty defect), histology/static histomorphometry (CPC>control and empty defect), fluorescence histomorphometry (CPC>control; all p<.05 for 3 and 9 months), and compressive strength measurements (CPC numerically higher than control; 102% for 3 months and 110% for 9 months). This first-time systematic clinical assessment of a minimally invasive, ventrolateral, lumbar vertebroplasty model in aged, osteopenic sheep resulted in short operation times, rapid postoperative recovery, and high experimental reproducibility. This model represents an optimal basis for standardized evaluation of future studies on vertebral augmentation with resorbable and osteoconductive CPC. KW - Computed tomography KW - Calcium phosphate cement KW - Large animal model KW - Minimal-invasive KW - Vertebroplasty KW - Void defect PY - 2016 UR - http://www.sciencedirect.com/science/article/pii/S152994301630273X DO - https://doi.org/10.1016/j.spinee.2016.06.015 VL - 16 IS - 10 SP - 1263 EP - 1275 PB - Elsevier Inc. AN - OPUS4-38429 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Maenz, S. A1 - Brinkmann, O. A1 - Kunisch, E. A1 - Horbert, V. A1 - Gunella, F. A1 - Bischoff, S. A1 - Schubert, H. A1 - Sachse, A. A1 - Xin, L. A1 - Günster, Jens A1 - Illerhaus, Bernhard A1 - Jandt, K. D. A1 - Bossert, J. A1 - Kinne, R. W. A1 - Bungartz, M. T1 - Enhanced bone formation in sheep vertebral bodies after minimally invasive treatment with a novel, PLGA fiber-reinforced brushite cement. N2 - Injectable, brushite-forming calcium phosphate cements (CPC) show potential for bone replacement, but they exhibit low mechanical strength. This study tested a CPC reinforced with poly(l-lactide-co-glycolide) acid (PLGA) fibers in a minimally invasive, sheep lumbar vertebroplasty model. The study aimed to test the in vivo biocompatibility and osteogenic potential of a PLGA fiber-reinforced, brushite-forming CPC in a sheep large animal model. KW - µCT KW - Vertebral KW - PLGA cement PY - 2017 UR - http://www.sciencedirect.com/science/article/pii/S152994301631066X DO - https://doi.org/10.1016/j.spinee.2016.11.006 SN - 1529-9430 SN - 1878-1632 VL - 17 IS - 5 SP - 709 EP - 719 PB - Elsevier Science direct AN - OPUS4-40462 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Fiedler, Georg A1 - Hering, Marcus A1 - Schubert, T. A1 - Bracklow, F. A1 - Nerger, Deborah A1 - Hille, Falk A1 - Beckmann, B. ED - Wuttke, F. ED - Aji, H. ED - Özarmut, A. T1 - Schädigung von Stahlbetonplatten infolge eines harten Anpralls - Vergleich von halb-empirischen Methoden und experimentellen Ergebnissen N2 - Schutzbauwerke von systemkritischen Infrastruktureinrichtungen wie Betonwände und Betonbarrieren müssen Anprallereignissen oder schweren Unfällen in einem vertretbaren Maße widerstehen können. Anprallereignisse können verschiedenster Natur sein. Hierzu zählen Steinschlag, Fahrzeug- oder Flugzeuganprall oder auch Geschosseinschlag. Geschosseinschläge bzw. Bei den Anprall- oder Impaktereignissen wird zwischen hartem und weichem Anprall unterschieden, bei hartem Anprall verformt sich der Anprallkörper nicht oder nur geringfügig, bei weichem Anprall stark. In diesem Artikel werden Forschungsergebnisse zum harten Anprall auf bewehrte Stahlbetonplatten vorgestellt, welche über die letzten Jahre im Rahmen eines Kooperationsprojekts zwischen dem Institut für Massivbau (IMB) der Technischen Universität Dresden (TUD) und der Bundesanstalt für Materialforschung und -prüfung (BAM) durchgeführt wurden. Auf dem Gelände des Otto-Mohr-Labors (OML) der TUD steht hierfür ein speziell konzipierter Fallturm zur Verfügung. Der Aufbau im Fallturm lässt aktuell druckluftbeschleunigte Impaktversuche mit mittleren Anprallgeschwindigkeiten zu. Die durch Anprall geschädigten Stahlbetonplatten wurden anschließend bei der BAM mit Strahlung tomographisch untersucht. Diese Untersuchungen ermöglichen einen Blick auf die Schädigung und Rissstruktur im Inneren der Stahlbetonplatten. Ein Schwerpunkt der durchgeführten Untersuchung ist der Vergleich von Testergebnissen mit den häufig angewendeten halbempirischen Berechnungsmethoden zu den erforderlichen Wandstärken und den sich daraus ergebenden zulässigen Anprallgeschwindigkeiten. Bei diesem Vorgehen wird auch die mit analytischen Methoden abschätzbare Durchdringungsgeschwindigkeit bzw. Austrittgeschwindigkeit eines Projektils ermittelt und mit den realen Testergebnissen verglichen. Außerdem wird der Einfluss von sowohl externen als auch internen Strukturparametern auf Risse betrachtet und ein Fazit abgeleitet. Weiterhin werden laufende und zukünftige wissenschaftliche Untersuchungen zum Anprall auf Betonstrukturen am IMB und der BAM genannt. T2 - 18. D-A-CH-Tagung CY - Kiel, Germany DA - 13.09.2023 KW - Impakt KW - Harter Anprall an Stahlbetonstrukturen KW - Fallturm PY - 2023 SN - 978-3-930108-15-1 SP - 471 EP - 479 PB - Deutsche Gesellschaft für Erdbebeningenieurwesen und Baudynamik (DGEB) e.V. AN - OPUS4-58341 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -