TY - CONF A1 - Climent, Estela A1 - Rurack, Knut A1 - Martinez-Manez, R. T1 - Strip-Based Rapid Tests Containing Gated Mesoporous Materials: A Perfect Combination for Sensitivity Improvement N2 - Rapid tests and assays to be used outside of a laboratory for non-trained personal and also at a point of need are becoming increasingly important in areas such as health, food, security, or the environment. Specially on that regard, paper-based sensors are emerging as a new class of devices because they fulfil the requisites of the "World Health Organization" to be ASSURED: affordable, sensitive, specific, user-friendly, rapid and robust, equipment free and deliverable to end-users. The physical, chemical and mechanical properties of cellulose or glass fiber paper in combination with the facility of preparation are making these materials of great interest while looking for cost-efficient and green alternatives for device production technologies. To improve the sensitivity of these systems, a particularly promising approach is the employment of gated indicator delivery systems using preorganized nanoscopic solid structures incorporated on paper strips to produce an exponential amplification of the detectable signal. Having in mind these concepts, several examples of (bio)gated materials incorporated into sensing membranes will be presented for the detection of small organic molecules, having fluorescence or electrochemiluminescence signal as output signal. Compared with fluorescence, it has been demonstrated that the non-optical excitation has significantly reduced the background signal, and with the help of a portable potentiostat in combination with a home-made 3D-printed case fitted onto a smartphone, the sensitivity of the sensing system has been improved tremendously, from the lower ppb range (fluorescence) to the lower ppt range. With this study, the applicability of ECL detection on paper strips in combination with gated indicator-releasing materials has been demonstrated for the first time, presenting a novel synergistic match. Considering the modularity of the system developed, the platform technology potential is obvious, promising expansion of the general concept to many other analytes, applications and scenarios. T2 - XVI International Workshop on Sensors and Molecular Recognition CY - Valencia, Spain DA - 06.07.2023 KW - Schnelltest KW - Vor-Ort-Analytik KW - Lateral Flow Assays KW - Indikatorfreisetzung KW - Fluoreszenz PY - 2023 AN - OPUS4-57966 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -