TY - JOUR A1 - Anzt, H. A1 - Bach, F. A1 - Druskat, S. A1 - Löffler, F. A1 - Loewe, A. A1 - Renard, B. Y. A1 - Seemann, G. A1 - Struck, A. A1 - Achhammer, E. A1 - Aggarwal, P. A1 - Appel, F. A1 - Bader, M. A1 - Brusch, L. A1 - Busse, C. A1 - Chourdakis, G. A1 - Dabrowski, P. W. A1 - Ebert, P. A1 - Flemisch, B. A1 - Friedl, S. A1 - Fritzsch, B. A1 - Funk, M. D. A1 - Gast, V. A1 - Goth, F. A1 - Grad, J. A1 - Hegewald, J. A1 - Hermann, S. A1 - Hohmann, F. A1 - Janosch, S. A1 - Kutra, D. A1 - Linxweiler, J. A1 - Muth, Thilo A1 - Peters-Kottig, W. A1 - Rack, F. A1 - Raters, F. H. C. A1 - Rave, S. A1 - Reina, G. A1 - Reißig, M. A1 - Ropinski, T. A1 - Schaarschmidt, J. A1 - Seibold, H. A1 - Thiele, J. P. A1 - Uekermann, B. A1 - Unger, S. A1 - Weeber, R. T1 - An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action N2 - Research software has become a central asset in academic research. It optimizes existing and enables new research methods, implements and embeds research knowledge, and constitutes an essential research product in itself. Research software must be sustainable in order to understand, replicate, reproduce, and build upon existing research or conduct new research effectively. In other words, software must be available, discoverable, usable, and adaptable to new needs, both now and in the future. Research software therefore requires an environment that supports sustainability. Hence, a change is needed in the way research software development and maintenance are currently motivated, incentivized, funded, structurally and infrastructurally supported, and legally treated. Failing to do so will threaten the quality and validity of research. In this paper, we identify challenges for research software sustainability in Germany and beyond, in terms of motivation, selection, research software engineering personnel, funding, infrastructure, and legal aspects. Besides researchers, we specifically address political and academic decision-makers to increase awareness of the importance and needs of sustainable research software practices. In particular, we recommend strategies and measures to create an environment for sustainable research software, with the ultimate goal to ensure that software-driven research is valid, reproducible and sustainable, and that software is recognized as a first class citizen in research. This paper is the outcome of two workshops run in Germany in 2019, at deRSE19 - the first International Conference of Research Software Engineers in Germany - and a dedicated DFG-supported follow-up workshop in Berlin. KW - Research Software KW - Sustainable Software Development KW - Academic Software KW - Software Infrastructure KW - Software Training KW - Software Licensing PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-522029 DO - https://doi.org/10.12688/f1000research.23224.2 VL - 9 SP - 1 EP - 35 AN - OPUS4-52202 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Makris, Ruben A1 - Hille, Falk A1 - Thiele, Marc A1 - Kirschberger, D. A1 - Sowietzki, D. T1 - Crack luminescence as an innovative method for detection of fatigue damage N2 - In structural parts under vibrational loading fatigue cracks can initiate and grow, which can lead to structural failure. Conventional non-destructive testing methods for crack detection provide just a snapshot of fatigue crack evolution, whereas crack luminescence coating realizes clear visibility of the entire crack formation. Fatigue causing cyclic tensile tests and examinations on special test bodies allowing control of the crack opening width demonstrate a high sensitivity of the coating. KW - Fatigue damage KW - Crack KW - Luminescence KW - Detection PY - 2018 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-446693 DO - https://doi.org/10.5194/jsss-7-259-2018 SN - 2194-8771 SN - 2194-878X VL - 7 SP - 259 EP - 266 PB - Copernicus Publications CY - Göttingen, Germany AN - OPUS4-44669 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Tamberg, D. A1 - Thiele, D. A1 - Brodda, B. G. A1 - Lammertz, H. A1 - Coerdt, W. A1 - Mainka, E. A1 - Görgenyi, T. A1 - Stütz, A. A1 - Aigner, H. A1 - Deron, S. A1 - Kuhn, E. T1 - Evaluation of an interlaboratory comparison of the chemical assay of U, Th oxide coated particles PY - 1981 SN - 92-0-179081-3 N1 - Serientitel: IAEA safeguards – Series title: IAEA safeguards IS - 3 SP - 1 EP - 38 PB - IAEA CY - Wien AN - OPUS4-33362 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Thiele, D. A1 - Brodda, B.-G. A1 - Mainka, E. A1 - Görgenyi, T. A1 - Kuhn, E. A1 - Aigner, H. T1 - International Comparison of the Chemical Assay of Uranium and Thorium in THTR Fuel for Safegurards Purposes N2 - The Thorium High Temperature Prototype Reactor (THTR) at Schmehausen (Fed. Rep. Germany) burns a (Th, U)O2 nuclear fuel using 93% enriched uranium. This material is particularly safeguards sensitive. An interlaboratory test has been completed on the heavy metal determination in BISO type (Th, U)O2 particles. The laboratories involved were BAM, KFA, KfK, NUKEM and SAL (IAEA). The modified Davies and Gray titration was applied for uranium, oxalate precipitation followed by ignition to ThO2 and gravimetry for thorium. The exercise allowed an estimate to be made of the various error components: the results indicate that the sampling techniques applied in this experiment ensure a representativity of the sample of 0.05% or better. The precision of the measurements (1σ) is better than or equal to 0.15%. Assuming the overall means are the true values, the accuracy of the methods is better than or equal to 0.1%. This fulfills safeguards requirements. PY - 1983 SN - 0022-3115 IS - 113 SP - 142 EP - 148 PB - North Holland Publ. Co CY - Amsterdam AN - OPUS4-40817 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Thiele, D. T1 - Kernbrennstoffanalyse als Grundlage der Kernmaterialüberwachung PY - 1979 SN - 0341-1079 IS - 8 SP - 123 EP - 126 PB - Bundesanstalt für Materialprüfung CY - Berlin AN - OPUS4-9203 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Raddatz, K.-H. A1 - Tamberg, Tomas A1 - Thiele, D. ED - Becker, Gerhard Wilhelm T1 - Kernbrennstoffanalyse in der Bundesanstalt für Materialprüfung (BAM) PY - 1973 SP - 509 EP - 512 PB - Bundesanstalt für Materialprüfung CY - Berlin AN - OPUS4-9690 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Jaeger, Carsten A1 - Ritter, D. A1 - Goeritzer, M. A1 - Thiele, A. A1 - Blumrich, A. A1 - Beyhoff, N. A1 - Luettges, K. A1 - Smeir, E. A1 - Kasch, J. A1 - Grune, J. A1 - Müller, O. A1 - Klopfleisch, R. A1 - Foryst-Ludwig, A. A1 - Kintscher, U. T1 - Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage N2 - Background - It is known that dietary intake of polyunsaturated fatty acids may improve cardiac function. However, relatively high daily doses are required to achieve sufficient cardiac concentrations of beneficial omega‐3 fatty acids. The liver X receptor (LXR) is a nuclear hormone receptor and a crucial regulator of lipid homeostasis in mammals. LXR activation has been shown to endogenously reprogram cellular lipid profiles toward increased polyunsaturated fatty acids levels. Here we studied whether LXR lipid reprogramming occurs in cardiac tissue and exerts cardioprotective actions. Methods and Results - Male 129SV mice were treated with the LXR agonist AZ876 (20 µmol/kg per day) for 11 days. From day 6, the mice were injected with the nonselective β‐agonist isoproterenol for 4 consecutive days to induce diastolic dysfunction and subendocardial fibrosis while maintaining systolic function. Treatment with isoproterenol led to a marked impairment of global longitudinal strain and the E/e' ratio of transmitral flow to mitral annular velocity, which were both significantly improved by the LXR agonist. Histological examination showed a significant reduction in isoproterenol‐induced subendocardial fibrosis by AZ876. Analysis of the cardiac lipid composition by liquid chromatography‐high resolution mass spectrometry revealed a significant increase in cardiac polyunsaturated fatty acids levels and a significant reduction in saturated fatty acids by AZ876. Conclusions - The present study provides evidence that the LXR agonist AZ876 prevents subendocardial damage, improves global longitudinal strain and E/e' in a mouse model of isoproterenol‐induced cardiac damage, accompanied by an upregulation of cardiac polyunsaturated fatty acids levels. Cardiac LXR activation and beneficial endogenous cardiac lipid reprogramming may provide a new therapeutic strategy in cardiac disease with diastolic dysfunction. KW - Heart failure KW - Lipids KW - Liver X receptor KW - Diastolic dysfunction KW - Nuclear receptor PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-529352 DO - https://doi.org/10.1161/JAHA.120.019473 VL - 10 IS - 14 SP - e019473 AN - OPUS4-52935 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -