TY - CONF A1 - Müller, Christina A1 - Rosenthal, Martina A1 - Gaal, Mate A1 - Guelle, D. A1 - Lewis, A. A1 - Sieber, A. T1 - Proposals for Performance Demonstration and Modular Reliability Assessment for Humanitarian Demining N2 - For safe and reliable demining it is necessary to determine the actual true performance of mine searching equipment in detecting mines. The subject to detect a hidden subject by penetrating physical interaction with the target is similar to that of non-destructive testing where it is looked for hidden cracks etc. in material via waves and rays. The non destructive testing profession is now about 100 years old and developed some procedures to check reliability of testing. Those principles like the performance demonstration where the successful detections are statistically evaluated against false calls rates and their implementation in an industrial standard (ASME section XI appendix VIII) are analysed. A first adoption to demining was accomplished in the prescription for blind trials in the CEN workshop agreement CEN BT 126 CWA07 for test and evaluation of metal detectors. A number of blind trials were accomplished within an ITEP project to learn about the necessary statistical layout of those trials to achieve true, reproducible and repeatable results to give guidance to selection and improvement of metal detectors. The special focus in these investigations was on the influence of the human factor due to the degree of experience of the operators and the infulence of uncooperative soil. The correlation of the results of the physical parameter measurement and the statistical results is analysed in a first attempt. T2 - EUDEM2-SCOT conference on requirements and technologies for the detection, removal and neutralization of landmines and UXO CY - Brussels, Belgium DA - 2003-09-15 PY - 2003 UR - http://www.itep.ws/pdf/Mueller_Eudem2003_1.pdf N1 - Geburtsname von Rosenthal, Martina: Scharmach, M. - Birth name of Rosenthal, Martina: Scharmach, M. VL - 1 SP - 233 EP - 241 AN - OPUS4-2785 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Müller, Christina A1 - Rosenthal, Martina A1 - Gaal, Mate A1 - Guelle, D. A1 - Lewis, A. A1 - Sieber, A. T1 - Performance Demonstration for Humanitarian Demining N2 - Because the demining process is always connected with a danger for human beings, it is necessary to make sure the proper functioning of mine searching equipment in detecting mines. Detecting a hidden target by penetrating physical interaction of rays or waves is similar to non-destructive testing. The non-destructive testing profession developed procedures to check the reliability of testing. These procedures, like the performance demonstration where the successful detections are statistically evaluated against false call rates and their implementation in an industrial standard (ASME section XI appendix VIII) are used as a template. A first adoption to demining was accomplished in the prescription for blind trials in the CEN workshop agreement CWA 14747: 2003 for test and evaluation of metal detectors. Within an ITEP project a number of blind trials were carried out to learn about the necessary statistical basis of those trials to achieve true, reproducible and repeatable results to give guidance for the selection and improvement of metal detectors. The special focus in this first investigation was on the influence of the human factor due to the different degree of experience of the operators and the influence of the soil. PY - 2003 DO - https://doi.org/10.1515/mt-2003-0004 SN - 0025-5300 N1 - Geburtsname von Rosenthal, Martina: Scharmach, M. - Birth name of Rosenthal, Martina: Scharmach, M. VL - 45 IS - 11-12 SP - 504 EP - 512 PB - Carl Hanser Verlag CY - München AN - OPUS4-2786 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gaal, Mate A1 - Müller, Christina A1 - Osterloh, Kurt A1 - Rosenthal, Martina A1 - Ewert, Uwe A1 - Guelle, D. A1 - Lewis, A. T1 - Metal Detector Test Trials in Germany and Croatia - ITEP Project 2.1.1.2 T2 - MATEST 2003 NDT Achievements and Challenges CY - Brijuni-Pula, Croatia DA - 2003-09-28 KW - Demining KW - Metal detectors KW - Reliability tests KW - ROC diagrams KW - Test and evaluation KW - CWA07 PY - 2003 N1 - Geburtsname von Rosenthal, Martina: Scharmach, M. - Birth name of Rosenthal, Martina: Scharmach, M. SP - 1(?) EP - 15(?) AN - OPUS4-2784 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Tscharntke, D. A1 - Boehm, Rainer A1 - Müller, Christina A1 - Ronneteg, U. A1 - Rydén, H. T1 - Ultrasonic Investigations on Copper Canister Welds in Preparation for the Storage of Spent Nuclear Fuel in a Deep Repository T2 - 9th European Conference on NDT CY - Berlin, Germany DA - 2006-09-25 KW - Ultrasonic measurement and modelling KW - Copper canister weld KW - Spent nuclear fuel KW - Encapsulation KW - Deep repository PY - 2006 SN - 3-931381-86-2 SP - 1(?) EP - 7(?) PB - European Federation for Non-Destructive Testing CY - Berlin AN - OPUS4-14056 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Osterloh, Kurt A1 - Müller, Christina A1 - Noske, Reinhard A1 - Böcker, Wolfgang D. G. A1 - Ewert, Uwe T1 - Threat Detection Technologies Covering an Extended Range of Eventualities T2 - 9th European Conference on NDT CY - Berlin, Germany DA - 2006-09-25 KW - Hazardous and toxic gasses and vapours KW - Warfare substances KW - Threats other than explosives KW - Multi-gas sensor KW - Detection technology PY - 2006 SN - 3-931381-86-2 SP - 1(?) EP - 11(?) PB - European Federation for Non-Destructive Testing CY - Berlin AN - OPUS4-14472 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Osterloh, Kurt A1 - Müller, Christina A1 - Noske, Reinhard A1 - Böcker, Wolfgang D. G. A1 - Ewert, Uwe T1 - Materialprüfung und Erkennung von Gefahren für die öffentliche Sicherheit T2 - DGZfP-Jahrestagung 2007 CY - Fürth, Deutschland DA - 2007-05-14 KW - Gefahrstoffe KW - Sicherheit KW - Kontrollen KW - Gefahrstoffnachweis KW - EFNDT Arbeitsgruppe 5 PY - 2007 SN - 978-3-931381-98-1 SP - 1 EP - 11 PB - DGZfP CY - Berlin AN - OPUS4-16074 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Müller, Urs A1 - von Weschpfennig, D. A1 - Malaga, Katarina T1 - Anti-Graffiti-Systeme auf Mauerwerk im Bereich der Bundesfernstraßen N2 - Ingenieurbauten des Bundesfernstraßenbereichs sind aufgrund ihrer Exposition an vielen Stellen besonders betroffen von Graffiti. Graffitischmierer nehmen hierbei keine Rücksicht auf die Art der Substratmaterialien, und besonders poröse Untergründe bereiten Schwierigkeiten bei der Reinigung. Um Baustoffoberflächen besser zu schützen und von Graffiti leichter reinigen zu können, wurden in den vergangen Jahren spezielle Prophylaxesysteme (Anti-Graffiti-Systeme, AGS) entwickelten. Für die Beurteilung der Funktionalität und Verwendbarkeit dieser Anti-Graffiti-Systeme wurden von der Bundesanstalt für Straßenwesen (BASt) eine neue Technische Prüfvorschrift und Technische Lieferbedingungen (TP/TL AGS-Beton) erarbeitet. Die TP/TL AGS-Beton gilt hierbei nur für die Beurteilung von AGS auf Betonuntergründen. In einer Forschungsstudie wurde untersucht, inwieweit die vorhandene Prüfvorschrift für Betonsubstrate auch auf andere Untergründe, z. B. Naturstein oder Klinker, angewendet werden kann. Weiterhin wurde untersucht, welche Faktoren eine Rolle bei der Reinigung von mit AGS behandelten verschiedenen Substraten spielen. KW - Anti-Graffiti-System KW - Mauerwerk KW - Beton KW - Reinigungseigenschaft KW - Graffiti KW - Bundesfernstraßenbereich KW - Bauwerkserhaltung/Sanierung KW - Mauerwerksbau KW - Anti-graffiti system KW - Masonry KW - Concrete KW - Cleaning efficacy KW - Maintenance and Repair KW - Masonry construction KW - Federal Motorway System PY - 2011 DO - https://doi.org/10.1002/bate.201101479 SN - 0932-8351 SN - 1437-0999 SN - 0005-6820 SN - 0341-1052 SN - 0932-6359 VL - 88 IS - 7 SP - 443 EP - 450 PB - Ernst & Sohn CY - Berlin AN - OPUS4-24369 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - RPRT A1 - Gaal, Mate A1 - Bertovic, Marija A1 - Müller, Christina A1 - Zickler, S. A1 - Fahlbruch, B. A1 - Spokoiny, V. A1 - Schombach, D. A1 - Just, Tilman A1 - Cramer, H.-J. T1 - Untersuchungen zum Einfluss menschlicher Faktoren auf das Ergebnis von zerstörungsfreien Prüfungen, Möglichkeiten zur Minimierung dieses Einflusses und Bewertung der Prüfergebnisse KW - Menschliche Faktoren KW - ZfP KW - Manuelle Ultraschallprüfung KW - WkP KW - KKW PY - 2009 IS - BfS-Projekt SR 2514 / Endbericht SP - 1 EP - 79 CY - Salzgitter AN - OPUS4-26081 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertovic, Marija A1 - Fahlbruch, B. A1 - Müller, Christina A1 - Pitkänen, J. A1 - Ronneteg, U. A1 - Gaal, Mate A1 - Kanzler, Daniel A1 - Ewert, Uwe A1 - Schombach, D. T1 - Human factors approach to the acquisition and evaluation of NDT data N2 - This paper gives an introduction to the field of human factors with the focus on their influence on the reliability of NDT in the nuclear energy production (in-service inspections) and final storage of highly radioactive nuclear waste. A set of methodological tools has been developed in the scope of three projects, namely: 1) a theoretical model describing potential human factors influencing manual ultrasonic inspection performance during inservice inspections in nuclear power plants; 2) a method for identifying potential human errors during acquisition and evaluation of data gathered with mechanized ultrasonic, radiographic and eddy-current systems, as well as visual testing with a remote camera (Failure Modes and Effects Analysis, FMEA); and 3) use of eye tracking methodology to optimize existing procedures and practices. The experimental results have shown that time pressure, mental workload and experience influence the quality of the inspection performance. Noticeable were influences from the organization of the working schedule, communication, procedures, supervision and demonstration task. Implementing human redundancy in critical tasks, such as defect identification, as well as using an automated aid (software) to help operators in decision making about the existence and size of defects, could lead to other kinds of problems, namely social loafing (excerpting less effort when working on tasks collectively as compared to working alone) and automation bias (uncritical reliance on the proper function of an automated system without recognizing its limitations and the possibilities of automation failure) that might affect the reliability of NDT in an undesired manner. T2 - 18th WCNDT - World conference on nondestructive testing CY - Durban, South Africa DA - 16.04.2012 KW - Human Factors KW - Time Pressure KW - 4-Eye Principle KW - Automation Bias KW - Nuclear Waste Storage KW - In-Service Inspection (ISI) KW - Nuclear Power Plants KW - Eye Tracking KW - Failure Modes and Effects Analysis (FMEA) PY - 2012 SN - 978-0-620-52872-6 SP - 1 EP - 10 (Paper 198) AN - OPUS4-27583 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Müller, Christina A1 - Rosenthal, Martina A1 - Konchina, V. A1 - Markucic, D. A1 - Piscenec, Z. T1 - General principles of reliability assessment of NDE systems and its applicability to the mine detection practice N2 - The reliability investigations are dedicated to throw light on the performance of the NDE system with respect to the required aim. This is especially of interest when it is looked for life damaging objects in the case of mine seeking and when it is even more difficult to distinguish between the different suppliers of methods concerning their actual capability. In accordance with the conception of EFNDT WG5 and CEN BT 126 CW 07 the authors have the aim to transfer the knowledge in reliability measurement of NDE systems to the reliability measurement of mine detection systems. For this the three basic ways to investigate the reliability of NDE signals will be described. The first way of investigation, the performance demonstration, is preferred e.g. in the US American nuclear power industry. This is an integral consideration of the non destructive test as a system where the whole NDE system is packed in a black box and only the input in terms of the real existing flaws in the component is considered and compared to the output in terms of the indications of the human inspector or of the automated system. The second - the European tradition – relies on a standardized description of physical/technical parameters of the NDE system which are preconditions for successful system performance. The third approach - the modular conception - is a marriage of both: The signal chain is cut into main modules. Each module is assessed in a most appropriate individual way e.g. via modeling calculations. The single results are joint together according to the reliability theory of systems where the reliability of the total system is composed of the reliability of the subsystems. Separating criteria for the system were proposed through a reliability formula developed during a series of European-American workshops on NDE reliability. A further essential parameter especially for demining systems are the repeatability and reproducibility. Their affect on the reliability and its scatter will be investigated. Examples for the ROC/POD approach in terms of the investigation of the reliability of ultrasonic manual testing and for first attempts for the reliability investigation of demining data will be presented. It will be strongly recommended to apply the ROC/POD and Modular Conceptions to the assessment and optimization of mine seeking systems. T2 - 8th ECNDT CY - Barcelona, Spain DA - 2002-06-17 PY - 2002 UR - http://www.ndt.net/article/ecndt02/397/397.htm N1 - Geburtsname von Rosenthal, Martina: Scharmach, M. - Birth name of Rosenthal, Martina: Scharmach, M. PB - European Federation for Non-Destructive Testing CY - Barcelona AN - OPUS4-2015 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Müller, Christina A1 - Rosenthal, Martina A1 - Wilrich, Peter-Th. A1 - Konchina, V. A1 - Markucic, D. A1 - Piscenec, Z. T1 - Proposals for Performance Demonstration and Modular Validation T2 - NDRF Summer Conference 2002 CY - Rosersberg, Sweden DA - 2002-08-28 PY - 2002 N1 - Geburtsname von Rosenthal, Martina: Scharmach, M. - Birth name of Rosenthal, Martina: Scharmach, M. SP - 1(?) EP - 10(?) AN - OPUS4-2017 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Müller-Vahl, H. F. A1 - Strangfeld, Christoph A1 - Nayeri, C. N. A1 - Paschereit, C. O. A1 - Greenblatt, D. T1 - Dynamic Stall Under Combined Pitching and Surging N2 - Dynamic stall often occurs under conditions of simultaneous unsteady pitching and surging (e.g., rotorcraft and wind turbines), butmanymodels employ a dimensionless time base that implicitly assumes that surging is superimposed, in a quasi-steady manner, on dynamic pitching. An unsteady wind tunnel was used to examine this assumption, where a technique was developed to quantify the unsteady effects of surging on a pitching NACA 0018 airfoil. The technique involved performing multiple harmonic pitching experiments under nominally steady freestream conditions that bracketed a corresponding 50% surging amplitude (1.25 ⋅ 105 ≤ Re ≤ 3.75 ⋅ 105). By interpolating these data, unsteady-pitching/quasi-steady-surging data sets were constructed and compared with de facto synchronous pitch and surging experiments, thereby isolating the unsteady effects of surging on a pitching airfoil. Both large and small poststall maximum angles of attack (αs + 5° and αs + 15°) were considered at multiple pitch-surge phase differences. During deep dynamic stall (αs � 15°), with large-scale separation, surging was seen to have a secondary effect on the unsteady aerodynamics. However, at small poststall maximum angles of attack (αs + 5°), either light or deep dynamic stall behavior was observed depending upon the pitch-surge phase difference. This was attributed to Reynolds number history effects, exemplified by boundary-layer transition, and thus it can be referred to as “transitional” dynamic stall. KW - Dynamic stall KW - Angle of attack oscillations KW - Free stream velocity osciallations PY - 2020 DO - https://doi.org/10.2514/1.J059153 VL - 58 IS - 12 SP - 5134 EP - 5145 PB - American Institute of Aeronautics and Astronautics AN - OPUS4-51037 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Weh, Lothar A1 - Müller, Ralf A1 - Moseler, D. A1 - Heide, G. A1 - Frischat, G. T1 - Topographische Untersuchungen von Glasoberflächen mit Vickers-Eindrücken T2 - 74. Glastechnische Tagung CY - Ulm, Deutschland DA - 2000-05-29 PY - 2000 SP - 237 EP - 240 PB - DGG, Dt. Glastechn. Ges. CY - Frankfurt/M. AN - OPUS4-934 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Müller, Ralf A1 - Prado, M. O. A1 - Zanotto, E. D. T1 - Model for sintering polydispersed glass particles N2 - We propose a model to describe the sintering kinetics of polydispersed glass particles, having no adjustable parameter. The model is based on three sintering stages: a pure ‘Frenkel' (F) first step, a mixed ‘Frenkel/Mackenzie–Shuttleworth' stage, and a third, pure ‘Mackenzie–Shuttleworth' (MS) step. The model considers sample shrinkage as the sum of the partial shrinkage of several clusters, each consisting of equally sized particles and each showing independent F or MS behavior. The overall set of clusters mimics the specimen's real particle size distribution. We then introduce the concept of neck forming ability, which allows the formation of necks among particles of different sizes, relaxing the clustering condition. Using experimental physical parameters: particle size distribution, viscosity, surface energy, and the theoretical neck forming ability, the model describes well the sintering kinetics of an alumino-borosilicate glass powder having polydispersed, irregular shaped particles in a variety of temperatures. The sintering kinetics of the real powder is slower, but not far from the calculated kinetics of a monodispersed distribution containing only particles of average size. Thus the model provides a tool for estimating the sintering kinetics of real glass powders, for any size distribution and temperature, thus minimizing the number of laboratory experiments. PY - 2001 DO - https://doi.org/10.1016/S0022-3093(00)00399-9 SN - 0022-3093 VL - 279 IS - 2-3 SP - 169 EP - 178 PB - North-Holland Publ. Co. CY - Amsterdam AN - OPUS4-935 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Strangfeld, Christoph A1 - Müller-Vahl, H. A1 - Nayeri, C. N. A1 - Paschereit, C. O. A1 - Greenblatt, D. T1 - Airfoil in a high amplitude oscillating stream N2 - A combined theoretical and experimental investigation was carried out with the objective of evaluating theoretical predictions relating to a two-dimensional airfoil subjected to high amplitude harmonic oscillation of the free stream at constant angle of attack. Current theoretical approaches were reviewed and extended for the purposes of quantifying the bound, unsteady vortex sheet strength along the airfoil chord. This resulted in a closed form solution that is valid for arbitrary reduced frequencies and amplitudes. In the experiments, the bound, unsteady vortex strength of a symmetric 18 % thick airfoil at low angles of attack was measured in a dedicated unsteady wind tunnel at maximum reduced frequencies of 0.1 and at velocity oscillations less than or equal to 50 %. With the boundary layer tripped near the leading edge and mid-chord, the phase and amplitude variations of the lift coefficient corresponded reasonably well with the theory. Near the maximum lift coefficient overshoot, the data exhibited an additional high-frequency oscillation. Comparisons of the measured and predicted vortex sheet indicated the existence of a recirculation bubble upstream of the trailing edge which sheds into the wake and modifies the Kutta condition. Without boundary layer tripping, a mid-chord bubble is present that strengthens during flow deceleration and its shedding produces a dramatically different effect. Instead of a lift coefficient overshoot, as per the theory, the data exhibit a significant undershoot. This undershoot is also accompanied by high-frequency oscillations that are characterized by the bubble shedding. In summary, the location of bubble and ist subsequent shedding play decisive roles in the resulting temporal aerodynamic loads. KW - vortex shedding KW - aerodynamics KW - general fluid mechanics PY - 2016 DO - https://doi.org/10.1017/jfm.2016.126 SN - 0022-1120 VL - 2016 IS - 793 SP - 79 EP - 108 AN - OPUS4-35594 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Müller, Maike A1 - Gornushkin, Igor B. A1 - Florek, S. A1 - Mory, D. A1 - Panne, Ulrich T1 - Approach to Detection in Laser-Induced Breakdown Spectroscopy N2 - Gated detection with intensified detectors, e.g., ICCDs, is today the accepted approach for detection of plasma emission in laser-induced breakdown spectroscopy (LIBS). However, these systems are more cost-intensive and less robust than nonintensified CCDs. The objective of this paper is to compare, both theoretically and experimentally, the performance of an intensified (ICCD) and nonintensified (CCD) detectors for detection of plasma emission in LIBS. The CCD is used in combination with a mechanical chopper, which blocks the early continuum radiation from the plasma. The detectors are attached sequentially to an echelle spectrometer under the same experimental conditions. The laser plasma is induced on a series of steel samples under atmospheric conditions. Our results indicate that there is no substantial difference in the performance of the CCD and ICCD. Signal-to-noise ratios and limits of detection achieved with the CCD for Si, Ni, Cr, Mo, Cu, and V in steel are comparable or even better than those obtained with the ICCD. This result is further confirmed by simulation of the plasma emission signal and the corresponding response of the detectors in the limit of quantum (photon) noise. KW - LIBS KW - Detektorvergleich KW - ICCD CCD PY - 2007 DO - https://doi.org/10.1021/ac0621470 SN - 0003-2700 SN - 1520-6882 VL - 79 IS - 12 SP - 4419 EP - 4426 PB - American Chemical Society CY - Washington, DC AN - OPUS4-15044 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Jakubowski, Norbert A1 - Müller, L. A1 - Traub, Heike A1 - Esteban-Fernández, D. A1 - Panne, Ulrich A1 - Herrmann, Antje A1 - Schellenberger, E. A1 - Theuring, F. A1 - Kneipp, Janina T1 - Imaging by laser ablation ICP-MS N2 - ICP-MS is a well-established analytical method which excels by high accuracy, high dynamic range and extremely low limits of detection for most metals. Furthermore ICP-MS offers a very high multi-element coverage so that many elements of the periodic table can be detected simultaneously. In this series of lectures, we want to focus on the historical developments, fundamentals, instrumentation and novel applications of ICP-MS in the life and material sciences. T2 - Ringvorlesung Analytik CY - Humboldt-Universität zu Berlin DA - 23.06.2017 KW - Laser ablation ICP-MS KW - Bio-Imaging PY - 2017 AN - OPUS4-40757 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Jaeger, Carsten A1 - Ritter, D. A1 - Goeritzer, M. A1 - Thiele, A. A1 - Blumrich, A. A1 - Beyhoff, N. A1 - Luettges, K. A1 - Smeir, E. A1 - Kasch, J. A1 - Grune, J. A1 - Müller, O. A1 - Klopfleisch, R. A1 - Foryst-Ludwig, A. A1 - Kintscher, U. T1 - Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage N2 - Background - It is known that dietary intake of polyunsaturated fatty acids may improve cardiac function. However, relatively high daily doses are required to achieve sufficient cardiac concentrations of beneficial omega‐3 fatty acids. The liver X receptor (LXR) is a nuclear hormone receptor and a crucial regulator of lipid homeostasis in mammals. LXR activation has been shown to endogenously reprogram cellular lipid profiles toward increased polyunsaturated fatty acids levels. Here we studied whether LXR lipid reprogramming occurs in cardiac tissue and exerts cardioprotective actions. Methods and Results - Male 129SV mice were treated with the LXR agonist AZ876 (20 µmol/kg per day) for 11 days. From day 6, the mice were injected with the nonselective β‐agonist isoproterenol for 4 consecutive days to induce diastolic dysfunction and subendocardial fibrosis while maintaining systolic function. Treatment with isoproterenol led to a marked impairment of global longitudinal strain and the E/e' ratio of transmitral flow to mitral annular velocity, which were both significantly improved by the LXR agonist. Histological examination showed a significant reduction in isoproterenol‐induced subendocardial fibrosis by AZ876. Analysis of the cardiac lipid composition by liquid chromatography‐high resolution mass spectrometry revealed a significant increase in cardiac polyunsaturated fatty acids levels and a significant reduction in saturated fatty acids by AZ876. Conclusions - The present study provides evidence that the LXR agonist AZ876 prevents subendocardial damage, improves global longitudinal strain and E/e' in a mouse model of isoproterenol‐induced cardiac damage, accompanied by an upregulation of cardiac polyunsaturated fatty acids levels. Cardiac LXR activation and beneficial endogenous cardiac lipid reprogramming may provide a new therapeutic strategy in cardiac disease with diastolic dysfunction. KW - Heart failure KW - Lipids KW - Liver X receptor KW - Diastolic dysfunction KW - Nuclear receptor PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-529352 DO - https://doi.org/10.1161/JAHA.120.019473 VL - 10 IS - 14 SP - e019473 AN - OPUS4-52935 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Horn, Wolfgang A1 - Kasche, J. A1 - Jann, Oliver A1 - Müller, D. T1 - Emissions- und Geruchsuntersuchungen an Bauprodukten - Ergebnisse eines UFO-Planprojektes T2 - 8th Workshop "Odour and Emissions of Plastic Materials" CY - Kassel, Germany DA - 2006-03-27 KW - Bauprodukte KW - Emissionen KW - Geruch KW - RAL UZ PY - 2006 SP - 13-1- 13-7 CY - Kassel AN - OPUS4-12259 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - GEN A1 - Kasche, J. A1 - Dahms, A. A1 - Horn, Wolfgang A1 - Jann, Oliver A1 - Müller, D. T1 - Sensory evaluation of building products - Results of a German round robin test T2 - VDI-Tagung CY - Bad Kissingen, Deutschland DA - 2007-11-13 KW - Bauprodukte KW - Emissionen KW - Geruch KW - AbBB-Schema KW - Kammermessungen KW - Blauer Engel PY - 2007 SN - 978-3-18-091995-9 SN - 0083-5560 IS - 1995 SP - 193 EP - 202 PB - VDI-Verl. CY - Düsseldorf AN - OPUS4-16322 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -