TY - JOUR A1 - Müeller, W.-D. A1 - Gross, U. A1 - Fritz, Th. A1 - Voigt, Ch. A1 - Fischer, P. A1 - Berger, Georg A1 - Rogaschewski, S. A1 - Lange, K.-P. T1 - Evaluation of the interface between bone and titanium surfaces being blasted by aluminium oxide or bioceramic particles N2 - The surface structure, in particular the surface roughness, and the surface chemistry of titanium implants influence their anchoring in bone. The aim of this study was to analyse metal-bone contact (MBC) after modification of the implant surface, using different materials for blasting. The surface modification of titanium was produced by blasting it with particles made of Al2O3 or bioceramics. The biological effects were then investigated experimentally using 27 rabbits, analysed after 7, 28 and 84 days after the implantation of titanium cylinders treated accordingly. The MBC showed a tendency for more bone after bioceramics were used as a blasting material, compared to Al2O3. KW - Dental implants KW - Surface modification KW - Animal experiment KW - Bioceramics PY - 2003 DO - https://doi.org/10.1034/j.1600-0501.2003.00791.x SN - 0905-7161 SN - 1600-0501 VL - 14 IS - 3 SP - 349 EP - 356 PB - Blackwell Munksgaard CY - Oxford AN - OPUS4-3506 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Gross, U. A1 - Müller-Mai, C. A1 - Knabe, C. A1 - Berger, Georg A1 - Ploska, Ute A1 - Gildenhaar, Renate ED - Vincenzini, P. T1 - Animal experiments with biomaterials for direct bone contact displaying higher or lower solubility in comparison to TCP and HA products T2 - 10th International Ceramics Congress ; 3rd Forum on New Materials ; 10th CIMTEC 2002 CY - Florence, Italy DA - 2002-07-14 PY - 2004 SP - 369 EP - 376 PB - Techna CY - Faenza AN - OPUS4-3500 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, Ch. A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Klar, F. A1 - Zreiqat, H. T1 - The modulation of osteogenesis in vitro by calcium titanium phosphate coatings N2 - Calcium phosphate coated titanium and titanium alloy are widely used as dental and orthopaedic implants. This study examines the effect of novel calcium titanium and calcium titanium zirconium phosphates suitable for plasma-spraying onto titanium substrata on the expression of bone-related genes and proteins by human bone-derived cells (HBDC) and compares this behavior to that on native titanium and hydroxyapatite-coated titanium. Test materials were an acid etched and sand-blasted titanium surface (Ti-DPS), a plasma-sprayed hydroxyapatite coating (HA), and five materials which were created from CaTi4(PO4)6 (CTP) and CaZr4(PO4)6 (CZP): sintered CaTi4(PO4)6 (CTP-S1), sintered 46CaO·23TiO2·31P2O5 (CTP-S2), sintered CaTiZr3(PO4)6, (CTZP-S1), sintered 46CaO·23ZrO2·31P2O5 (CTZP-S2) and sintered 55CaO·20TiO2·31P2O5 (CTP-S3). HBDC were grown on the substrata for 3, 7, 14 and 21 d, counted and probed for various mRNAs and proteins (type I collagen, osteocalcin, osteopontin, osteonectin, alkaline phosphatase and bone sialoprotein). All substrates significantly affected cellular growth and the temporal expression of an array of bone-related genes and proteins. At 14 and 21 d, cells on CTP-S3 displayed significantly enhanced expression of all osteogenic mRNAs. Surfaces of CTP-S1 and CTP-S3 had the most effect on osteoblastic differentiation inducing a greater expression of an array of osteogenic markers than recorded for cells grown on Ti-DPS and HA, suggesting that these novel materials may possess a higher potency to enhance osteogenesis. KW - Calcium phosphate coatings KW - Osteoblast KW - In vitro test KW - In situ hybridization KW - Osteogenesis PY - 2004 DO - https://doi.org/10.1016/j.biomaterials.2004.01.059 SN - 0142-9612 VL - 25 IS - 20 SP - 4911 EP - 4919 PB - Elsevier CY - Oxford AN - OPUS4-3501 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, C. A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Meyer, J. A1 - Howlett, C. A1 - Markovic, B. A1 - Zreiqat, H. T1 - Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro N2 - The use of biodegradable bone substitutes is advantageous for alveolar ridge augmentation because it avoids second-site surgery for autograft harvesting. This study examines the effect of novel, rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins by human bone-derived cells (HBDCs) and compares this behavior to that of tricalciumphosphate (TCP). Test materials were -TCP, two materials with a crystalline phase Ca2KNa(PO4)2 and with a small amorphous portion containing either magnesium potassium phosphate (material denominated GB14) or silica phosphate (material denominated GB9), and a calcium phosphate bone cement (material denominated Biocement D). HBDCs were grown on the substrata for 3, 7, 14, and 21 days, counted, and probed for various mRNAs and proteins (type I collagen, osteocalcin, osteopontin, osteonectin, alkaline phosphatase, and bone sialoprotein). All substrates supported continuous cellular growth for 21 days. In the presence of GB14 and Biocement D specimens cell proliferation was reduced and cell differentiation increased. At day 21, the greatest number of cells was found on GB9 expressing significantly higher levels of bone-related proteins than cells grown on all other surfaces. Because all novel materials facilitated the expression of the osteoblastic phenotype at least as much as TCP and the polystyrene control, these biomaterials can be regarded as excellent candidate bone substitute materials. GB9 induced the highest proliferation and cellular differentiation after 21 days of incubation, suggesting that this material may possess a higher potency for enhancing osteogenesis than TCP. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 69A: 145-154, 2004 KW - Calcium phosphate ceramics KW - Human bone-derived cells KW - Cell-biomaterial interactions KW - Calcium phosphate cements KW - In situ hybridization PY - 2004 DO - https://doi.org/10.1002/jbm.a.20131 SN - 1549-3296 SN - 1552-4965 VL - 69 IS - 1 SP - 145 EP - 154 PB - Wiley CY - Hoboken, NJ AN - OPUS4-3502 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Harbich, Karl-Wolfram A1 - Mücke, Udo A1 - Berger, Georg T1 - Characterisation of highly porous glass ceramic scaffolds N2 - Schwammartige glaskeramische Biowerkstoffe werden zunehmend als Knochenersatzmaterial verwendet und sind bereits im Tierversuch erprobt. Für den optimalen Einsatz dieser gut resorbierbaren Biowerkstoffe ist eine zuverlässige Charakterisierung erforderlich. Im Vordergrund stehen dabei der Herstellungsprozess, über den die offene Porosität kontrolliert eingestellt wird, sowie der Sintervorgang, der die Struktur des keramischen Gerüstmaterials entscheidend prägt. Hier werden mittels Röntgenrefraktionsanalyse und lichtoptischer Bildauswertung sowohl Porosität als auch die innere Oberflächendichte bestimmt. Während mit beiden Verfahren die Porositäten gut übereinstimmen, weichen die Oberflächendichten signifikant voneinander ab. Dieser Unterschied ist hauptsächlich auf mikrostrukturelle Defekte im keramischen Werkstoffgefüge zurückzuführen, die von der Bildanalyse quantitativ nur unvollständig erfasst werden. Dagegen ist die bildanalytische Auswertung der typischen, großporigen Hohlraumstruktur im Vergleich zur Röntgenrefraktion von Vorteil. Die Untersuchungen zeigen, dass die Kombination beider Verfahren eine geeignete Ergänzung darstellt, um die Strukturparameter verlässlich bestimmen zu können. Dies ist auch die wesentliche Voraussetzung für die Optimierung der Materialeigenschaften. KW - Glaskeramische Biowerkstoffe KW - Innere Oberflächen KW - Porosität KW - Röntgenrefraktionsanalyse KW - Lichtoptische Bildanalyse PY - 2004 DO - https://doi.org/10.3139/120.100585 SN - 0025-5300 VL - 46 IS - 5 SP - 243 EP - 247 PB - Carl Hanser Verlag CY - München AN - OPUS4-3740 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Klaffke, Dieter A1 - Berger, Georg A1 - Hartelt, Manfred T1 - Tribologische Untersuchungen an Ti-6Al-4V mit und ohne Calciumtitanat-Reaktionsschicht KW - Reibung KW - Verschleiß KW - Ti-6Al-4V KW - Calciumtitanat KW - Friction KW - Wear KW - Calcium titanate PY - 2004 SN - 1616-0177 SN - 0011-8656 VL - 5 IS - 2 SP - 67 EP - 70 PB - Verl. Neuer Merkur CY - München AN - OPUS4-3684 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Cool bone cement T2 - 17. Treffpunkt Mmedizintechnik CY - Berlin, Germany DA - 2003-05-22 PY - 2003 AN - OPUS4-4740 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Knabe, Ch. A1 - Berger, Georg A1 - Gildenhaar, Renate A1 - Howlett, C.R. A1 - Markovic, B. A1 - Zreiqat, H. T1 - The functional expression of human bone-derived cells grown on rapidly resorbable calcium phosphate ceramics N2 - The use of biodegradable bone substitutes is advantageous for alveolar ridge augmentation, since it avoids second-site surgery for autograft harvesting. This study examines the effect of novel, rapidly resorbable calcium phosphates on the expression of bone-related genes and proteins by human bone-derived cells (HBDC) and compares this behavior to that of tricalciumphosphate (TCP). Test materials were a-TCP, and four materials which were created from ß-Rhenanite and its derivatives: R1-ß-Rhenanite (CaNaPO4); R1/M2 composed of CaNaPO4 and MgNaPO4; R1+SiO2 composed of CaNaPO4 and 9% SiO2 (wt%); and R17-Ca2KNa(PO4)2. HBDC were grown on the substrata for 3, 5, 7, 14 and 21 days, counted and probed for various mRNAs and proteins (Type I collagen, osteocalcin, osteopontin, osteonectin, alkaline phosphatase and bone sialoprotein). All substrata supported continuous cellular growth for 21 days. At day 21, surfaces of R1+SiO2 and R17 had the highest number of HBDC. At 14 and 21 days, cells on R1 and on R1+SiO2 displayed significantly enhanced expression of all osteogenic proteins. Since all novel calcium phosphates supported cellular proliferation together with expression of bone-related proteins at least as much as TCP, these ceramics can be regarded as potential bone substitutes. R1 and R1+SiO2 had the most effect on osteoblastic differentiation, thus suggesting that these materials may possess a higher potency to enhance osteogenesis than TCP. KW - Calcium phosphate ceramics KW - Human bone-derived cells KW - Cell-biomaterial interactions KW - Bone substitutes KW - In situ hybridization PY - 2004 DO - https://doi.org/10.1016/S0142-9612(03)00525-8 SN - 0142-9612 VL - 25 IS - 2 SP - 335 EP - 344 PB - Elsevier CY - Oxford AN - OPUS4-2957 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Resorbierbaer Knochenersatz auf der Basis alkalihaltiger Calciumphosphate T2 - 2. Workshop "Biokeramik" der Deutschen Mineralogischen Gesellschaft CY - Freiberg, Germany DA - 2003-10-06 PY - 2003 AN - OPUS4-5289 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Resorbierbarer Knochenersatz auf Basis von Calciumphosphaten T2 - Kolloqium der Abt. für Funktionswerkstoffe der Medizin und Zahnheilkunde der Universitätsklinik und Polikliniken für Zahn-, Mund- und Kieferkrankheiten der Bayrischen Maximilians-Universität Würzburg CY - Würzburg, Germany DA - 2004-06-16 PY - 2004 AN - OPUS4-5375 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Resorbierbarer anorganischer Knochenersatz T2 - 20. Symposium und Workshop "Experimentelle Osteologie" der Orthopädischen Klinik der Martin-Luther-Universität Halle-Wittenberg CY - Halle (Saale), Germany DA - 2004-07-02 PY - 2004 AN - OPUS4-5378 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Werkstoffentwicklung für Medizin und Biotechnologie in der BAM-Projektgruppe "Biowerkstoffe und Implantate" T2 - Eingeladener Vortrag zum Institutskolloquium des Biotechnologisch-Biomedizinischen Zentrums der Universität Leipzig CY - Leipzig, Germany DA - 2004-10-20 PY - 2004 AN - OPUS4-5379 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Entwicklung von resorbierbarem Knochenersatz T2 - Eingeladener Vortag zum "Wissenschaftlichen Dialog" anläßlich der Eröffnung des Implantationszentrums an der Meoclinic Berlin CY - Berlin, Germany DA - 2004-11-13 PY - 2004 AN - OPUS4-5380 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Resorbable Bone Substitution Materials on the Basis of Calcium Phosphates T2 - 2. Treffen des DKG-Arbeitskreises "Glasig-kristalline Multifunktionswerkstoffe" CY - Saarbrücken, Germany DA - 2004-02-26 PY - 2004 AN - OPUS4-5372 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Resorbable bioceramic coated pins: solubility behaviour in vitro and adequate reactions in vivo T2 - IX. Conference of the European Ceramic Society (ECERS) CY - Portorož, Slovenia DA - 2005-06-19 PY - 2005 AN - OPUS4-7814 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Lehmann, Erhard A1 - Stiller, M. A1 - Koch, C. A1 - Ducheyne, P. A1 - Rack, A. A1 - Seligmann, H. A1 - Jonscher, S. A1 - Knabe, C. T1 - A comparative study of the biodegradability of calcium-alkali-orthophosphate ceramics in vitro and in vivo KW - Calcium-alkali-orthophosphate KW - Solubility KW - Biodegradability PY - 2007 SN - 1013-9826 VL - 330-332 SP - 63 EP - 66 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-14528 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Ploska, Ute A1 - Berger, Georg T1 - Spongiosa-like Specimen and Foils of a Biomaterial Composed of Fluorapatite and Calcium Zirconium Phosphate KW - Apatite KW - Calcium zirconium phosphate KW - Spongiosa-like specimen KW - Foil PY - 2007 SN - 1013-9826 VL - 330-332 IS - Bioceramics 19 SP - 443 EP - 446 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-14529 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Marx, Heidi A1 - Berger, Georg A1 - Breitwieser, M. T1 - Prüftechnik für anorganischen Biozement KW - Gillmoore-Needle-Test KW - Initiale Abbindezeit KW - Finale Abbindezeit KW - Härtetest KW - Biozemente PY - 2007 SN - 0016-3538 VL - 51 IS - 2 SP - 106 EP - 108 PB - GIT-Verlag CY - Darmstadt AN - OPUS4-14582 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Ploska, Ute A1 - Berger, Georg A1 - Jörn, Daniela A1 - Willfahrt, Manfred A1 - Hackbarth, Andreas T1 - Calcium titanate reaction layers on TiAl6V4 implants KW - Titan alloy KW - Calcium titanate KW - Reaction layer KW - Implant PY - 2008 SN - 1013-9826 VL - 361-363 SP - 657 EP - 660 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-15899 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bernstein, A. A1 - Nöbel, D. A1 - Mayr, H.O. A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Ploska, Ute A1 - Brandt, J. T1 - Influence of Calcium Zirconium Phosphate Containing Coatings on Mineralization of Bone KW - Ceramics KW - Coating KW - Biomaterial KW - Bone KW - Biocompatibility KW - Surface reaction PY - 2008 SN - 1013-9826 VL - 361-363 SP - 641 EP - 644 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-15900 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Beranic Klopcic, S. A1 - Pribosic, I. A1 - Kosmac, T. A1 - Ploska, Ute A1 - Berger, Georg T1 - The Reactivity of CaTi4(PO4)6 with Alumina and Y-TZP Ceramics KW - Calcium titanium phosphate KW - Alumina KW - Zirconia PY - 2008 SN - 1013-9826 VL - 361-363 SP - 787 EP - 790 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-15901 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gildenhaar, Renate A1 - Berger, Georg A1 - Lehmann, Erhard A1 - Knabe, C. T1 - Development of Alkali Containing Calcium Phosphate Cements KW - Calcium phosphate cement KW - Calcium potassium sodium phosphate KW - Potassium containing apatite KW - Bone substitute materials PY - 2008 SN - 1013-9826 VL - 361-363 SP - 331 EP - 334 PB - Trans Tech Publ. CY - Aedermannsdorf AN - OPUS4-15902 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Berger, Georg T1 - Calciumphosphat-Keramik für den resorbierbaren Knochenersatz T2 - Jahrestagung der Deutschen Keramischen Gesellschaft 2007 CY - Dresden, Germany DA - 2007-03-19 PY - 2007 AN - OPUS4-15863 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -