TY - JOUR A1 - de Oliveira Guilherme Buzanich, Ana A1 - Kulow, Anicó A1 - Kabelitz, Anke A1 - Grunewald, C. A1 - Seidel, R. A1 - Chapartegui-Arias, Ander A1 - Radtke, Martin A1 - Reinholz, Uwe A1 - Emmerling, Franziska A1 - Beyer, S. T1 - Observation of early ZIF-8 crystallization stages with X-ray absorption spectroscopy N2 - The present study investigates early stages of ZIF-8 crystallization up to 5 minutes post mixing of precursor solutions. Dispersive X-ray Absorption Spectroscopy (DXAS) provides a refined understanding of the evolution of the coordination environment during ZIF-8 crystallization. Linear Combination Fiting (LCF) suggests tetrakis(1-methylimidazole)zinc2+ to be a suitable and stable mononuclear structure analogue for some early stage ZIF-8 intermediates. Our results pave the way for more detailed studies on physico-chemical aspects of ZIF-8 crystallization to better control tailoring ZIF-8 materials for specific applications. KW - In-situ KW - XANES KW - ZIF-8 KW - Crystallization PY - 2020 DO - https://doi.org/10.1039/D0SM01356K SN - 1744-6848 VL - 17 IS - 2 SP - 331 EP - 334 PB - Royal Scociety of Chemistry AN - OPUS4-51723 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Abad Andrade, Carlos Enrique A1 - Chapartegui, Ander A1 - Péter, G. T1 - Alcoholism clinical biomarkers and mass spectrometry N2 - Heavy alcohol induces several chronic diseases, including cirrhosis. Consequently, cirrhotic patients need liver transplantation. However, alcoholic patients are not suitable for this. How can be physicians sure of non-alcohol consumption of a potential organ receptor? Monitoring of biomarkers by mass spectrometric techniques is today the most suitable option. This subject was discussed at the Graduate School of Analytical Science Adlershof (SALSA) in Berlin, as a part of a lecture series in analytical science. T2 - Analytical Challenges - School of Analytical Sciences Adlershof CY - Berlin, Germany DA - 12.12.2017 KW - Alcoholism KW - Biomarkers KW - Mass spectrometry KW - Transferrin PY - 2017 AN - OPUS4-43535 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Chapartegui-Arias, Ander A1 - Villajos Collado, José Antonio A1 - Myxa, Anett A1 - Beyer, Sebastian A1 - Falkenhagen, Jana A1 - Schneider, Rudolf A1 - Emmerling, Franziska T1 - Covalently Fluorophore-Functionalized ZIF‑8 Colloidal Particles as a Sensing Platform for Endocrine-Disrupting Chemicals Such as Phthalates Plasticizers N2 - We present the optical sensing of phthalate Esters (PAEs), a group of endocrine-disrupting chemicals. The sensing takes place as changes in the fluorescence emission intensity of aminopyrene covalently bound to the organic ligands of the metal−organic framework compound ZIF-8. In the presence of PAEs, a quenching of the fluorescence emission is observed. We evaluated strategies to engineer colloidal size distribution of the sensing particles to optimize the sensory response to PAEs. A thorough characterization of the modified ZIF-8 nanoparticles included powder X-ray diffractometry, transmission electron microscopy, high-performance liquid chromatography, and photophysical characterization. The presented capability of the fluorophore-functionalized ZIF-8 to sense PAEs complements established methods such as chromatography-based procedures, which cannot be used on-site and paves the way for future developments such as hand-held quick sensing devices. KW - Sensing KW - MOF PY - 2019 DO - https://doi.org/10.1021/acsomega.9b01051 VL - 4 IS - 17 SP - 17090 EP - 17097 PB - ACS AN - OPUS4-49562 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Chapartegui, Ander A1 - Emmerling, Franziska A1 - Schneider, Rudolf T1 - MOFs as optical sensor elements against endocrine disrupting phthalates N2 - The development of optical sensing technologies for Endocrine Disrupting Chemicals (EDCs) was urgently needed to facilitate currently unmet demands on comprehensive monitoring of These substances, thus ensuring consumer safety. T2 - SALSA CY - Berlin, Germany DA - 01.05.2018 KW - MOF KW - Short chained phthalates PY - 2018 AN - OPUS4-46889 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Chapartegui-Arias, Ander A1 - Raysyan, A. A1 - Belenguer, A. M. A1 - Jaeger, Carsten A1 - Tchipilov, Teodor A1 - Prinz, Carsten A1 - Abad Andrade, Carlos Enrique A1 - Beyer, S. A1 - Schneider, Rudolf A1 - Emmerling, Franziska T1 - Tailored mobility in a zeolite imidazolate framework (ZIF) antibody conjugate N2 - Zeolitic imidazolate framework (ZIF) hybrid fluorescent nanoparticles and ZIF antibody conjugates have been synthesized, characterized, and employed in lateral-flow immunoassay (LFIA). The bright fluorescence of the conjugates and the possibility to tailor their mobility gives a huge potential for diagnostic assays. An enzyme-linked immunosorbent assay (ELISA) with horseradish peroxidase (HRP) as label, proved the integrity, stability, and dispersibility of the antibody conjugates, LC-MS/MS provided evidence that a covalent link was established between these metal-organic frameworks and lysine residues in IgG antibodies. KW - ZIF KW - ELISA PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-532096 DO - https://doi.org/10.1002/chem.202100803 SN - 0947-6539 SN - 1521-3765 VL - 27 IS - 36 SP - 9414 EP - 9421 PB - Wiley-VCH CY - Weinheim AN - OPUS4-53209 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Chapartegui, Ander A1 - Emmerling, Franziska A1 - Schneider, Rudolf T1 - Metal-Organic Frameworks as turn on fluorescent optical sensors against endocrine disrupting phthalate plasticizers N2 - The development of quick and simple optical sensing technologies for Endocrine Disrupting Chemicals (EDCs) is needed to facilitate monitoring of these substances to ensure consumer safety. Optical sensing was achieved against phthalates acting as EDC that have host guest interaction with an intercalated Metal-organic framework (MOF), resulting in a fluorescence emission upon excitation. The fluorescent turn-on signal was generated by using a fluorophore with a structural component that has little fluorescence unless excimers are formed. Strategies to engineer functional MOF structures suitable for sensing EDC phthalates were developed, and the characterization of the MOFs with and without present phthalates was done by single crystal XRD, PXRD, RAMAN and Thermogravimetry. Extensive photo-physical characterization of host-guest complexes of different phthalates and the MOF as well as the resulting exciplex fluorescence was performed. Photo physical characterization revealed an analyte specific fluorescence fingerprint that allows discerning even minute changes in chemical structures of the analyte and therefore paving the way for sensing tools in real world analytical applications. The presented capability of MOFs to sense EDCs is envisioned to complement established methods from analytical chemistry such as mass spectrometry based methods which can’t be used on site and are often associated with infrastructural capacity constraints T2 - EURoptrode CY - Naples, Italy DA - 25.03.2018 KW - MOF KW - Short chained Phthalates PY - 2018 AN - OPUS4-46890 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -