TY - JOUR A1 - Villatoro, J. A1 - Zühlke, M. A1 - Riebe, D. A1 - Beitz, T. A1 - Weber, M. A1 - Riedel, Jens A1 - Löhmannsröben, H.-G. T1 - IR-MALDI ion mobility spectrometry: physical source characterization and application as HPLC detector N2 - Infraredmatrix-assisted laser dispersion and ionization(IR-MALDI) in combination with on mobility (IM) spectrometry enables the direct Analysis of biomolecules in aqueous solution. The release of ions directly from an aqueous solution is based on a phase explosion, induced by the Absorption of an IR laser pulse, which disperses the liquid as vapor, nano- and micro-droplets. The ionization process is characterized initially by a broad spatial distribution of the ions, which is a result of complex fluid dynamics and desolvation kinetics. These processes have a profound effect on the shape and width of the peaks in the IM spectra. In this work, the Transport of ions by the phase explosion-induced shockwave could be studied independently from the transport by the electric field. The shockwave-induced mean velocities of the ions at different time scales were determined through IM spectrometry and shadowgraphy. The results show a deceleration of the Ions from 118m∙s−1 at a distance of 400 μm from the liquid surface to 7.1 m∙s−1 at a distance of 10 mm, which is caused by a pileup effect. Furthermore, the desolvation kinetics were investigated and a first-order desolvation constant of 325 ± 50 s−1 was obtained. In the second part, the IR-MALDI-IM spectrometer is used as an HPLC detector for the twodimensional separation of a pesticide mixture. KW - Ion mobility spectrometry KW - IR-MALDI KW - Shadowgraphy KW - Laser PY - 2016 U6 - https://doi.org/10.1007/s12127-016-0208-1 VL - 2016 IS - 4 SP - 197 EP - 207 PB - Springer-Verlag Berlin CY - Heidelberg AN - OPUS4-38467 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -