TY - CONF A1 - Bleul, Regina A1 - Thiermann, Raphael A1 - Saatchi, K. A1 - Häfeli, U.O. A1 - Maskos, M. ED - Parak, W.J. ED - Osinski, M. ED - Yamamoto, K. T1 - Multifunctional nanocarriers for biomedical applications N2 - Polymeric vesicles (Pluronic® L-121) loaded with magnetic nanoparticles (MNP) and an anti-cancer drug (camptothecin) were prepared continuously in a micro mixing device. Characterization by TEM confirmed the successful incorporation of the MNP and DLS measurements showed a relatively narrow size distribution of the hybrid polymersomes. A very high drug loading of camptothecin (100 µg/ml in the polymersome formulation) was reached and a drug release study of loaded magnetic polymersomes has shown a sustained camptothecin release over several days. Carboxylation of Pluronic® L-121 was performed and enabled a further surface functionalization with bombesin, a 14 amino acid peptide, which binds specifically to the GRPR (gastrin releasing peptide receptor). This receptor is often overexpressed in tumor cells (e.g., human prostate cancer cells) and therefore a suitable target for cancer treatment. An additional fluorescence label with Alexa Fluor® 647 allow tracking of the polymersomes e.g., in cell experiments. Relaxivity measurements to evaluate the potential of magnetic polymersomes as MR contrast agent for in vivo imaging are in progress. T2 - Colloidal nanocrystals for biomedical applications VIII CY - San Francisco, CA, USA DA - 2013-02-22 KW - Polymersomes KW - Vesicles KW - Block copolymers KW - Pluronics KW - Drug delivery KW - Micro mixer PY - 2013 SN - 9780819493644 U6 - https://doi.org/10.1117/12.2008194 N1 - Serientitel: Proceedings of SPIE – Series title: Proceedings of SPIE VL - 8595 SP - 85951N-1 - 85951N-9 AN - OPUS4-28488 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -