TY - JOUR A1 - Swart, C. A1 - Jakubowski, Norbert T1 - Update on the status of metrology for metalloproteins JF - Journal of Analytical Atomic Spectrometry N2 - Metalloproteins, which represent about 30 % of the total proteome, are often important markers for distinguishing between healthy and diseased states of patients. As such markers have become increasingly important in clinical diagnostics, some of these proteins are routinely analysed in clinical laboratories. Reliable and comparable results are the basis for the investigation of changes in the proteome due to different health conditions. Nevertheless, for many proteins the results achieved with different routine measurement procedures or in different laboratories vary widely, thus hampering medical insights and the development of treatments. Reference measurement procedures with results traceable to the International System of Units (SI) will also help to greatly improve the performance of routine measurement procedures and, this way, they support the understanding of changes in the metallome. KW - Metalloproteins KW - Traceability KW - Standardization KW - Quantitative proteomics PY - 2016 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-400522 DO - https://doi.org/10.1039/c6ja00181e IS - 9 SP - 1756 EP - 1765 PB - Royal Society of Chemistry (RSC) AN - OPUS4-40052 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -