TY - JOUR A1 - Martínez, R. A1 - Sancenón, F. A1 - Hoffmann, Katrin A1 - Rurack, Knut A1 - Descalzo López, Ana Belén T1 - Materiales híbridos en química analítica JF - Anales de la Real Sociedad Espanola de Química N2 - El desarrollo de receptores sintéticos complejos basados en conceptos de la química supramolecular no garantiza en ocasiones un reconocimiento molecular selectivo. Una alternativa en ciertos aspectos más simple y prometedora es el empleo de materiales híbridos orgánico-inorgánicos preparados mediante la funcionalización de sólidos inorgánicos porosos con receptores sintéticos adecuados. El anclaje de estos sistemas coordinantes a un soporte sólido da lugar a ciertos efectos sinérgicos que no están presentes ni en el material inicial ni en el receptor por separado y que sugieren que estos nuevos materiales híbridos pueden ser empleados en el desarrollo de nuevos sensores y nuevos protocolos de reconocimiento molecular y/o iónico. The development of synthetic receptors based in supramolecular chemistry concepts will no allow a selective molecular recognition. A more simple, convenient and innovative approach relies on the use of organic-inorganic hybrid materials. These hybrid materials will be prepared by the grafting of certain synthetic receptors onto porous inorganic solids. The grafting of these coordinating systems onto a solid support leads to synergic effects that are hardly achievable with only the synthetic receptors or the solids alone. The presence of these synergic effects suggests that these organic-inorganic hybrid materials will be used for the development of novel sensory systems and novel molecular and/or ionic recognitionprotocols. KW - Soportes inorgánicos KW - Receptores sintéticos KW - Materiales híbridos KW - Efectos sinérgicos KW - Química analítica KW - Inorganic supports KW - Synthetic receptors KW - Hybrid materials KW - Synergic effects KW - Analytical chemistry PY - 2007 SN - 1575-3417 VL - 103 IS - 4 SP - 22 EP - 27 PB - Springer AN - OPUS4-17512 LA - spa AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Martínez-Mánez, Ramon A1 - Sancenón, F. A1 - Biyikal, Mustafa A1 - Hecht, Mandy A1 - Rurack, Knut T1 - Mimicking tricks from nature with sensory organic-inorganic hybrid materials JF - Journal of materials chemistry N2 - Design strategies for (bio)chemical systems that are inspired by nature's accomplishments in system design and operation on various levels of complexity are increasingly gaining in importance. Within the broad field of biomimetic chemistry, this article highlights various attempts toward improved and sophisticated sensory materials that rely on the combination of supramolecular (bio)chemical recognition principles and nanoscopic solid structures. Examples range from more established concepts such as hybrid sensing ensembles with improved sensitivity and selectivity or for target analytes for which selectivity is hard to achieve by conventional methods, which were often inspired by protein binding pockets or ion channels in membranes, to very recent approaches relying on target-gated amplified signalling with functionalised mesoporous inorganic supports and the integration of native biological sensory species such as transmembrane proteins in spherically supported bilayer membranes. Besides obvious mimicry of recognition-based processes, selected approaches toward chemical transduction junctions utilizing artificially organized synapses, hybrid ensembles for improved antibody generation and uniquely colour changing systems are discussed. All of these strategies open up exciting new prospects for the development of sensing concepts and sensory devices at the interface of nanotechnology, smart materials and supramolecular (bio)chemistry. KW - Sensorik KW - Supramolekulare Chemie KW - Biomimetik KW - Nanotechnologie KW - Hybridmaterialien PY - 2011 DO - https://doi.org/10.1039/c1jm11210d SN - 0959-9428 SN - 1364-5501 VL - 21 IS - 34 SP - 12588 EP - 12604 PB - Royal Society of Chemistry CY - Cambridge AN - OPUS4-24352 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Martínez-Mánez, Ramon A1 - Sancenón, F. A1 - Hecht, Mandy A1 - Biyikal, Mustafa A1 - Rurack, Knut T1 - Nanoscopic optical sensors based on functional supramolecular hybrid materials JF - Analytical and bioanalytical chemistry N2 - This review highlights how the combination of supramolecular principles and nanoscopic solid structures enables the design of new hybrid sensing ensembles with improved sensitivity and/or selectivity and for the targeting of analytes for which selectivity is hard to achieve by conventional methods. Such ideas are bridging the gap between molecules, materials sciences and nanotechnology. Relevant examples will be detailed, taking into account functional aspects such as (1) enhanced coordination of functionalized solids, (2) enhanced signalling through preorganization, (3) signalling by assembly–disassembly of nanoscopic objects, (4) biomimetic probes utilizing discrimination by polarity and size and (5) distinct switching and gating protocols. These strategies are opening new prospects for sensor research and signalling paradigms at the frontier between nanotechnology, smart materials and supramolecular chemistry. KW - Supramolecular chemistry KW - Optical probes KW - Nanotechnology KW - Hybrid organic-inorganic materials PY - 2011 DO - https://doi.org/10.1007/s00216-010-4198-2 SN - 1618-2642 SN - 1618-2650 VL - 399 IS - 1 SP - 55 EP - 74 PB - Springer CY - Berlin AN - OPUS4-22908 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Pascual, L. A1 - Baroja, I. A1 - Aznar, E. A1 - Sancenón, F. A1 - Marcos, M. Dolores A1 - Murguía, J.R. A1 - Amorós, P. A1 - Rurack, Knut A1 - Martínez-Mánez, Ramon T1 - Oligonucleotide-capped mesoporous silica nanoparticles as DNA-responsive dye delivery systems for genomic DNA detection JF - Chemical communications N2 - New hybrid oligonucleotide-capped mesoporous silica nanoparticles able to detect genomic DNA were designed. KW - Gesteuerte Materialien KW - Mycoplasma KW - Mesoporöse Träger KW - Sonden KW - DNA PY - 2015 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-321357 UR - http://pubs.rsc.org/en/content/articlepdf/2015/cc/c4cc08306g DO - https://doi.org/10.1039/C4CC08306G SN - 0022-4936 SN - 0009-241x SN - 1359-7345 SN - 1364-548x VL - 51 IS - 8 SP - 1414 EP - 1416 PB - Royal Society of Chemistry CY - Cambridge AN - OPUS4-32135 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Climent Terol, Estela A1 - Mondragón, L. A1 - Martínez-Mánez, Ramon A1 - Sancenón, F. A1 - Marcos, M. Dolores A1 - Murguía, J.R. A1 - Amorós, P. A1 - Rurack, Knut A1 - Pérez-Payá, E. T1 - Selective, highly sensitive, and rapid detection of genomic DNA by using gated materials: Mycoplasma detection JF - Angewandte Chemie / International Edition N2 - Come and gate it: DNA-capped mesoporous silica nanoparticles loaded with a dye are used to detect the common contaminate Mycoplasma in real contaminated cell-culture media without needing polymerase chain reaction (PCR) techniques, at a detection limit in the range of 70 DNA genome copies µL-1. KW - DNA KW - Gated materials KW - Mesoporous materials KW - Mycoplasma KW - Sensors PY - 2013 DO - https://doi.org/10.1002/anie.201302954 SN - 1433-7851 SN - 1521-3773 SN - 0570-0833 VL - 52 IS - 34 SP - 8938 EP - 8942 PB - Wiley-VCH CY - Weinheim AN - OPUS4-28976 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Climent Terol, Estela A1 - Gröninger, Delia A1 - Hecht, Mandy A1 - Walter, Astrid A1 - Martínez-Mánez, Ramon A1 - Weller, Michael G. A1 - Sancenón, F. A1 - Amorós, P. A1 - Rurack, Knut T1 - Selective, sensitive, and rapid analysis with lateral-flow assays based on antibody-gated dye-delivery systems: The example of triacetone triperoxide JF - Chemistry - A European journal N2 - Set them free: Brightly fluorescent indicators that are loaded into mesoporous silica nanoparticle carriers, capped with bulky antibodies, are released into the lateral flow of a test strip upon analyte arrival. Integration of the system into a rapid, simple flow test with fluorescence readout is applied for the selective and sensitive determination of the presence of triacetone triperoxide (TATP) as a prototype small-molecule analyte (see figure). KW - Farbstoffe KW - Sprengstoffe KW - Fluoreszenz KW - Immunoassays KW - Mesoporöse Materialien PY - 2013 DO - https://doi.org/10.1002/chem.201300031 SN - 0947-6539 SN - 1521-3765 VL - 19 IS - 13 SP - 4117 EP - 4122 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-29508 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Climent Terol, Estela A1 - Mondragón, L. A1 - Martínez-Mánez, Ramon A1 - Sancenón, F. A1 - Marcos, M. Dolores A1 - Murguía, J.R. A1 - Amorós, P. A1 - Rurack, Knut A1 - Pérez-Payá, E. T1 - Selektiver, hoch empfindlicher und schneller Nachweis genomischer DNA mit gesteuerten Materialien am Beispiel von Mycoplasma JF - Angewandte Chemie N2 - Mit DNA verschlossene und mit Farbstoff beladene mesoporöse Siliciumdioxid-Nanopartikel wurden zum Nachweis von Mycoplasma bis zu einer Nachweisgrenze von ca. 70 genomischen DNA-Kopien pro µL in real kontaminierten Zellkulturmedien ohne die Hilfe von PCR-Techniken eingesetzt. KW - DNA KW - Gesteuerte Materialien KW - Mesoporöse Träger KW - Mycoplasma KW - Sonden PY - 2013 DO - https://doi.org/10.1002/ange.201302954 SN - 0044-8249 SN - 0932-2140 SN - 1521-3757 VL - 125 IS - 34 SP - 9106 EP - 9110 PB - Wiley-VCH CY - Weinheim AN - OPUS4-28970 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - García-Acosta, B. A1 - Comes, M. A1 - Bricks, J.L. A1 - Kudinova, M.A. A1 - Kurdyukov, V.V. A1 - Tolmachev, A.I. A1 - Descalzo López, Ana Belén A1 - Marcos, M. Dolores A1 - Martínez-Mánez, Ramon A1 - Moreno, A. A1 - Sancenón, F. A1 - Soto, J. A1 - Villaescusa, L.A. A1 - Rurack, Knut A1 - Barat, J. M. A1 - Escriche, I. A1 - Amorós, P. T1 - Sensory hybrid host materials for the selective chromo-fluorogenic detection of biogenic amines JF - Chemical communications KW - Biogene Amine KW - Histamin KW - Farbreaktion KW - Pyralium-Farbstoffe KW - Fluoreszenz KW - Hybrid-Materialien PY - 2006 SN - 0022-4936 SN - 0009-241x SN - 1359-7345 SN - 1364-548x IS - 21 SP - 2239 EP - 2241 PB - Royal Society of Chemistry CY - Cambridge AN - OPUS4-12563 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Ros-Lis, J.V. A1 - Martínez-Mánez, Ramon A1 - Sancenón, F. A1 - Soto, J. A1 - Rurack, Knut A1 - Weißhoff, Hardy T1 - Signalling Mechanisms in Anion-Responsive Push-Pull Chromophores: The Hydrogen-Bonding, Deprotonation and Anion-Exchange Chemistry of Functionalized Azo Dyes JF - European journal of organic chemistry N2 - A family of azo dyes containing amide (1), urea (2), thiourea (3), carbamate (4) or amino (5) hydrogen-bond donating groups were synthesized and their response toward anions was studied. Acetonitrile solutions of 1-5 show bright yellow colours, due to charge-transfer bands in the 375-400 nm region, slightly modulated by the electron donor strength of the group attached to the 4 end of the 4-nitroazobenzene scaffold. Anions of different shape and size (i.e., spherical F-,Cl-, Br- and I-, planar and tetrahedral oxoanions such as NO3-, H2PO4- and HSO4-, carboxylates such as acetate and benzoate and the linear anions cyanide and thiocyanate) were employed in the recognition studies. Two different effects were distinguished: (i) bathochromic shifts of <40 nm to pale orange, due to anion coordination, and (ii) strong red shifts of ca. 200 nm with a concomitant colour change to blue, due to deprotonation. This behaviour was explained as a balance between the deprotonation tendency of the binding sites in the different receptors and the proton affinities of the anions. Semiempirical calculations were carried out to evaluate the hydrogen bond-donating abilities of the anions and the dyes and a good correlation with the experimentally found values was observed. Stability constants for the receptor-anion complexes were determined spectrophotometrically and the different responses toward fluoride and acetate were assessed by NMR titration experiments. Finally, as a special case, we also report the use of this family of compounds as colorimetric carbon dioxide sensors through reaction with the unprotonated forms of the azo dyes. KW - Chromophores KW - Dyes/Pigments KW - Chemosensors KW - Gas sensors KW - Carbon dioxide PY - 2007 DO - https://doi.org/10.1002/ejoc.200601111 SN - 1434-193X SN - 1099-0690 VL - 2007 IS - 15 SP - 2449 EP - 2458 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-16081 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Calero, P. A1 - Hecht, Mandy A1 - Martínez-Mánez, Ramon A1 - Sancenón, F. A1 - Soto, J. A1 - Vivancos, J.L. A1 - Rurack, Knut T1 - Silica nanoparticles functionalised with cation coordination sites and fluorophores for the differential sensing of anions in a quencher displacement assay (QDA) JF - Chemical communications N2 - In conjunction with quenching metal ions, silica nanoparticles carrying terpyridine coordination sites and sulforhodamine B signalling units were employed for the differential fluorometric recognition of anions. KW - Hybridmaterial KW - Silica-Nanopartikel KW - Fluoreszenz KW - Anionen KW - Verdrängungsassay PY - 2011 DO - https://doi.org/10.1039/c1cc13039k SN - 0022-4936 SN - 0009-241x SN - 1359-7345 SN - 1364-548x VL - 47 IS - 38 SP - 10599 EP - 10601 PB - Royal Society of Chemistry CY - Cambridge AN - OPUS4-24489 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -