TY - JOUR A1 - Gnutzmann, Tanja A1 - Nguyen, Thi Yen A1 - Rademann, K. A1 - Emmerling, Franziska T1 - Solvent-triggered crystallization of polymorphs studied in situ JF - Crystal growth & design N2 - The crystallization of a highly polymorphic compound was studied in situ by combined time-resolved X-ray diffraction and Raman spectroscopy. Any influences of solid surfaces, temperature, and humidity on the crystallization were omitted by the use of a specially designed acoustic levitator. Investigations of polymorphic phase transitions during the crystallization process in different solvents allowed a structure assignment from first crystalline assemblies to final crystalline form. For the first time, it was possible to yield pure phases of selected polymorphs of the model compound ROY (5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile) directly from solution. The influence of the solvent on the final products and transient phases during the crystallization process was elucidated. KW - Polymorphism KW - Crystallization KW - In situ WAXS KW - In situ Raman spectroscopy KW - ROY PY - 2014 DO - https://doi.org/10.1021/cg501287v SN - 1528-7483 VL - 14 IS - 12 SP - 6445 EP - 6450 PB - American Chemical Society CY - Washington, DC, USA AN - OPUS4-32583 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -