TY - JOUR A1 - Lindner, Uwe A1 - Lingott, Jana A1 - Richter, Silke A1 - Jiang, W. A1 - Jakubowski, Norbert A1 - Panne, Ulrich T1 - Analysis of Gadolinium-based contrast agents in tap water with a new hydrophilic interaction chromatography (ZIC-cHILIC) hyphenated with inductively coupled plasma mass spectrometry JF - Analytical and bioanalytical chemistry N2 - Hydrophilic interaction chromatography (HILIC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) were optimised for the direct determination of gadolinium-based contrast agents in tap water. In comparison to our previous work, a new developed zwitterionic HILIC column (ZIC-cHILIC) was used for speciation of Gd-containing contrast agents. The limit of quantification (LOQ) for the five contrast agents Gd-BOPTA, Gd-DPTA-BMA, Gd-BT-DO3A, Gd-DOTA and Gd-DTPA are in the range of 5–12 ng Gd per litre. Additionally, a new internal standard, Pr-DOTA, was investigated to correct intensity drifts, minor and major changes in the sample volumes and possible matrix effects. With the speciation method described, tap water samples from the area of Berlin were analysed and for the first time, three Gd species, Gd-BT-DO3A, Gd-DOTA and Gd-BOPTA, were found in tap water samples at concentrations of about 10–20 ng Gd per litre. These are the same Gd species which have been previously detected predominantly in surface waters of the Berlin area. KW - Gadolinium-based contrast agents KW - Hydrophilic interaction chromatography (HILIC) KW - Speciation KW - Inductively coupled plasma mass spectrometry (ICP-MS) KW - Internal standard KW - Berlin tap water PY - 2015 DO - https://doi.org/10.1007/s00216-014-8368-5 SN - 1618-2642 SN - 1618-2650 VL - 407 IS - 9 SP - 2415 EP - 2422 PB - Springer CY - Berlin AN - OPUS4-32982 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Lingott, Jana A1 - Lindner, Uwe A1 - Telgmann, Lena A1 - Esteban-Fernández, Diego A1 - Jakubowski, Norbert A1 - Panne, Ulrich T1 - Gadolinium-uptake by aquatic and terrestrial organisms-distribution determined by laser ablation inductively coupled plasma mass spectrometry JF - ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS N2 - The uptake of gadolinium containing chelates by plants and animals grown in exposed water or on soil irrigated with exposed water was investigated. Gd contrast agents was studied by monitoring the elemental distribution with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). KW - Gadolinium-uptake KW - Speciation KW - HILIC KW - ICP-MS PY - 2016 DO - https://doi.org/10.1039/c5em00533g SN - 2050-7887 VL - 18 IS - 2 SP - 200 EP - 207 PB - Royal Society of Chemistry CY - Cambridge, UK AN - OPUS4-36281 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Lindner, Uwe A1 - Lingott, Jana A1 - Richter, Silke A1 - Jakubowski, Norbert A1 - Panne, Ulrich T1 - Speciation of gadolinium in surface water samples and plants by hydrophilic interaction chromatography hyphenated with inductively coupled plasma mass spectrometry JF - Analytical and bioanalytical chemistry N2 - Hydrophilic interaction chromatography (HILIC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) was optimized for speciation analysis of gadolinium-based contrast agents in environmental samples, in particular surface river waters and plants. Surface water samples from the Teltow channel, near Berlin, were investigated over a distance of 5 km downstream from the influx of a wastewater treatment plant. The total concentration of gadolinium increased significantly from 50 to 990 ngL-1 due to the influx of the contrast agents. After complete mixing with the river water, the concentration remained constant over a distance of at least 4 km. Two main substances [Dotarem® (Gd-DOTA) and Gadovist® (Gd-BT-DO3A)] have been identified in the river water using standards. A gadolinium-based contrast agent, possibly Gd-DOTA (Dotarem®), was also detected in water plant samples taken from the Teltow channel. Therefore, uptake of contrast agents [Gadovist® (Gd-BTDO3A), Magnevist® (Gd-DTPA), Omniscan® (Gd-DTPA-BMA), Dotarem® (Gd-DOTA), and Multihance® (Gd-BOPTA)] by plants was investigated in a model experiment using Lepidium sativum (cress plants). HILIC–ICP-MS was used for identification of different contrast agents, and a first approach for quantification using aqueous standard solutions was tested. For speciation analysis, all investigated contrast agents could be extracted from the plant tissues with a recovery of about 54 % for Multihance® (Gd-BOPTA) up to 106 % for Gadovist® (Gd-BT-DO3A). These experiments demonstrate that all contrast agents investigated are transported from the roots to the leaves where the highest content was measured. KW - Gadolinium-based contrast agents KW - Hydrophilic interaction chromatography (HILIC) KW - Speciation KW - Inductively coupled plasma mass spectrometry (ICP-MS) KW - Plants KW - Surface water PY - 2013 DO - https://doi.org/10.1007/s00216-012-6643-x SN - 1618-2642 SN - 1618-2650 VL - 405 IS - 6 SP - 1865 EP - 1873 PB - Springer CY - Berlin AN - OPUS4-27929 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -