TY - JOUR A1 - Kneipp, Janina A1 - Kneipp, H. A1 - McLaughlin, M. A1 - Brown, D. A1 - Kneipp, K. T1 - In Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates N2 - Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM studies indicate the formation of nanoaggregates providing optimum SERS enhancement for ultrasensitive probing inside the endosomal compartment. The results have implications for medical and biotechnology applications of SERS nanosensors in cells. PY - 2006 U6 - https://doi.org/10.1021/nl061517x SN - 1530-6984 SN - 1530-6992 VL - 6 IS - 10 SP - 2225 EP - 2231 PB - American Chemical Society CY - Washington, DC AN - OPUS4-13935 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -