TY - JOUR A1 - Löwa, N. A1 - Knappe, Patrick A1 - Wiekhorst, F. A1 - Eberbeck, D. A1 - Thünemann, Andreas A1 - Trahms, L. T1 - How hydrodynamic fractionation influences MPI performance of resovist JF - IEEE transactions on magnetics N2 - We studied the magnetic resonance imaging liver contrast agent Resovist by a variety of magnetic measurement techniques, in order to understand the physical mechanism of their high magnetic particle imaging (MPI) performance, wirh a focus on the size-dependent contributions of the MPI signal. To this end, we used asymmetric flow field-flow fractionation to separate Resovist into a set of fractions with defined hydrodynamic diameters. The individual fractions were magnetically characterized by static magnetization and magnetorelaxometry measurements to obtain the corresponding effective magnetic anisotropy and effective size distribution parameters. In addition, the MPI performance of each fraction was assessed by magnetic particle spectroscopy. We observed an MPI signal gain of about 100% with respect to their iron amount for the best fraction. Relating these finding to the results from magnetic characterization provides more insight into mechanisms of MPI performance of Resovist. This knowledge may help to improve the design of novel MPI tracers. KW - Nanotechnology KW - Nanoparticles KW - Asymmetric flow field-flow fractionation KW - Magnetic nanoparticles (MNP) KW - Magnetic particle imaging (MPI) KW - Magnetic particle spectroscopy KW - Magnetic separation KW - Magnetorelaxometry (MRX) KW - Resovist PY - 2015 DO - https://doi.org/10.1109/TMAG.2014.2326833 SN - 0018-9464 SN - 1941-0069 VL - 51 IS - 2 SP - 5300104-1 EP - 5300104-4 PB - Institute of Electrical and Electronics Engineers CY - New York, NY AN - OPUS4-33337 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -