TY - JOUR A1 - Bornemann-Pfeiffer, Martin A1 - Kern, Simon A1 - Jurtz, N. A1 - Thiede, Tobias A1 - Kraume, M. A1 - Maiwald, Michael T1 - Design and validation of an additively manufactured flowCell–static mixer combination for inline NMR spectroscopy JF - Industrial & Engineering Chemistry Research N2 - There have been an increasing number of publications on flow chemistry applications of compact NMR. Despite this, there is so far no comprehensive workflow for the technical design of flow cells. Here, we present an approach that is suitable for the design of an NMR flow cell with an integrated static mixing unit. This design moves the mixing of reactants to the active NMR detection region within the NMR instrument, presenting a feature that analyses chemical reactions faster (5–120 s region) than other common setups. During the design phase, the targeted mixing homogeneity of the components was evaluated for different types of mixing units based on CFD simulation. Subsequently, the flow cell was additively manufactured from ceramic material and metal tubing. Within the targeted working mass flow range, excellent mixing properties as well as narrow line widths were confirmed in validation experiments, comparable to common glass tubes. KW - Inline NMR Spectroscopy KW - Integrated Processes KW - Reaction Monitoring KW - Process Analytical Technology KW - Flow Chemistry KW - Static Mixing KW - Modular Production PY - 2019 UR - https://pubs.acs.org/doi/abs/10.1021/acs.iecr.9b03746 DO - https://doi.org/10.1021/acs.iecr.9b03746 SN - 0888-5885 SN - 1520-5045 N1 - Geburtsname von Bornemann-Pfeiffer, Martin: Bornemann, M. - Birth name of Bornemann-Pfeiffer, Martin: Bornemann, M. VL - 58 IS - 42 SP - 19562 EP - 19570 PB - American Chemical Society CY - Washington AN - OPUS4-49041 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bornemann-Pfeiffer, Martin A1 - Kern, Simon A1 - Maiwald, Michael A1 - Meyer, Klas T1 - Calibration-Free Chemical Process and Quality Control Units as Enablers for Modular Production JF - Chemie Ingenieur Technik N2 - Modular chemical production is a tangible translation of the digital transformation of the process industry for specialty chemicals. In particular, it enables the speeding-up of process development and thus a quicker time to market by flexibly connecting and orchestrating standardised physical modules and bringing them to life (i.e., parameterising them) with digitally accumulated process knowledge. We focus on the specific challenges of chemical process and quality control, which in its current form is not well suited for modular production and provide possible approaches and examples of the change towards direct analytical methods, analytical model transfer or machine-supported processes. KW - Modular Production KW - Chemical Process Control KW - Process Analytical Technology KW - Digital Transformation KW - Industry 4.0 PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-517264 DO - https://doi.org/10.1002/cite.202000150 SN - 1522-2640 VL - 93 IS - 1-2 SP - 62 EP - 70 PB - Wiley-VCH CY - Weinheim AN - OPUS4-51726 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -