TY - CONF A1 - Jakubowski, Norbert T1 - Short Course: ICP-MS with Sector Field Devices T2 - Winter Conference on Plasma Spectrochemistry 2014 T2 - Winter Conference on Plasma Spectrochemistry 2014 CY - Amelia Island, FL, USA DA - 2014-01-05 PY - 2014 AN - OPUS4-30247 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Jakubowski, Norbert A1 - Lindner, Uwe A1 - Lingott, Jana A1 - Panne, Ulrich A1 - Richter, Silke T1 - Speciation and imaging of Gd containing MRI contrast agents in environmental samples by ICP-MS T2 - SCIX 2014 T2 - SCIX 2014 CY - Reno, NV, USA DA - 2014-09-28 PY - 2014 AN - OPUS4-31897 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Müller, Larissa A1 - Traub, Heike A1 - Jakubowski, Norbert A1 - Drescher, Daniela A1 - Baranov, Vladimir A1 - Kneipp, Janina T1 - Trends in single-cell analysis by use of ICP-MS JF - Analytical and bioanalytical chemistry N2 - The analysis of single cells is a growing research field in many disciplines such as toxicology, medical diagnosis, drug and cancer research or metallomics, and different methods based on microscopic, mass spectrometric, and spectroscopic techniques are under investigation. This review focuses on the most recent trends in which inductively coupled plasma mass spectrometry (ICP-MS) and ICP optical emission spectrometry (ICP-OES) are applied for single-cell analysis using metal atoms being intrinsically present in cells, taken up by cells (e.g., nanoparticles), or which are artificially bound to a cell. For the latter, especially element tagged antibodies are of high interest and are discussed in the review. The application of different sample introduction systems for liquid analysis (pneumatic nebulization, droplet generation) and elemental imaging by laser ablation ICP-MS (LA-ICP-MS) of single cells are highlighted. Because of the high complexity of biological systems and for a better understanding of processes and dynamics of biologically or medically relevant cells, the authors discuss the idea of 'multimodal spectroscopies.' KW - Bioanalytical methods KW - Cell systems/single cell analysis KW - Mass spectrometry/ICP-MS PY - 2014 DO - https://doi.org/10.1007/s00216-014-8143-7 SN - 1618-2642 SN - 1618-2650 VL - 406 IS - 27 SP - 6963 EP - 6977 PB - Springer CY - Berlin AN - OPUS4-31717 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -