TY - GEN A1 - Jakubowski, Norbert A1 - Müller, Larissa A1 - Kneipp, Janina A1 - Esteban-Fernández, Diego A1 - Traub, Heike A1 - Herrmann, Antje A1 - Schellenberger, E. A1 - Panne, Ulrich T1 - BIO - and immuno-imaging by use of laser ablation ICP-MS N2 - Imuno-histochemical staining (IHC) of cancer biomarker on tissue sections is one of the most important analytical techniques for cancer diagnosis although standardization and quality management is tedious and differ significantly from clinic to clinic. Combining established IHC staining strategies with modern quantitative methods would increase it`s potential. We used element mass spectrometry (ICP-MS) and a new ink-jet printed internal standardization approach in combination with IHC staining. The printing strategy was utilized to improve elemental image resolution and reproducibility of paraffin embedded breast cancer tissue sections in laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) after conventional IHC staining as a model system to investigate the new capabilities of this technique. T2 - Ringvorlesung Analytik CY - Humboldt Universität zu Berlin DA - 10.06.2016 KW - Laser ablation KW - Bio-Imaging KW - Immuno-Assays PY - 2016 AN - OPUS4-36476 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -