TY - JOUR A1 - Martínez-Mánez, Ramon A1 - Sancenón, F. A1 - Biyikal, Mustafa A1 - Hecht, Mandy A1 - Rurack, Knut T1 - Mimicking tricks from nature with sensory organic-inorganic hybrid materials N2 - Design strategies for (bio)chemical systems that are inspired by nature's accomplishments in system design and operation on various levels of complexity are increasingly gaining in importance. Within the broad field of biomimetic chemistry, this article highlights various attempts toward improved and sophisticated sensory materials that rely on the combination of supramolecular (bio)chemical recognition principles and nanoscopic solid structures. Examples range from more established concepts such as hybrid sensing ensembles with improved sensitivity and selectivity or for target analytes for which selectivity is hard to achieve by conventional methods, which were often inspired by protein binding pockets or ion channels in membranes, to very recent approaches relying on target-gated amplified signalling with functionalised mesoporous inorganic supports and the integration of native biological sensory species such as transmembrane proteins in spherically supported bilayer membranes. Besides obvious mimicry of recognition-based processes, selected approaches toward chemical transduction junctions utilizing artificially organized synapses, hybrid ensembles for improved antibody generation and uniquely colour changing systems are discussed. All of these strategies open up exciting new prospects for the development of sensing concepts and sensory devices at the interface of nanotechnology, smart materials and supramolecular (bio)chemistry. KW - Sensorik KW - Supramolekulare Chemie KW - Biomimetik KW - Nanotechnologie KW - Hybridmaterialien PY - 2011 U6 - https://doi.org/10.1039/c1jm11210d SN - 0959-9428 SN - 1364-5501 VL - 21 IS - 34 SP - 12588 EP - 12604 PB - Royal Society of Chemistry CY - Cambridge AN - OPUS4-24352 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Hecht, Mandy A1 - Climent Terol, Estela A1 - Biyikal, Mustafa A1 - Sancenón, F. A1 - Martínez-Mánez, Ramon A1 - Rurack, Knut T1 - Gated hybrid delivery systems: En route to sensory materials with inherent signal amplification N2 - Hybrid nanoparticles with a large specific surface area are a particularly exciting vehicle for delivery applications. Such highly porous or container-like structures, usually prepared from silica and frequently from gold, can incorporate a large number of chemical substances such as drug and/or indicator molecules. When equipped with a chemically or physically addressable gating function at the openings of the voids, the release of the cargo can be controlled at will. Because many more molecules can be stored as cargo in the pores of the support than there are functional groups as anchoring sites for the gating entities attached to the outer surface (for efficient pore capping), the systems possess inherent features of (signal) amplification. The present article will introduce various design strategies for different types of physical (light, temperature, magnetism) and chemical (pH, metal ions, anion, small organic molecules, enzymes) stimuli in connection with drug and indicator release. We will highlight exciting aspects of combining both features in theranostic applications and will stress which requirements still have to be met by many of the systems to be readily applicable in a sensory context. KW - Delivery systems KW - Hybrid materials KW - Molecular gates KW - Sensing KW - Theranostics KW - Freisetzungssysteme KW - Hybridmaterialien KW - Molekulare Gatter KW - Sensorik KW - Theranostik PY - 2013 U6 - https://doi.org/10.1016/j.ccr.2013.03.020 SN - 0010-8545 VL - 257 IS - 17-18 SP - 2589 EP - 2606 PB - Elsevier CY - Amsterdam AN - OPUS4-28940 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -