TY - JOUR A1 - Ammann, Dominic A1 - Becker, Roland A1 - Nehls, Irene T1 - Stability of ethyl glucuronide in hair reference materials after accelerated aging N2 - Two different hair reference materials, one produced from authentic hair displaying an ethyl glucuronide (EtG) content of about 25 pg/mg and one obtained by fortification of blank hair to an EtG level of 85 pg/mg were submitted to accelerated aging between 4 degrees C and 60 degrees C for periods between one and 24 months. Subsequently, the EtG content was determined in the aged samples and untreated reference samples stored at -22 degrees C under repeatability conditions following the so-called isochronous approach. The EtG content remained stable even at 40 degrees C for 24 months and at 60 degrees C over six months. This is in contrast to many organic analytes contained in trace concentrations in diverse matrices. A slight but significant increase of the recovered EtG in case of authentic hair samples having been exposed for 24 months between 4 degrees C and 60 degrees C may be due to a temperature-driven process that allows increased recoveries of the physiologically embedded EtG. KW - Alcohol marker KW - Micropulverization KW - HPLC-MS/MS KW - Fortification KW - Long term stability PY - 2015 U6 - https://doi.org/10.1016/j.forsciint.2015.09.015 SN - 0379-0738 SN - 1872-6283 VL - 257 SP - 337 EP - 340 PB - Elsevier Ireland Ldt. CY - Amsterdam [u.a.] AN - OPUS4-34940 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -