TY - GEN A1 - Jung, C. M. A1 - Heintz, A. A1 - Kraus, Werner A1 - Wunderlich, G. A1 - Leibnitz, Peter A1 - Pietzsch, H.-J. A1 - Kropp, J. A1 - Deussen, A. A1 - Spies, H. ED - Marino, N. T1 - Technetium- and Rhenium-Labelled Fatty Acids as Model Compounds for Myocardial Metabolism Imaging N2 - In an attempt to develop new technetium-based radiopharmaceuticals for the non-invasive diagnosis of oxidative myocardial metabolism, rhenium model compounds according to the ‚3+1' mixed ligand approach as well as the organometallic tricarbonyl-design were synthesized. The geometrical impact of different chelates on the integrity of the fatty acid head structure was determined by single crystal X-ray analyses. To evaluate the diagnostic potential of the analogous Technetium-99m compounds, fatty acid complexes of the ‚3+1' mixed ligand type were prepared on n.c.a.-level and studied in the isolated constant-flow-perfused guinea pig heart model; compared to established [123I]Iodine-labelled fatty acid radiotracers, the tested Technetium-99m derivatives showed a specific, however significantly lower myocardial extraction rate. T2 - 6th International Symposium on Technetium in Chemistry and Nuclear Medicine CY - Bressanone, Italy DA - 2002-09-04 KW - Fatty acids KW - Metabolism KW - Myocardial Imaging KW - Rhenium KW - Technetium-99m PY - 2002 UR - http://www.fzd.de/db/!Publications?pSelYear=2002&pLang=en&pNid=0&pSelWithSubmitted=0&pSelSort=TITEL&pSelPublForm=4&pSelPage=2 SN - 88-86281-73-0 N1 - Serientitel: Technetium, rhenium and other metals in chemistry and nuclear medicine – Series title: Technetium, rhenium and other metals in chemistry and nuclear medicine VL - 6 IS - 6 SP - 443 EP - 445 PB - SGEditoriali CY - Padova AN - OPUS4-1999 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Pietzsch, H.-J. A1 - Seifert, S. A1 - Drews, A. A1 - Syhre, R. A1 - Spies, H. A1 - Leibnitz, Peter A1 - Tisato, F. A1 - Refosco, F. T1 - Novel technetium(III) mixed-ligand chelates for the design of lipophilic complexes stable in vivo PY - 2001 UR - http://www3.interscience.wiley.com/journal/3209/toc SN - 0362-4803 SN - 1099-1344 SN - 0022-2135 VL - 44 IS - 1 SP - 39 PB - Wiley CY - London AN - OPUS4-1557 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Jung, C. M. A1 - Kraus, Werner A1 - Leibnitz, Peter A1 - Pietzsch, H.-J. A1 - Kropp, J. A1 - Spies, H. T1 - Synthesis and First Crystal Structure of Rhenium Complexes derived from omega-Functionalized Fatty Acids as Model Compounds of Technetium Tracers for Myocardial Metabolism Imaging N2 - In an attempt to develop new technetium-based radiopharmaceuticals for the noninvasive diagnosis of myocardial metabolism, we have synthesized three examples of novel metal-containing fatty acid derivatives according to the 3+1 mixed-ligand and the Schiff base/tricarbonyl design. The chelates contain the metal core in the oxidation states +5 and +1, respectively, and are attached to the end-position of a fatty acid chain. The complex formation was accomplished by ligand-exchange reactions with three different rhenium precursors, whereas the inactive rhenium metal was utilized as a surrogate of the technetium radionuclide. The molecular structures of the fatty acid complexes 7, 10 and 14 were determined by single-crystal X-ray diffraction analyses and impressively show a general problem in technetium tracer research, namely the significant structural alterations of bioactive molecules by coordination even to small metal chelates. KW - Rhenium KW - Technetium KW - Fatty acids KW - Drug research KW - Radiopharmaceuticals PY - 2002 DO - https://doi.org/10.1002/1099-0682(200205)2002:5<1219::AID-EJIC1219>3.0.CO;2-N SN - 1434-1948 SN - 1099-0682 VL - 2002 IS - 5 SP - 1219 EP - 1225 PB - Wiley-VCH Verl. CY - Weinheim AN - OPUS4-1552 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Aree, T. A1 - Saenger, W. A1 - Leibnitz, Peter A1 - Hoier, H. T1 - Crystal structure of heptakis(2,6-di-O-methyl)-β-cyclodextrin dihydrate: A water molecule in an apolar cavity N2 - Heptakis(2,6-di-O-methyl)-β-cyclodextrin crystallized from water at 18 °C as dihydrate (DIMEB·2 H₂O) in the monoclinic space group P2₁ with unit cell dimensions a=15.2415(5), b=10.6391(4), c=23.3239 (8) Å, β=101.798(1)°. X-ray analysis reveals a torus-like macrocycle stabilized by systematic hydrogen bonds O-3–H··O-2’ and C-6–H··O-5’ between adjacent glucose residues. The O-6–CH₃ methoxy groups of three glucose units are directed toward but do not close the cavity. Both ends of the cavity are closed by adjacent molecules which are related by the characteristics of ‘cage type’ crystal packing. One water molecule is included in the apolar cavity of the torus and has very high anisotropic thermal displacement factor due to lack of hydrogen bonding interactions to DIMEB, while the other one is located in an intermolecular void and forms hydrogen bonds to O-3 and O-6 oxygen atoms. KW - β-Cyclodextrin KW - Dimethylated β-cyclodextrin KW - Inclusion complexes KW - Hydrogen bonding PY - 1999 DO - https://doi.org/10.1016/S0008-6215(99)00033-6 SN - 0008-6215 N1 - Zu dieser Veröffentlichung existiert ein Corrigendum, das in der Zeitschrift "Carbohydrate research" veröffentlicht wurde, Jg. 318 (1999), H. 1-4, S. 201, DOI: 10.1016/S0008-6215(99)00145-7. Dieses Corrigendum ist in der hiesigen PDF-Datei enthalten. - There is a corrigendum for this publication that was published in the journal "Carbohydrate research", vol. 318 (1999), iss. 1-4, p. 201, doi: 10.1016/S0008-6215(99)00145-7. This corrigendum is included in the present pdf file. VL - 315 IS - 3-4 SP - 199 EP - 205 PB - Elsevier CY - Amsterdam AN - OPUS4-63052 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -