TY - JOUR A1 - Ivanow, Alexander A1 - Yudina, N. V. A1 - Malzeva, E. A1 - Mathies, Helena T1 - Research of biostimulation and detoxfication properties of humic acids of various origins in the conditions of petropolluted soil KW - Humic acids KW - Peats KW - Biostimulation KW - Detoxification KW - Petropolluted soil PY - 2007 SN - 1029-5151 SN - 1029-5143 IS - 1 SP - 99 EP - 103 PB - Izdat. Altajskogo Gos. Univ. CY - Barnaul AN - OPUS4-19099 LA - rus AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Stephan, Ina A1 - Leithoff, H. A1 - Peek, R.-D. T1 - Microbial conversion of wood treated with salt preservatives KW - Detoxification KW - Salt preservatives KW - Wood waste KW - Disposal KW - Copper tolerant microbes KW - Antrodia vaillantii KW - Poria placenta KW - Oxalic acid PY - 1996 SN - 0025-5270 VL - 30 IS - 3 SP - 179 EP - 199 PB - Duncker & Humblot CY - Berlin AN - OPUS4-1296 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Stephan, Ina A1 - Nimz, H. A1 - Peek, R.-D. T1 - Detoxification of salt-impregnated wood by organic acids in a pulping process N2 - The paper descibes a novel method to detoxify pine wood (Pinus silvestris L.) treated with CCB-, CCF- CC-, and Cu-HDO-type salt preservatives. In the process of biological detoxification organic acids produced by strains of Antrodia vaillantii and other brown rot fungi are used for the dissolution of the previously fixed inorganic compounds. These findings are the basis for applying an acid pulping process (FORMACELL) developed by Nimz and Schone (1992) at the BFH, Hamburg, to detoxify salt impregnated wood waste with a mixture of acetic and formic acid. First results achieved with wood chips from treated poles after approximately 20 years of service life show that the obtained pulp contains less than 100 ppm of Cr and Cu. The pulp properties were neither influenced by the Cr and Cu ions nor by the age of the poles. The extracted quantities of Cr and Cu remain with the lignin whereas the acids are evaporated and recycled in the pulping process. T2 - 24th Annual meeting of the International Research Group on Wood Preservation CY - Orlando, FL, USA DA - 1993-05-16 KW - Detoxification KW - Wood waste KW - Disposal KW - Acidification KW - Pulping KW - CCB KW - CC KW - CCF KW - CuHDO PY - 1993 UR - http://www.irg-wp.com/irgdocs/details.aspx?id=d44a2d82-2c63-4a45-bfc3-193e23215b4f N1 - Serientitel: IRG WP – Series title: IRG WP IS - 93-50012 SP - 1 EP - 11 PB - IRG CY - Stockholm AN - OPUS4-4447 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Kittler, Katrin A1 - Fessard, V. A1 - Maul, Ronald A1 - Hurtaud-Pessel, D. T1 - CYP3A4 activity reduces the cytotoxic effects of okadaic acid in HepaRG cells N2 - The biotoxin okadaic acid (OA), produced by dinoflagellates in marine environment, can accumulate in sponges and shellfish. Consumption of contaminated shellfish induces acute toxic effects such as diarrhea, nausea, vomiting, and abdominal pain. CYP3A4, one of the most important human xenobiotic metabolizing enzymes, is supposed to be involved in the metabolism of OA. Aim of our study was to evaluate the role of CYP3A4 in OA in vitro metabolism as well as in cell cytotoxicity in parallel. Therefore, a metabolic competent HepaRG cell line was exposed to OA with and without addition of the CYP3A4 inhibitor ketoconazole. Without the inhibitor, two mono-hydroxylated metabolites could be identified, whereas in its presence, no metabolites could be detected. Confirmation of the formed metabolites was accomplished by measuring the exact masses and investigating the fragmentation pattern. Data obtained from cytotoxicity assays showed that OA cytotoxicity is reduced when CYP3A4 is active. Thus, hydroxylation appears to be a crucial step for metabolic OA detoxification. KW - Okadaic acid KW - Cytochrome P-450 KW - Hydroxylation KW - Stability KW - Detoxification KW - Phase I metabolism PY - 2014 DO - https://doi.org/10.1007/s00204-014-1206-x SN - 0340-5761 SN - 1432-0738 VL - 88 IS - 8 SP - 1519 EP - 1526 PB - Springer CY - Berlin ; Heidelberg [u.a.] AN - OPUS4-31567 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -