TY - CONF A1 - Hahn, Marc Benjamin A1 - Solomun, Tihomir A1 - Sturm, Heinz T1 - DNA strand break yields by OH-radicals, low energy electrons and prehydrated electrons N2 - Universität Berlin Radiation damage to biomolecules such as DNA, is the reason to treat cancer via radiation therapy. The understanding of the molecular processes and the quantification of the underlying damaging mechanisms is necessary to develope more efficient irradiation protocols for cancer therapy. Thereby damage to DNA is of key interest due to its central role in reproduction and mutation. Due to the high amount of water in biological tissue, most of the damage is caused by the secondary particles which are produced by the interaction of ionizing radiation with water. Thereby a multitude of species are produced, e.g. kinetic low energy electrons, prehydrated electrons, OH-radicals and ions. The quantification of the contribution to DNA damage by the various species is of interest. Here we present an experimental approach to disentangle their relative DNA strand break yields. Plasmid DNA (pUC19 ) is irradiated in water with electrons under the presence of different scavengers. The presented preliminary results reveal the relative contributions of OH-radicals, low energy electrons and prehydrated electrons and their DNA single and double strand break yields. T2 - DPG-Frühjahrstagung der Sektion Kondensierte Materie gemeinsam mit der EPS CY - Berlin, Germany DA - 11.03.2018 KW - DNA KW - Radiation damage KW - Dosimetry KW - Low energy electrons KW - Hydroxyl radicals KW - Geant4 KW - Prehydrated electrons KW - Scavenger KW - Radiation damage to DNA KW - Plasmid DNA KW - Strand breaks KW - Double strand breaks KW - Single strand breaks PY - 2018 AN - OPUS4-44566 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -