TY - JOUR A1 - Batzdorf, Lisa A1 - Zientek, Nicolai A1 - Rump, Doreen A1 - Fischer, Franziska A1 - Maiwald, Michael A1 - Emmerling, Franziska T1 - Make and break - Facile synthesis of cocrystals and comprehensive dissolution studies JF - Journal of Molecular Structure N2 - Mechanochemistry is increasingly used as a ‘green alternative’ for synthesizing various materials including pharmaceutical cocrystals. Herein, we present the mechanochemical synthesis of three new cocrystals containing the API carbamazepine (cocrystals CBZ:Indometacin 1:1, CBZ:Benzamide 1:1, and CBZ:Nifedipine 1:1). The mechanochemical reaction was investigated in situ documenting a fast and complete reaction within one minute. Online NMR spectroscopy proved the direct influence of the dissolution behaviour of the coformers to the dissolution behaviour of the API carbamazepine. The dissolution behaviour of the organic cocrystals is compared to the behaviour of the pure drug indicating a general applicability of this approach for detailed cocrystal dissolution studies. KW - Cocrystals KW - Carbamazepine KW - Mechanochemistry KW - Powder diffraction KW - Online NMR spectroscopy PY - 2017 DO - https://doi.org/10.1016/j.molstruc.2016.11.063 SN - 0022-2860 SN - 1872-8014 VL - 1133 SP - 18 EP - 23 AN - OPUS4-38664 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Emmerling, Franziska T1 - Synthesis and Structural Characterization of Cocrystals T2 - International School of Crystallography, 46th Course: The Future of Dynamic Structural Science T2 - International School of Crystallography, 46th Course: The Future of Dynamic Structural Science CY - Erice, Sicily, Italy DA - 2013-05-31 PY - 2013 AN - OPUS4-32502 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Emmerling, Franziska T1 - Mechanochemical synthesis and characterisation of cocrystals and metal organic compounds T2 - 170. Farady Discussion 'Mechanochemistry: From Functional Solids to Single Molecules' T2 - 170. Farady Discussion 'Mechanochemistry: From Functional Solids to Single Molecules' CY - Montreal (Canalda) DA - 2014-05-21 PY - 2014 AN - OPUS4-32397 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Fischer, Franziska A1 - Wilke, Manuel A1 - Panne, Ulrich A1 - Emmerling, Franziska T1 - Fast ex situ Analysis of mechanochemical Syntheses and Characterization of Cocrystals and Metal Organic Compounds T2 - 3. Berliner Chemie Symposium des JungChemikerForums Berlin T2 - 3. Berliner Chemie Symposium des JungChemikerForums Berlin CY - Berlin, Germany DA - 2014-04-09 PY - 2014 N1 - Geburtsname von Batzdorf, Lisa: Tröbs, L. - Birth name of Batzdorf, Lisa: Tröbs, L. AN - OPUS4-30596 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Zientek, Nicolai A1 - Maiwald, Michael A1 - Emmerling, Franziska T1 - Crystal Structures and Dissolution Behavior of Carbamazepine Cocrystals T2 - Adlershofer Forschungsforum T2 - Adlershofer Forschungsforum CY - Berlin, Germany DA - 2013-11-12 PY - 2013 N1 - Geburtsname von Batzdorf, Lisa: Tröbs, L. - Birth name of Batzdorf, Lisa: Tröbs, L. AN - OPUS4-29896 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Nguyen, Thi Yen A1 - Wilke, Manuel A1 - Emmerling, Franziska T1 - Synthese- und Kristallisationsuntersuchungen mittels insitu Synchrotron XRD T2 - Workshop "Zeit und temperaturaufgelöste Röntgenbeugung" T2 - Workshop "Zeit und temperaturaufgelöste Röntgenbeugung" CY - Pfinztal, Germany DA - 2013-11-14 PY - 2013 N1 - Geburtsname von Batzdorf, Lisa: Tröbs, L. - Birth name of Batzdorf, Lisa: Tröbs, L. AN - OPUS4-29895 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Rump, Doreen A1 - Emmerling, Franziska A1 - Panne, Ulrich T1 - Strukturelle Charakterisierung von Cokristallen T2 - Anakon 2013 T2 - Anakon 2013 CY - Essen, Germany DA - 2013-03-04 PY - 2013 N1 - Geburtsname von Batzdorf, Lisa: Tröbs, L. - Birth name of Batzdorf, Lisa: Tröbs, L. AN - OPUS4-28287 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Rump, Doreen A1 - Panne, Ulrich A1 - Emmerling, Franziska T1 - Synthese und Charakterisierung von Cokristallen T2 - 7. Interdisziplinäres Doktorandenseminar T2 - 7. Interdisziplinäres Doktorandenseminar CY - Berlin, Germany DA - 2013-02-24 PY - 2013 N1 - Geburtsname von Batzdorf, Lisa: Tröbs, L. - Birth name of Batzdorf, Lisa: Tröbs, L. AN - OPUS4-28286 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Zientek, Nicolai A1 - Batzdorf, Lisa A1 - Kraume, M. A1 - Emmerling, Franziska A1 - Maiwald, Michael T1 - Online-NMR-Methoden zur Analyse des Auflösungsverhaltens von pharmazeutischen Cokristallen T2 - 8. Kolloquium Arbeitskreis Prozessanalytik T2 - 8. Kolloquium Arbeitskreis Prozessanalytik CY - Berlin, Germany DA - 2012-12-03 KW - Quantitative Online-NMR-Spektroskopie KW - Cokristalle KW - Auflösungskinetik PY - 2012 SN - 978-3-9815360-1-0 N1 - Geburtsname von Batzdorf, Lisa: Tröbs, L. - Birth name of Batzdorf, Lisa: Tröbs, L. IS - P12 SP - 40 AN - OPUS4-28267 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Batzdorf, Lisa A1 - Wenzel, Klaus-Jürgen A1 - Panne, Ulrich A1 - Emmerling, Franziska T1 - Reorganization of a Zn Oxalate Bipyridine Structure at high Temperatures T2 - Fourth Joint BER II and BESSY II Users Meeting T2 - Fourth Joint BER II and BESSY II Users Meeting CY - Berlin, Germany DA - 2012-12-12 PY - 2012 N1 - Geburtsname von Batzdorf, Lisa: Tröbs, L. - Birth name of Batzdorf, Lisa: Tröbs, L. AN - OPUS4-27478 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -