65294 2025 eng 1 22 preprint Cornell University Ithaca, NY 0 -- -- -- At the onset of viral outbreaks, broad-spectrum antiviral materials are crucial before specific therapeutics become available. We report scalable, biodegradable black phosphorus (BP) hybrids that provide mutation-resilient virucidal protection. BP sheets, produced via an optimized mechanochemical process, are covalently functionalized with 2-azido-4,6-dichloro- 1,3,5-triazine to form P=N bonds. Fucoidan, a sulfated polysaccharide with intrinsic antiviral activity, and hydrophobic chains are then incorporated to achieve irreversible viral deactivation. The material exhibits strong antiviral inhibition and complete virucidal activity against multiple viruses, including recent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. It maintains high biocompatibility, remains effective against viral mutations, and is shelf stable for at least five month. The combination of biodegradability, scalable synthesis, and synergistic antiviral and virucidal mechanisms establishes BP-conjugates as a new class of highly efficient antivirals. They offer a broad spectrum antiviral solutions that could bridge the gap between antiviral medicines and general antiseptics. arxiv.org 10.48550/arXiv.2510.12854 2331-8422 urn:nbn:de:kobv:b43-652941 publish false true 0 Allgemeines Deutsches Urheberrecht Na Xing Jasmin Er Ricardo M. Vidal Sandhya Khadka Robert Schusterbauer Maik Rosentreter Ranen Etouki Rameez Ahmed Taylor Page Philip Nickl Obida Bawadkji Anja Wiesner Jörg Radnik Vasile-Dan Hodoroaba Kai Ludwig Jakob Trimpert Ievgen Donskyi eng uncontrolled Black phosphorus eng uncontrolled Antiviral materials eng uncontrolled Functionalization eng uncontrolled Biodegradability eng uncontrolled Sheets Ingenieurwissenschaften und zugeordnete Tätigkeiten 6 Materialchemie 6.1 Oberflächen- und Dünnschichtanalyse Material Datei für die Öffentlichkeit verfügbar ("Open Access") Graue Literatur Advanced Materials Preprints der BAM Bundesanstalt für Materialforschung und -prüfung (BAM) https://opus4.kobv.de/opus4-bam/files/65294/2510.12854v1.pdf https://opus4.kobv.de/opus4-bam/files/65294/12_12_SI.pdf