65086 2025 eng 15662 15677 48 13 article Royal Society of Chemistry (RSC) 1 -- -- -- In this work, we have developed hierarchically porous phosphate-based glasses (PPGs) as novel materials capable of promoting wound closure and simultaneously delivering antibacterial effects at the glass-biological tissue interface. PPGs are characterised by extended porosity, which enhances the controlled release of therapeutic ions, whilst facilitating cell infiltration and tissue growth. Two series of PPGs in the systems P2O5–CaO–Na2O–CuO and P2O5–CaO–Na2O–Ga2O3 with (CuO and Ga2O3 0, 1, 5 and 10 mol%) were manufactured using a supramolecular sol–gel synthesis strategy. Significant wound healing promotion (up to 97%) was demonstrated using a human ex vivo wound model. A statistically significant reduction of the bacterial strains Staphylococcus aureus and Escherichia coli was observed in both series of PPGs, particularly those containing copper. All PPGs exhibited good cytocompatibility on keratinocytes (HaCaTs), and analysis of PPG dissolution products over a 7-day period demonstrated controlled release of phosphate anions and Ca, Na, Cu, and Ga cations. These findings indicate that Cu- and Ga-loaded PPGs are promising materials for applications in soft tissue regeneration given their antibacterial capabilities, in vitro biocompatibility with keratinocytes and ex vivo wound healing properties at the biomaterial-human tissue interface. Journal of Materials Chemistry B 2050-750X 10.1039/d5tb01945a urn:nbn:de:kobv:b43-650867 true journal-article http://creativecommons.org/licenses/by/3.0/ crossref PersonAuthorFirstName_1,PersonAuthorLastName_1,PersonAuthorIdentifierOrcid_1,PersonAuthorFirstName_2,PersonAuthorLastName_2,PersonAuthorFirstName_3,PersonAuthorLastName_3,PersonAuthorIdentifierOrcid_3,PersonAuthorFirstName_4,PersonAuthorLastName_4,PersonAuthorFirstName_5,PersonAuthorLastName_5,PersonAuthorFirstName_6,PersonAuthorLastName_6,PersonAuthorFirstName_7,PersonAuthorLastName_7,PersonAuthorIdentifierOrcid_7,PersonAuthorFirstName_8,PersonAuthorLastName_8,PersonAuthorIdentifierOrcid_8,PersonAuthorFirstName_9,PersonAuthorLastName_9,PersonAuthorFirstName_10,PersonAuthorLastName_10,PersonAuthorFirstName_11,PersonAuthorLastName_11,PersonAuthorIdentifierOrcid_11,PersonAuthorFirstName_12,PersonAuthorLastName_12,PersonAuthorFirstName_13,PersonAuthorLastName_13,PersonAuthorIdentifierOrcid_13,PublisherName,TitleMain_1,Language,TitleAbstract_1,TitleParent_1,PageFirst,PageLast,Issue,Volume,PublishedYear,IdentifierIssn,Enrichmentlocal_crossrefLicence doi-import 11.12.2025 false true Creative Commons - CC BY - Namensnennung 4.0 International Charlotte A. Berry Katre Reinart Glen J. Smales Holly N. Wilkinson Matthew J. Hardman Sofia Marchesini William Lee Eveliny Tomás Nery Zarrin Moghaddam Agron Hoxha Mónica Felipe-Sotelo Jorge Gutierrez-Merino Daniela Carta eng uncontrolled Porous glass eng uncontrolled Phosphates eng uncontrolled Wound healing materials eng uncontrolled Antibacterial eng uncontrolled X-ray scattering eng uncontrolled MOUSE Ingenieurwissenschaften und zugeordnete Tätigkeiten 6 Materialchemie 6.5 Synthese und Streuverfahren nanostrukturierter Materialien Material Verlagsliteratur Datei für die Öffentlichkeit verfügbar ("Open Access") Wissenschaftliche Artikel der BAM Advanced Materials Bundesanstalt für Materialforschung und -prüfung (BAM) https://opus4.kobv.de/opus4-bam/files/65086/d5tb01945a.pdf