63833 2025 eng poster 0 -- -- -- Disinfectants are important to provide hygiene in sensitive areas, to prevent the spread of infections and to preserve materials from biodeterioration. Bacteria can survive disinfection through phenotypic and genotypic adaptation. Phenotypic heterogeneity may be linked to the ability to evolve disinfectant tolerance. The genetic factors which determine the survival of disinfection remain largely unknown. Here, we investigate the effects of phenotypic heterogeneity on the evolvability of disinfectant tolerance. Furthermore, using a whole-genome CRISPRi-library, we uncover genetic determinants that are important for the survival of disifenction. µClub Seminar Berlin Berlin, Germany 23.05.2025 23.05.2025 publish false true Niclas Nordholt eng uncontrolled Biocides eng uncontrolled Heterogeneity eng uncontrolled Biocide resistance eng uncontrolled Evolution eng uncontrolled Disinfectants Sanitär- und Kommunaltechnik; Umwelttechnik 4 Material und Umwelt 4.1 Biologische Materialschädigung und Referenzorganismen Umwelt Umwelt-Material-Interaktionen Datei im Netzwerk der BAM verfügbar ("Closed Access") Präsentation