63478 2025 eng 1 6 13527 conferenceobject SPIE Prague, Czech Republic 1 -- -- -- The development of novel photonic integrated microchips (PIC) is a promising approach to allow for the convenient detection of key biomarkers in complex matrices through multichannel real-time analysis in a highly compact package. This study reports the successful development and application of a backside released CMOS chip designed for the multichannel real-time detection of biomarkers. Operating at the C-band at approx. 1550 nm, the microchip features three dedicated detection sensors in addition to a reference sensor, enabling simultaneous analysis of multiple biomarkers. The compact and highly miniaturized design of this microchip, with a footprint of just 1 mm², positions it as promising candidate for point-of-care diagnostics and personalized medicine applications. This technology opens a path to transform biomarker detection across various medical fields, offering rapid, reliable, and cost-effective diagnostic solutions. In conclusion, the presented multichannel photonic microchips signify a substantial leap forward in real-time biomarker detection, providing a highly capable platform for future research and clinical applications. SPIE Proceedings 10.1117/12.3056453 978-1-5106-8850-6 SPIE Optics + Optoelectronics 2025 Prague, Czech Republic 07.04.2025 11.04.2025 publish 11.08.2025 Robert Tannenberg Martin Paul Tabea Fünning Christoph Schuhmann Michael G. Weller Patrick Steglich eng uncontrolled Photonic integrated circuit eng uncontrolled Ring resonator eng uncontrolled Real-time detection eng uncontrolled Multiplexing eng uncontrolled Semiconductor eng uncontrolled CMOS eng uncontrolled C-reactive protein eng uncontrolled CRP eng uncontrolled Biomarker Analytische Chemie 1 Analytische Chemie; Referenzmaterialien 1.5 Proteinanalytik Chemie und Prozesstechnik Chemische Charakterisierung und Spurenanalytik Verlagsliteratur Datei im Netzwerk der BAM verfügbar ("Closed Access")