45421 2018 eng poster 0 -- -- -- Sialic acid (SA) is a cell surface glycan, which has a decisive role in many cell activities including differentiation, proliferation, and the immune response. The amount of SA has been found to correlate with cancer, with an upregulation on more aggressive cancers. Therefore, there is a great interest in developing methods for detection of SA on cancer cells. We are screening SA on cancer cell lines by using fluorescent molecularly imprinted polymers, SA-MIPs. Macrophages, which evolve from mono-cytes, are well known for their extraordinary ability to phagocytose foreign objects. This could lead to the hypothesis that the SA-MIPs can be recognized by macrophages as foreign object; thus leading to internalization and potentially degradation. We have demonstrated that SA-MIPs can be detected after incubation with the RAW macrophage cells, with increasing fluorescence over time. The microscopy analysis shows that the RAW cells ingest the SA-MIP particles. This information is important when planning to use SA-MIPs in future in vivo applications. 1st National Meeting of the Swedish Chemical Society Lund University, Sweden 17.06.2018 20.06.2018 L. Sternbaek eng uncontrolled Sialic acid eng uncontrolled MIPs eng uncontrolled Macrophages Analytische Chemie Ingenieurwissenschaften und zugeordnete Tätigkeiten Datei im Netzwerk der BAM verfügbar ("Closed Access") Präsentation