44620 2018 eng poster 0 -- -- -- The compatible solute and osmolyte ectoine is an effective protectant of biomolecules and whole cells against heating, freezing and high salinity. The protection of cells (human Keratinocytes) by ectoine against ultraviolet radiation was also reported by various authors, although the underlying mechanism is not yet understood. We present results on the irradiation of biomolecules (DNA) with ionizing radiation (high energy electrons) in fully aqueous environment in the presence of ectoine and high salt concentrations. The results demonstrate an effective radiation protection of DNA by ectoine against the induction of single strand breaks by ionizing radiation. The effect is explained by an increased in low-energy electron scattering at the enhanced free-vibrational density of states of water due to ectoine, as well as the action of ectoine as an OH-radical scavenger. This was demonstrated by Raman spectroscopy, electron paramagnetic resonance (EPR) and Monte-Carlo simulations (Geant4). urn:nbn:de:kobv:b43-446202 Poster basiert auf: https://nbn-resolving.org/urn:nbn:de:kobv:b43-419332 DPG-Frühjahrstagung der Sektion Kondensierte Materie gemeinsam mit der EPS Berlin, Germany 11.03.2018 16.03.2018 Creative Commons - Namensnennung 3.0 Marc Benjamin Hahn eng uncontrolled Ionizing radiation eng uncontrolled Ectoine eng uncontrolled Radiation damage eng uncontrolled Radiation protection eng uncontrolled Dosimetry eng uncontrolled Ectoin eng uncontrolled Ectoine radiation protection eng uncontrolled Compatible solute eng uncontrolled Osmolyte eng uncontrolled Aqueous solution eng uncontrolled OH-radical eng uncontrolled Radical scavenger eng uncontrolled Hydroxyl radical eng uncontrolled Hydroxyectoine eng uncontrolled Ectoine radical scavenger eng uncontrolled Low energy electrons eng uncontrolled Geant4 Analytische Chemie Datei für die Öffentlichkeit verfügbar ("Open Access") Präsentation BAM Präsentationen Bundesanstalt für Materialforschung und -prüfung (BAM) https://opus4.kobv.de/opus4-bam/files/44620/ectoine_protects_biomolecules_against_ionizing_radiation_damage_dpg2018.pdf