44565 2018 eng poster 0 -- -- -- The quantification of radiation induced damage to DNA in aqueous en- vironment is of fundamental interest for dosimetry and its application in radiation-therapy and protection. We present a combined experi- mental and simulational approach to quantify and compare radiation induced damage to biomolecules in liquid environment for a wide range of primary radiation sources e. g. photons, electrons or ions and tar- gets, such as DNA, proteins or cells.[1] To show its viability, we will apply this method to an experimentally challenging systems, the di- rect irradiation of plasmid DNA (pUC19) in water with electrons as primary particles. Here we combine Geant4 electron-scattering simula- tions with calculations concerning the diffusion and convection induced movement of the biomolecules, within a coarse-grained model of the irradiated liquid. Additionally a microscopic target model for the plas- mid DNA based on the relation of lineal energy and radiation quality is used to calculate the effective target volume. DPG-Frühjahrstagung der Sektion Kondensierte Materie gemeinsam mit der EPS Berlin, Germany 11.03.2018 16.03.2018 Marc Benjamin Hahn eng uncontrolled DNA eng uncontrolled Radiation damage eng uncontrolled Dosimetry eng uncontrolled Microdosimetry eng uncontrolled Low energy electrons eng uncontrolled Hydroxyl radicals eng uncontrolled Monte-Carlo simulation eng uncontrolled Geant4 eng uncontrolled Electron scattering eng uncontrolled Target volume eng uncontrolled DNA damage eng uncontrolled DNA radiation damage Analytische Chemie Datei im Netzwerk der BAM verfügbar ("Closed Access") Präsentation