41252 2017 eng poster 0 -- -- -- Simvastatin is a prominent member of the statin family, a class of antilipidemic drugs widely used in the treatment of high plasma cholesterol levels, and thus in the prevention of atherosclerosis and cardiovascular diseases. Simvastatin is typically employed as a solid and it is well known that, in this case, the detection and characterization of polymorphism is of considerable importance. Polymorphs differ by their packing arrangements and also, occasionally, by the conformations of the molecules in the crystal lattice. These structural variations are normally reflected by differences in physical properties, such as solubility and dissolution rate in a given media, which may significantly affect the bioavailability of a drug. The lack of control of polymorphism can, therefore, play havoc with the safe use of a drug. COST Action CM1402 Lincoln, United Kingdom 26.06.2017 26.06.2017 F. M. Piedada eng uncontrolled Polymorphism eng uncontrolled X-ry Diffraction Ingenieurwissenschaften und zugeordnete Tätigkeiten Datei im Netzwerk der BAM verfügbar ("Closed Access") Präsentation