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  <doc>
    <id>40229</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>72</pageFirst>
    <pageLast>73</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace>Frankfurt a. M.</publisherPlace>
    <creatingCorporation>DECHEMA e. V., Frankfurt</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Design and Validation of a Compact NMR Analyser</title>
    <abstract language="eng">Monitoring chemical reactions is the key to chemical process control. Today, mainly&#13;
optical online methods are applied. NMR spectroscopy has a high potential for direct&#13;
loop process control. Compact NMR instruments based on permanent magnets&#13;
are robust and relatively inexpensive analysers, which feature advantages like low&#13;
cost, low maintenance, ease of use, and cryogen-free operation. Instruments for&#13;
online NMR measurements equipped with a flow-through cell, possessing a good&#13;
signal-to-noise-ratio, sufficient robustness, and meeting the requirements for&#13;
integration into industrial plants (i.e., explosion safety and fully automated data&#13;
analysis) are currently not available off the rack.&#13;
Intensified continuous processes are in focus of current research. Flexible (modular)&#13;
chemical plants can produce different products using the same equipment with short&#13;
down-times between campaigns and quick introduction of new products to the&#13;
market. In continuous flow processes online sensor data and tight closed-loop control&#13;
of the product quality are mandatory. If these are not available, there is a huge risk of&#13;
producing large amounts of out-of-spec (OOS) products. This is addressed in the&#13;
European Unionʼs Research Project CONSENS (Integrated Control and Sensing)&#13;
by development and integration of smart sensor modules for process monitoring and&#13;
control within such modular plant setups.&#13;
The presented NMR module is provided in an explosion proof housing of 57 x 57 x&#13;
85 cm module size and involves a compact 43.5 MHz NMR spectrometer together&#13;
with an acquisition unit and a programmable logic controller for automated data&#13;
preparation (phasing, baseline correction) and evaluation. Indirect Hard Modeling&#13;
(IHM) was selected for data analysis of the low-field NMR spectra. A set-up for&#13;
monitoring continuous reactions in a thermostated 1/8” tubular reactor using&#13;
automated syringe pumps was used to validate the IHM models by using high-field&#13;
NMR spectroscopy as analytical reference method.</abstract>
    <parentTitle language="eng">Processdings of 4th European Conference on Process Analytics and Control Technology (EuroPACT 2017)</parentTitle>
    <enrichment key="eventName">4th European Conference on Process Analytics and Control Technology (EuroPACT 2017)</enrichment>
    <enrichment key="eventPlace">Potsdam, Germany</enrichment>
    <enrichment key="eventStart">10.05.2017</enrichment>
    <enrichment key="eventEnd">12.05.2017</enrichment>
    <author>Simon Kern</author>
    <author>Svetlana Guhl</author>
    <author>Klas Meyer</author>
    <author>Andrea Paul</author>
    <author>Lukas Wander</author>
    <author>Patrick Gräßer</author>
    <author>Michael Maiwald</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Prozessanalytik</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reaction Monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Online NMR Spectrsocopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Process Analytical Technology</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Industrie 4.0</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>EuroPACT</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Graue Literatur</collection>
  </doc>
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