<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>48062</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>3037</pageFirst>
    <pageLast>3046</pageLast>
    <pageNumber/>
    <edition/>
    <issue>14</issue>
    <volume>411</volume>
    <type>article</type>
    <publisherName>Springer Nature</publisherName>
    <publisherPlace>Heidelberg</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Flexible automation with compact NMR spectroscopy for continuous production of pharmaceuticals</title>
    <abstract language="eng">Modular plants using intensified continuous processes represent an appealing concept for the production of pharmaceuticals. It can improve quality, safety, sustainability, and profitability compared to batch processes; besides, it enables plug-and-produce reconfiguration for fast product changes. To facilitate this flexibility by real-time quality control, we developed a solution that can be adapted quickly to new processes and is based on a compact nuclear magnetic resonance (NMR) spectrometer. The NMR sensor is a benchtop device enhanced to the requirements of automated chemical production including robust evaluation of sensor data. Beyond monitoring the product quality, online NMR data was used in a new iterative optimization approach to maximize the plant profit and served as a reliable reference for the calibration of a near-infrared (NIR) spectrometer. The overall approach&#13;
was demonstrated on a commercial-scale pilot plant using a metal-organic reaction with pharmaceutical relevance.</abstract>
    <parentTitle language="eng">Analytical and Bioanalytical Chemistry</parentTitle>
    <identifier type="doi">10.1007/s00216-019-01752-y</identifier>
    <identifier type="issn">1618-2642</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-480623</identifier>
    <identifier type="issn">1618-2650</identifier>
    <enrichment key="date_peer_review">27.05.2019</enrichment>
    <enrichment key="RelatedIdentifier">https://nbn-resolving.org/urn:nbn:de:kobv:b43-480630</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Simon Kern</author>
    <author>Lukas Wander</author>
    <author>Klas Meyer</author>
    <author>Svetlana Guhl</author>
    <author>A. R. Gottu Mukkula</author>
    <author>M. Holtkamp</author>
    <author>M. Salge</author>
    <author>C. Fleischer</author>
    <author>N. Weber</author>
    <author>S. Engell</author>
    <author>Andrea Paul</author>
    <author>M. Pereira Remelhe</author>
    <author>Michael Maiwald</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>NMR Spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>NIR Spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Real-time process monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Real-time quality control</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Continuous processes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CONSENS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Data Fusion</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/48062/ABC_411_2019_3037-3046_Kern.pdf</file>
  </doc>
</export-example>
