<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>47093</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>559</pageFirst>
    <pageLast>564</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>411</volume>
    <type>article</type>
    <publisherName>Springer-Verlag GmbH</publisherName>
    <publisherPlace>Berlin, Heidelberg</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Gold nanoparticles as labels for immunochemical analysis using laser ablation inductively coupled plasma mass spectrometry</title>
    <abstract language="eng">In this paper, we describe the labelling of antibodies by gold nanoparticles (AuNPs) with diameters of 10 and 60 nm with detection by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Additionally, the AuNPs labelling strategy is compared with commercially available labelling reagents based on MeCAT (metal coded affinity tagging). Proof of principle experiments based on dot blot experiments were performed. The two labelling methods investigated were compared by sensitivity and limit of detection (LOD). The absolute LODs achieved were in the range of tens of picograms for AuNP labelling compared to a few hundred picograms by the MeCAT labelling.</abstract>
    <parentTitle language="eng">Analytical and Bioanalytical Chemistry</parentTitle>
    <identifier type="doi">10.1007/s00216-018-1300-7</identifier>
    <identifier type="issn">1618-2642</identifier>
    <identifier type="issn">1618-2650</identifier>
    <enrichment key="date_peer_review">30.01.2019</enrichment>
    <author>M. Tvrdonova</author>
    <author>M. Vlcnovska</author>
    <author>L. Pompeiano Vanickova</author>
    <author>V. Kanicky</author>
    <author>V. Adam</author>
    <author>Lena Ascher</author>
    <author>Norbert Jakubowski</author>
    <author>M. Vaculovicova</author>
    <author>T. Vaculovic</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticle</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>LA-ICP-MS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Labeling</value>
    </subject>
    <collection role="ddc" number="546">Anorganische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
</export-example>
