<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>32734</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2518</pageFirst>
    <pageLast>2529</pageLast>
    <pageNumber/>
    <edition/>
    <issue>9</issue>
    <volume>13</volume>
    <type>article</type>
    <publisherName>RSC</publisherName>
    <publisherPlace>Cambridge</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications</title>
    <abstract language="eng">Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.</abstract>
    <parentTitle language="eng">Organic &amp; biomolecular chemistry</parentTitle>
    <identifier type="old">35810</identifier>
    <identifier type="doi">10.1039/c4ob02334j</identifier>
    <identifier type="issn">1477-0520</identifier>
    <identifier type="issn">1477-0539</identifier>
    <enrichment key="date_peer_review">12.03.2015</enrichment>
    <author>P.M.R. Pereira</author>
    <author>B. Korsak</author>
    <author>B. Sarmento</author>
    <author>Rudolf Schneider</author>
    <author>R. Fernandes</author>
    <author>J.P.C. Tomé</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Therapeutische Antikörper</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Krebstherapie</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Photodynamische Therapie</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Konjugate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Porphyrine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Phthalocyanine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Chlorine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Kopplungsmethoden</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
</export-example>
