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    <completedYear/>
    <publishedYear>2025</publishedYear>
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    <language>eng</language>
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    <pageLast>10717</pageLast>
    <pageNumber/>
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    <issue>11</issue>
    <volume>19</volume>
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    <publisherName>ACS Publications</publisherName>
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    <title language="eng">Interfacing with the Brain: How Nanotechnology Can Contribute</title>
    <abstract language="eng">Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain−machine interfaces have changed over time, along with the available technology.&#13;
Mechanical levers and cable winches were used to move parts of the brain during the mechanical age. Sophisticated electronic wiring and remote control have arisen during the electronic age, ultimately leading to plug-and-play computer interfaces. Nonetheless, our brains are so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, is that most of our technology is mechanically and/or electrically engineered, whereas the brain is a living, dynamic entity. As a result, these worlds are difficult to interface with one another. Nanotechnology, which encompasses engineered solid-state objects and integrated circuits, excels at small length scales of single to a few hundred nanometers and, thus, matches the sizes of biomolecules, biomolecular assemblies, and parts of cells. Consequently, we envision nanomaterials and nanotools as opportunities to interface with the brain in alternative ways. Here, we review the existing literature on the use of nanotechnology in brain−machine interfaces and look forward in discussing perspectives and limitations based on the authors’ expertise across a range of complementary disciplines from neuroscience, engineering, physics, and chemistry to biology and medicine, computer science and mathematics, and social science and jurisprudence. We focus on nanotechnology but also include information from related fields when useful and complementary.</abstract>
    <parentTitle language="eng">ACS Nano</parentTitle>
    <identifier type="doi">10.1021/acsnano.4c10525</identifier>
    <identifier type="issn">1936-086X</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-634893</identifier>
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    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>A. A. A. Ahmed</author>
    <author>N. Alegret</author>
    <author>B. Almeida</author>
    <author>R. Alvarez-Puebla</author>
    <author>A. M. Andrews</author>
    <author>L. Ballerini</author>
    <author>J. J. Barrios-Capuchino</author>
    <author>C. Becker</author>
    <author>R. H. Blick</author>
    <author>S. Bonakdar</author>
    <author>I. Chakraborty</author>
    <author>X. Chen</author>
    <author>J. Cheon</author>
    <author>G. Chilla</author>
    <author>A. L. C. Conceicao</author>
    <author>J. Delehanty</author>
    <author>M. Dulle</author>
    <author>A. L. Efros</author>
    <author>M. Epple</author>
    <author>M. Fedyk</author>
    <author>N. Feliu</author>
    <author>M. Feng</author>
    <author>R. Fernandez-Chacon</author>
    <author>I. Fernandez-Cuesta</author>
    <author>N. Fertig</author>
    <author>S. Förster</author>
    <author>J. A. Garrido</author>
    <author>M. George</author>
    <author>A. H. Guse</author>
    <author>N. Hampp</author>
    <author>J. Harberts</author>
    <author>J. Han</author>
    <author>H. R. Heekeren</author>
    <author>U. G. Hofmann</author>
    <author>M. Holzapfel</author>
    <author>H. Hosseinkazemi</author>
    <author>Y. Huang</author>
    <author>P. Huber</author>
    <author>T. Hyeon</author>
    <author>S. Ingebrandt</author>
    <author>M. Ienca</author>
    <author>A. Iske</author>
    <author>Y. Kang</author>
    <author>G. Kasieczka</author>
    <author>D.-H. Kim</author>
    <author>K. Kostarelos</author>
    <author>J.-H. Lee</author>
    <author>K.-W. Lin</author>
    <author>S. Liu</author>
    <author>X. Liu</author>
    <author>Y. Liu</author>
    <author>C. Lohr</author>
    <author>V. Mailänder</author>
    <author>L. Maffongelli</author>
    <author>S. Megahed</author>
    <author>A. Mews</author>
    <author>M. Mutas</author>
    <author>L. Nack</author>
    <author>N. Nakatsuka</author>
    <author>T. G. Oertner</author>
    <author>A. Offenhäusser</author>
    <author>M. Oheim</author>
    <author>B. Otange</author>
    <author>F. Otto</author>
    <author>E. Patrono</author>
    <author>B. Peng</author>
    <author>A. Picchiotti</author>
    <author>F. Pierini</author>
    <author>M. Pötter-Nerger</author>
    <author>M. Pozzi</author>
    <author>A. Pralle</author>
    <author>M. Prato</author>
    <author>B. Qi</author>
    <author>P. Ramos-Cabrer</author>
    <author>Ute Resch-Genger</author>
    <author>N. Ritter</author>
    <author>M. Rittner</author>
    <author>S. Roy</author>
    <author>F. Santoro</author>
    <author>N. W. Schuck</author>
    <author>F. Schulz</author>
    <author>E. Seker</author>
    <author>M. Skiba</author>
    <author>M. Sosniok</author>
    <author>H. Stephan</author>
    <author>R. Wang</author>
    <author>T. Wang</author>
    <author>Karl David Wegner</author>
    <author>P. S. Weiss</author>
    <author>M. Xu</author>
    <author>C. Yang</author>
    <author>S. S. Zargarin</author>
    <author>Y. Zeng</author>
    <author>Y. Zhou</author>
    <author>D. Zhu</author>
    <author>R. Zierold</author>
    <author>W. J. Parak</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoneuro interface</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Brain-on-a-chip</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanostructured interface</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrode arrays</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Neuro-implants</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Advanced nanomaterials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Quality assurance</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.2 Biophotonik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Material</collection>
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    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Advanced Materials</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
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    <file>https://opus4.kobv.de/opus4-bam/files/63489/QD Neuron_ASC Nano_2025.pdf</file>
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  <doc>
    <id>53062</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
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    <language>eng</language>
    <pageFirst>56</pageFirst>
    <pageLast>73</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>284</volume>
    <type>article</type>
    <publisherName>Wiley-Blackwell</publisherName>
    <publisherPlace>Oxford</publisherPlace>
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    <title language="eng">QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy</title>
    <abstract language="eng">A modern day light microscope has evolved from a tool devoted to making primarily empirical observations to what is now a sophisticated, quantitative device that is an integral part of both physical and life science research. Nowadays, microscopes are found in nearly every experimental laboratory. However, despite their prevalent use in capturing and quantifying scientific phenomena, neither a thorough understanding of the principles underlying quantitative imaging techniques nor appropriate knowledge of how to calibrate, operate and maintain microscopes can be taken for granted. This is clearly demonstrated by the well-documented and widespread difficulties that are routinely encountered in evaluating acquired data and reproducing scientific experiments. Indeed, studies have shown that more than 70% of researchers have tried and failed to repeat another scientist’s experiments, while more than half have even failed to reproduce their own experiments1. One factor behind the reproducibility crisis of experiments published in scientific journals is the frequent underreporting of imaging methods caused by a lack of awareness and/or a lack of knowledge of the applied technique2,3. Whereas quality control procedures for some methods used in biomedical research, such as genomics (e.g., DNA sequencing, RNA-seq) or cytometry, have been introduced (e.g. ENCODE4), this issue has not been tackled for optical microscopy instrumentation and images. Although many calibration standards and protocols have been published, there is a lack of awareness and agreement on common Standards and guidelines for quality assessment and reproducibility5.&#13;
In April 2020, the QUality Assessment and REProducibility for instruments and images in Light Microscopy (QUAREP-LiMi) initiative6 was formed. This initiative comprises imaging scientists from academia and industry who share a common interest in achieving a better understanding of the performance and limitations of microscopes and improved quality control (QC) in light microscopy. The ultimate goal of the QUAREP-LiMi initiative is to establish a set of common QC standards, guidelines, metadata models7,8, and tools9,10, including detailed protocols, with the ultimate aim of improving reproducible advances in scientific research.&#13;
This White Paper 1) summarizes the major obstacles identified in the field that motivated the launch of the QUAREP-LiMi initiative; 2) identifies the urgent need to address these obstacles in a grassroots manner, through a community of Stakeholders including, researchers, imaging scientists11, bioimage analysts, bioimage informatics developers, corporate partners, Funding agencies, standards organizations, scientific publishers, and observers of such; 3) outlines the current actions of the QUAREPLiMi initiative, and 4) proposes future steps that can be taken to improve the dissemination and acceptance of the proposed guidelines to manage QC.&#13;
To summarize, the principal goal of the QUAREP-LiMi initiative is to improve the overall quality and reproducibility of light microscope image data by introducing broadly accepted standard practices and accurately captured image data metrics.</abstract>
    <parentTitle language="eng">Journal of microscopy</parentTitle>
    <identifier type="doi">10.1111/jmi.13041</identifier>
    <identifier type="issn">1365-2818</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-530629</identifier>
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    <enrichment key="date_peer_review">05.08.2021</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>G. Nelson</author>
    <author>U. Boehm</author>
    <author>S. Bagley</author>
    <author>P. Bajcsy</author>
    <author>J. Bischof</author>
    <author>C. M. Brown</author>
    <author>A. Dauphin</author>
    <author>I. M. Dobbie</author>
    <author>J. E. Eriksson</author>
    <author>O. Faklaris</author>
    <author>J. Fernandez-Rodriguez</author>
    <author>A. Ferrand</author>
    <author>L, Gelman</author>
    <author>A. Gheisari</author>
    <author>H. Hartmann</author>
    <author>C. Kukat</author>
    <author>A. Laude</author>
    <author>M. Mitkovski</author>
    <author>S. Munck</author>
    <author>A. J. North</author>
    <author>T. Rasse</author>
    <author>Ute Resch-Genger</author>
    <author>L. C. Schuetz</author>
    <author>A. Seitz</author>
    <author>C. Strambio-De-Castillia</author>
    <author>J. R. Swedlow</author>
    <author>I. Alexopoulos</author>
    <author>K. Aumayr</author>
    <author>S. Avilov</author>
    <author>G.-J. Bakker</author>
    <author>R. R. Bammann</author>
    <author>A. Bassi</author>
    <author>H. Beckert</author>
    <author>S. Beer</author>
    <author>Y. Belyaev</author>
    <author>J. Bierwagen</author>
    <author>K. A. Birngruber</author>
    <author>M. Bosch</author>
    <author>J. Breitlow</author>
    <author>L. A. Cameron</author>
    <author>J. Chalfoun</author>
    <author>J. J. Chambers</author>
    <author>C.-L. Chen</author>
    <author>E. Conde-Sousa</author>
    <author>A. D. Corbett</author>
    <author>F. P. Cordelieres</author>
    <author>E. Del Nery</author>
    <author>R. Dietzel</author>
    <author>F. Eismann</author>
    <author>E. Fazeli</author>
    <author>A. Felscher</author>
    <author>H. Fried</author>
    <author>N. Gaudreault</author>
    <author>W. I. Goh</author>
    <author>T. Guilbert</author>
    <author>R. Hadleigh</author>
    <author>P. Hemmerich</author>
    <author>G. A. Holst</author>
    <author>M. S. Itano</author>
    <author>C. B. Jaffe</author>
    <author>H. K. Jambor</author>
    <author>S. C. Jarvis</author>
    <author>A. Keppler</author>
    <author>D. Kirchenbuechler</author>
    <author>M. Kirchner</author>
    <author>N. Kobayashi</author>
    <author>G. Krens</author>
    <author>S. Kunis</author>
    <author>J. Lacoste</author>
    <author>M. Marcello</author>
    <author>G. G. Martins</author>
    <author>D. J. Metcalf</author>
    <author>C. A. Mitchell</author>
    <author>J. Moore</author>
    <author>T. Mueller</author>
    <author>M. S. Nelson</author>
    <author>S. Ogg</author>
    <author>S. Onami</author>
    <author>A. L. Palmer</author>
    <author>P. Paul-Gilloteaux</author>
    <author>J. A. Pimentel</author>
    <author>L. Plantard</author>
    <author>S. Podder</author>
    <author>E. Rexhepaj</author>
    <author>A. Royon</author>
    <author>M. A. Saari</author>
    <author>D. Schapman</author>
    <author>V. Schoonderwoert</author>
    <author>B. Schroth-Diez</author>
    <author>S. Schwartz</author>
    <author>M. Shaw</author>
    <author>M. Spitaler</author>
    <author>M. T. Stoeckl</author>
    <author>D. Sudar</author>
    <author>J. Teillon</author>
    <author>S. Terjung</author>
    <author>R. Thuenauer</author>
    <author>C. D. Wilms</author>
    <author>G. D. Wright</author>
    <author>R. Nitschke</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Quality assurance</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Comparability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Standards</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reliability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Data</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference data</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Medicine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Life science</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.2 Biophotonik</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
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    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/53062/jmi.13041.pdf</file>
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  <doc>
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    <publishedYear>2021</publishedYear>
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    <language>eng</language>
    <pageFirst>1424</pageFirst>
    <pageLast>1427</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>18</volume>
    <type>article</type>
    <publisherName>Nature Publishing Group</publisherName>
    <publisherPlace>London</publisherPlace>
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    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
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    <title language="eng">QUAREP-LiMi: A community endeavor to advance quality assessment and reproducibility in light microscopy</title>
    <abstract language="eng">The community-driven initiative Quality Assessment and Reproducibility for Instruments &amp; Images in Light Microscopy (QUAREP-LiMi) wants to improve reproducibility for light microscopy image data through Quality control (QC) management of instruments and images. It aims for a common set of QC guidelines for Hardware calibration and image acquisition, management and analysis.</abstract>
    <parentTitle language="eng">Nature methods</parentTitle>
    <identifier type="doi">10.1038/s41592-021-01162-y</identifier>
    <identifier type="issn">1548-7105</identifier>
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    <enrichment key="date_peer_review">02.06.2021</enrichment>
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    <author>U. Boehm</author>
    <author>G. Nelson</author>
    <author>C. M. Brown</author>
    <author>S. Bagley</author>
    <author>P. Bajcsy</author>
    <author>J. Bischof</author>
    <author>A. Dauphin</author>
    <author>I. M. Dobbie</author>
    <author>J. E. Eriksson</author>
    <author>O. Faklaris</author>
    <author>J. Fernandez-Rodriguez</author>
    <author>A. Ferrand</author>
    <author>L. Gelman</author>
    <author>A. Gheisari</author>
    <author>H. Hartmann</author>
    <author>C. Kukat</author>
    <author>A. Laude</author>
    <author>M. Mitkovski</author>
    <author>S. Munck</author>
    <author>A. J. North</author>
    <author>T. M. Rasse</author>
    <author>Ute Resch-Genger</author>
    <author>L. C. Schuetz</author>
    <author>A. Seitz</author>
    <author>C. Strambio-De-Castillia</author>
    <author>J. R. Swedlow</author>
    <author>R. Nitschke</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Quality assurance</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Comparability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Standards</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reliability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Data</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference data</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Medicine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Life science</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
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    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
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    <publishedYear>2022</publishedYear>
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    <completedDate>--</completedDate>
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    <title language="eng">Author correction: QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy</title>
    <abstract language="eng">This is a corrigendum to the original article "QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy" that was published in the journal "Nature methods", vol. 18 (2021), pp. 1424-1427.</abstract>
    <parentTitle language="eng">Nature methods</parentTitle>
    <identifier type="issn">1548-7105</identifier>
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